Pharmacology of proton pump inhibitors [PDF]
Current Gastroenterology Reports, 2008 The gastric H,K-ATPase is the primary target for the treatment of acid-related diseases. Proton pump inhibitors (PPIs) are weak bases composed of two moieties, a substituted pyridine with a primary pK(a) of about 4.0, which allows selective accumulation in the secretory canaliculus of the parietal cell, and a benzimidazole with a second pK(a) of about ...
Jai Moo, Shin, George, Sachs
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Hypomagnesemia Induced by Long-Term Treatment with Proton-Pump Inhibitors
Gastroenterology Research and Practice, 2015 In 2006, hypomagnesemia was first described as a complication of proton-pump inhibitors. To address this issue, we systematically reviewed the literature.
Simone Janett +7 more
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Laparoscopic fundoplication compared with medical management for gastro-oesophageal reflux disease : cost effectiveness study [PDF]
, 2009 Peer reviewedPublisher ...
Bojke, Laura +4 more
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Pharmacologic Properties of Proton Pump Inhibitors [PDF]
, 2003 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90231/1/phco.23.13.74S.31929 ...
Welage, Lynda S.
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Overprescribing proton pump inhibitors [PDF]
BMJ, 2008 Proton pump inhibitors are one of the most frequently prescribed classes of drug in the world because they combine a high level of efficacy with low toxicity. In 2006, expenditure on these drugs was £425m (€595m; $872m) in England1 and £7bn globally.2 Yet studies consistently show that proton pump inhibitors are being overprescribed worldwide in both ...
Ian, Forgacs, Aathavan, Loganayagam
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Prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease : systematic review. [PDF]
, 2003 Objectives: To ascertain the prevalence of Helicobacter pylori in patients with gastro-oesophageal reflux disease and its association with the disease.
Childs, S. +3 more
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ENDOSCOPIC AND HISTOPATHOLOGIC GASTRIC CHANGES IN CHRONIC USERS OF PROTON-PUMP INHIBITORS
Arquivos de Gastroenterologia, 2015 Background Proton-pump inhibitors have been used for at least two decades. They are among the most commonly sold drugs in the world. However, some controversy remains about the indications for their use and the consequences of their prolonged use ...
Sílvia Maria Perrone CAMILO +5 more
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Type of stress ulcer prophylaxis and risk of nosocomial pneumonia in cardiac surgical patients: cohort study [PDF]
, 2014 Objective: To examine the relation between the type of stress ulcer prophylaxis administered and the risk of postoperative pneumonia in patients undergoing coronary artery bypass grafting. Design: Retrospective cohort study.
Bateman, Brian T +9 more
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Chronic cough and esomeprazole: A double-blind placebo-controlled parallel study [PDF]
, 2011 Background and objective: Gastro-oesophageal reflux has been implicated in the pathogenesis of chronic cough. Guidelines on management suggest a therapeutic trial of anti-reflux medication.
Beecher +41 more
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PLoS ONE, 2019 Stroke patients are at high risk of developing pneumonia, which is major cause of post-stroke mortality. Proton pump inhibitors and H2 receptor antagonists are anti-ulcer drugs, which may predispose to the development of pneumonia by suppression of the ...
Tae-Jin Song, Jinkwon Kim
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