Results 21 to 30 of about 143,596 (340)

Association of Histamine-2 Blockers and Proton-Pump Inhibitors With Delirium Development in Critically Ill Adults: A Retrospective Cohort Study

Critical Care Explorations, 2021
OBJECTIVES:. Histamine-2 receptor antagonists are commonly administered for stress ulcer prophylaxis in critically ill adults and may be associated with delirium development.
Ami Shiddapur, BS, Christine E. Kistler, MD, MASc, Jan Busby-Whitehead, MD, C. Adrian Austin, MD, MSCR   +3 more
doaj   +1 more source

Safety of Proton Pump Inhibitors Based on a Large, Multi-year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin.

Gastroenterology, 2019
BACKGROUND & AIMS Proton pump inhibitors (PPIs) are effective at treating acid-related disorders. These drugs are well tolerated in the short term, but long-term treatment was associated with adverse events in observational studies.
P. Moayyedi, J. Eikelboom, J. Bosch, S. Connolly, L. Dyal, O. Shestakovska, D. Leong, Sonia S Anand, S. Störk, K. Branch, Deepak L. Bhatt, P. Verhamme, M. O’Donnell, A. Maggioni, E. Lonn, L. Piegas, G. Ertl, M. Keltai, N. C. Bruns, E. Muehlhofer, G. Dagenais, Jae‐Hyung Kim, M. Hori, P. Steg, R. Hart, R. Diaz, M. Alings, P. Widimsky, Á. Avezum, J. Probstfield, Jun Zhu, Yan Liang, P. López-Jaramillo, A. Kakkar, A. Parkhomenko, L. Rydén, N. Pogosova, A. Dans, F. Lanas, P. Commerford, C. Torp-Pedersen, T. Guzik, D. Vinereanu, A. Tonkin, B. Lewis, C. Félix, K. Yusoff, K. Metsarinne, K. Fox, S. Yusuf   +49 more
semanticscholar   +1 more source

Hypomagnesemia Induced by Long-Term Treatment with Proton-Pump Inhibitors

Gastroenterology Research and Practice, 2015
In 2006, hypomagnesemia was first described as a complication of proton-pump inhibitors. To address this issue, we systematically reviewed the literature.
Simone Janett, Pietro Camozzi, Gabriëlla G. A. M. Peeters, Sebastiano A. G. Lava, Giacomo D. Simonetti, Barbara Goeggel Simonetti, Mario G. Bianchetti, Gregorio P. Milani   +7 more
doaj   +1 more source

Proton Pump Inhibitors [PDF]

Gut, 2000
Proton Pump Inhibitors . Edited by Olbe L. (Pp 264; illustrated; sFr198.00.) Switzerland: Birkhauser Verlag. 1999. ISBN 3 76435 897 1. The history of the development of drugs to treat the so-called acid related diseases makes a fascinating story, and the publication of this book addresses a significant chapter in that story.
openaire   +3 more sources

Proton pump inhibitors affect the gut microbiome

Gut, 2015
Background and aims Proton pump inhibitors (PPIs) are among the top 10 most widely used drugs in the world. PPI use has been associated with an increased risk of enteric infections, most notably Clostridium difficile.
F. Imhann, M. Bonder, A. Vich Vila, Jingyuan Fu, Z. Mujagic, L. Vork, E. Tigchelaar, S. Jankipersadsing, M. Cénit, H. Harmsen, G. Dijkstra, L. Franke, R. Xavier, D. Jonkers, C. Wijmenga, R. Weersma, A. Zhernakova   +16 more
semanticscholar   +1 more source

ENDOSCOPIC AND HISTOPATHOLOGIC GASTRIC CHANGES IN CHRONIC USERS OF PROTON-PUMP INHIBITORS

Arquivos de Gastroenterologia, 2015
Background Proton-pump inhibitors have been used for at least two decades. They are among the most commonly sold drugs in the world. However, some controversy remains about the indications for their use and the consequences of their prolonged use ...
Sílvia Maria Perrone CAMILO, Élia Cláudia de Souza ALMEIDA, Benito André Silveira MIRANZI, Juliano Carvalho SILVA, Rosemary Simões NOMELINI, Renata Margarida ETCHEBEHERE   +5 more
doaj   +1 more source

Proton pump inhibitors and dysbiosis: Current knowledge and aspects to be clarified

World Journal of Gastroenterology, 2019
Proton pump inhibitors (PPIs) are common medications within the practice of gastroenterology. These drugs, which act through the irreversible inhibition of the hydrogen/potassium pump (H+/K+-ATPase pump) in the gastric parietal cells, are used in the ...
G. Bruno, P. Zaccari, G. Rocco, G. Scalese, C. Panetta, B. Porowska, S. Pontone, C. Severi   +7 more
semanticscholar   +1 more source

Adverse Effects of Proton Pump Inhibitors—Evidence and Plausibility

International Journal of Molecular Sciences, 2019
Proton pump inhibitors (PPIs) have been increasingly used over the last decades and there are concerns about overuse and the numerous reported side-effects.
R. Fossmark, T. C. Martinsen, H. Waldum
semanticscholar   +1 more source

Proton Pump Inhibitors and Fracture Risk: A Review of Current Evidence and Mechanisms Involved

International Journal of Environmental Research and Public Health, 2019
The number of patients with gastroesophageal problems taking proton pump inhibitors (PPIs) is increasing. Several studies suggested a possible association between PPIs and fracture risk, especially hip fractures, but the relationship remains contentious.
B. K. S. Thong, S. Ima-Nirwana, K. Chin
semanticscholar   +1 more source

Proton pump inhibitors act with unprecedented potencies as inhibitors of the acetylcholine biosynthesizing enzyme—A plausible missing link for their association with incidence of dementia

Alzheimer's & Dementia, 2020
Several pharmacoepidemiological studies indicate that proton pump inhibitors (PPIs) significantly increase the risk of dementia. Yet, the underlying mechanism is not known.
Rajnish Kumar, Amit Kumar, A. Nordberg, B. Långström, T. Darreh-Shori   +4 more
semanticscholar   +1 more source