Results 31 to 40 of about 139,988 (355)

Proton pump inhibitors act with unprecedented potencies as inhibitors of the acetylcholine biosynthesizing enzyme—A plausible missing link for their association with incidence of dementia

Alzheimer's & Dementia, 2020
Several pharmacoepidemiological studies indicate that proton pump inhibitors (PPIs) significantly increase the risk of dementia. Yet, the underlying mechanism is not known.
Rajnish Kumar, Amit Kumar, A. Nordberg, B. Långström, T. Darreh-Shori   +4 more
semanticscholar   +1 more source

Proton pump inhibitors alter the composition of the gut microbiota

Gut, 2015
Objective Proton pump inhibitors (PPIs) are drugs used to suppress gastric acid production and treat GI disorders such as peptic ulcers and gastro-oesophageal reflux.
M. Jackson, Julia Goodrich, Maria-Emanuela Maxan, D. Freedberg, J. Abrams, Angela C. Poole, Jessica L. Sutter, Daphne K. Welter, R. Ley, J. Bell, T. Spector, C. Steves   +11 more
semanticscholar   +1 more source

Risk of post-stroke pneumonia with proton pump inhibitors, H2 receptor antagonists and mucoprotective agents: A retrospective nationwide cohort study.

PLoS ONE, 2019
Stroke patients are at high risk of developing pneumonia, which is major cause of post-stroke mortality. Proton pump inhibitors and H2 receptor antagonists are anti-ulcer drugs, which may predispose to the development of pneumonia by suppression of the ...
Tae-Jin Song, Jinkwon Kim
doaj   +1 more source

The impact of drug-drug interactions between proton pump inhibitors and metformin: A systematic review of clinical evidence [PDF]

Pharmacia
Metformin, a substrate of the organic cation transporters, is commonly co-prescribed with proton pump inhibitors, which inhibits these transporters. However, the clinical significance of this potential drug-drug interaction remains unclear.
Ria Andani Antong, Ikhwan Yuda Kusuma, Marianti A. Manggau, Muh Akbar Bahar   +3 more
doaj   +3 more sources

Iron deficiency anemia from iron malabsorption caused by proton pump inhibitors

eJHaem, 2020
Background Iron deficiency anemia without evidence for blood loss can present a diagnostic challenge. Proton pump inhibitors have been associated with iron deficiency anemia for many years, yet the relationship between the two until recently was not ...
Michael Boxer
doaj   +1 more source

Proton pump inhibitors: from CYP2C19 pharmacogenetics to precision medicine

Expert Opinion on Drug Metabolism & Toxicology, 2018
Introduction: Proton Pump inhibitors (PPIs) are commonly used for a variety of acid related disorders. Despite the overall effectiveness and safety profile of PPIs, some patients do not respond adequately or develop treatment related adverse events. This
Nihal El Rouby, J. Lima, Julie A. Johnson   +2 more
semanticscholar   +1 more source

The choice of proton pump inhibitor from the standpoint of efficacy and safety in a particular patient

Лечащий Врач, 2021
Proton pump inhibitors are a diverse class of drugs with unique acid suppression properties. The aim of the work was to present the therapeutic benefits of rabeprazole and pantoprazole in clinical practice.
E. A. Lyalukova, Yu. V. Tereschenko, E. N. Chernysheva, A. V. Lyalukov   +3 more
doaj   +1 more source

No proton pump inhibitors? [PDF]

BMJ, 2007
Hickson et al have tried to introduce true scientific method in an area chiefly governed by sales tactics and mass advertising, but it is good to see their admission regarding …
openaire   +2 more sources

25 Years of Proton Pump Inhibitors: A Comprehensive Review

Gut and Liver, 2016
Proton pump inhibitors (PPIs) were clinically introduced more than 25 years ago and have since proven to be invaluable, safe, and effective agents for the management of a variety of acid-related disorders.
Daniel S Strand, Daejin Kim, D. Peura
semanticscholar   +1 more source

Systematic review with meta‐analysis: the risks of proton pump inhibitors during pregnancy

Alimentary Pharmacology and Therapeutics, 2020
There have been safety concerns considering long‐term proton pump inhibitor (PPI) use, also during pregnancy.
C. Li, A. Zhernakova, L. Engstrand, C. Wijmenga, N. Brusselaers   +4 more
semanticscholar   +1 more source