Results 71 to 80 of about 1,399,448 (251)
Advanced Science, EarlyView.LDHA‐driven lactate production in mesenchymal glioma stem cells promotes p300‐dependent H3K18 lactylation, activates USP30 transcription, and stabilizes MBOAT2 to remodel phosphatidylethanolamines toward ferroptosis‐resistant PE‐MUFA species. Disrupting this metabolic–epigenetic–lipid circuit enhances ferroptosis and sensitizes glioblastoma to ...
Zong Miao +13 more
wiley +1 more source
, 2018 Kok Ann Gwee,1 Vernadine Goh,2 Graca Lima,3 Sajita Setia4 1Stomach, Liver, and Bowel Centre, Gleneagles Hospital, 2Department of Pharmacy, National University of Singapore, Singapore; 3Global Medical Affairs, Asia-Pacific Region, Pfizer, Hong Kong ...
Lima G, Goh V, Gwee KA, Setia S
core
Pharmacogenetics of proton pump inhibitors
Медицинский совет, 2015 Proton pump inhibitors (PPI) are currently the most effective class of antisecretory drugs widely used in the treatment of non-ulcer dyspepsia, reflux esophagitis and GERD, peptic ulcer disease and H. pilory infection, as well as NSAID-associated gastric
M. V. Leonova
doaj +1 more source
Deprescribing proton pump inhibitors in the older population [PDF]
, 2022 Long-term use of proton pump inhibitors (PPIs) in the older population can cause adverse effects including hypomagnesaemia, pneumonia and fractures. Hospitalisation presents an opportunity for assessing PPI appropriateness, and dose reduction or drug
50th European Society of Clinical Pharmacy (ESCP) Symposium +3 more
core
Advanced Science, EarlyView.A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li +9 more
wiley +1 more source
Journal of the Pakistan Medical AssociationObjective: To evaluate serum prolactin and macroprolactin levels in patients on long-term proton pump inhibitors therapy. Method: The cross-sectional study was conducted from January 2018 to November 2019 after approval from the ethics review ...
Muhammad Ashfaq +3 more
doaj +1 more source
Advanced Science, EarlyView.An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang +8 more
wiley +1 more source
POTENTIAL HARMS OF THE USE OF PROTON PUMP INHIBITORS: DEBATABLE PROBLEMS [PDF]
, 2018 The paper discusses data on the high frequency of non-indicated use of proton pump inhibitors and on the manifestations of potential harms of their ...
O. R. Bobkova, Yu. V. Muravyev
core +1 more source
OsCPK12‐OsATPD1 Module Regulates Photosynthetic Acclimation to Light Stress in Rice
Advanced Science, EarlyView.OsCPK12 interacts and phosphorylates OsAtpD1 at Ser8 in its transit peptide. This phosphorylation promote its chloroplast translocation, thereby maintaining ATP synthase activity and proton gradient (ΔpH) homeostasis and regulating photosynthetic acclimation, photoprotection, and repair under light stress.
Beifang Wang +17 more
wiley +1 more source
RENAL SAFETY OF PROTON PUMP INHIBITORS
Архивъ внутренней медицины, 2017 Proton pump inhibitors are a widely used in clinical practice, and are taken by millions of patients around the world for a long time. While proton pump inhibitors are well-tolerated class of drugs, the number of publications has been raised about ...
A. I. Dyadyk, T. E. Kugler
doaj +1 more source