Results 61 to 70 of about 11,003 (167)

Biomarkers of safety and immune protection for genetically modified live attenuated Leishmania vaccines against visceral leishmaniasis-Discovery and implications

Frontiers in Immunology, 2014
Despite intense efforts there is no safe and efficacious vaccine against visceral leishmaniasis, which is fatal and endemic in many tropical countries. A major shortcoming in the vaccine development against blood borne parasitic agents such as Leishmania
Sreenivas eGannavaram, Ranadhir eDey, Kumar eAvishek, Angamuthu eSelvapandiyan, Poonam eSalotra, Hira eNakhasi   +5 more
doaj   +1 more source

Simulated Microgravity Causes Faster Replication During Acute Infection of ME49‐Toxoplasma Gondii and Alterations in Host Cells

FASEB BioAdvances, Volume 8, Issue 4, April 2026.
Simulated microgravity (SMG) alters the growth and morphology of host cells and induces parasite replication during acute T. gondii infection. In this study, we examined host cells and Type II T. gondii using a 3D clinostat. Increased number of host cells and multicellular spheroids observed in Vero cells and HFF.
Musfika Tasnim Shirin, Takafumi Yamada, Iqra Zafar, Daisuke Kondoh, Hiroki Bochimoto, Hironori Bando, Oluyomi Stephen Adeyemi, Yasuhiro Fukuda, Kentaro Kato   +8 more
wiley   +1 more source

A Self-Assembling Pfs230D1-Ferritin Nanoparticle Vaccine Has Potent and Durable Malaria Transmission-Reducing Activity

Vaccines
Malaria is caused by eukaryotic protozoan parasites of the genus Plasmodium. There are 249 million new cases and 608,000 deaths annually, and new interventions are desperately needed.
Nichole D. Salinas, Rui Ma, Holly McAleese, Tarik Ouahes, Carole A. Long, Kazutoyo Miura, Lynn E. Lambert, Niraj H. Tolia   +7 more
doaj   +1 more source

Bacterial Extracellular Vesicles in Biomedical Research and Clinical Translation

Microbial Biotechnology, Volume 19, Issue 4, April 2026.
Bacterial membrane vesicle biomedical applications. ABSTRACT Bacterial Extracellular Vesicles (bEVs) are lipid (single‐ or double‐bilayer) nanostructures secreted by virtually all bacteria that play fundamental roles in intercellular communication and have emerged as powerful, multifunctional tools in biomedicine. Their intrinsic ability to encapsulate
Alejandro Arce‐Rodríguez, Javier De la Peña Noya, José Manuel Borrero‐de Acuña   +2 more
wiley   +1 more source

Babesia bovis Enolase Is Expressed in Intracellular Merozoites and Contains B-Cell Epitopes That Induce Neutralizing Antibodies In Vitro

Vaccines
Background: Bovine babesiosis, caused by the tick-borne apicomplexan parasite Babesia spp., is an economically significant disease that threatens the cattle industry worldwide.
Alma Cárdenas-Flores, Minerva Camacho-Nuez, Massaro W. Ueti, Mario Hidalgo-Ruiz, Angelina Rodríguez-Torres, Diego Josimar Hernández-Silva, José Guadalupe Gómez-Soto, Masahito Asada, Shin-ichiro Kawazu, Alma R. Tamayo-Sosa, Rocío Alejandra Ruiz-Manzano, Juan Mosqueda   +11 more
doaj   +1 more source

Glycosomal Phosphoenolpyruvate Carboxykinase CRISPR/Cas9‐Deletion and Its Role in Trypanosoma cruzi Metacyclogenesis and Infectivity in Mammalian Host

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
Effects of PEPCK deficiency in Trypanosoma cruzi bioenergetics and life stages. ABSTRACT Trypanosoma cruzi, the causative agent of Chagas disease, possesses glycosomes—unique organelles that house key metabolic enzymes, several of which are promising therapeutic targets.
Carolina S. D. Vieira, Wei Wang, Fernando Sanchez‐Valdez, Jihyun Lim, Brooke E. White, Camilla G. S. Souza, Rick L. Tarleton, Marcia C. Paes, Natalia P. A. Nogueira   +8 more
wiley   +1 more source

Blockade of CTLA-4 promotes the development of effector CD8+ T lymphocytes and the therapeutic effect of vaccination with an attenuated protozoan expressing NY-ESO-1

Cancer Immunology, Immunotherapy, 2014
The development of cancer immunotherapy has long been a challenge. Here, we report that prophylactic vaccination with a highly attenuated Trypanosoma cruzi strain expressing NY-ESO-1 (CL-14-NY-ESO-1) induces both effector memory and effector CD8(+) T lymphocytes that efficiently prevent tumor development.
Dos Santos, L, Galvão-Filho, B, de Faria, P, Junqueira, C, Dutra, MS, Teixeira, S, Rodrigues, M, Ritter, G, Bannard, O, Fearon, D, Antonelli, L, Gazzinelli, RT   +11 more
openaire   +2 more sources

Synthetic biology for combating leishmaniasis

Frontiers in Microbiology
Leishmaniasis is a neglected tropical disease caused by protozoan parasites of the Leishmania genus. Despite the efforts to control and treat the disease, it still remains a major public health problem in many countries.
Shweta Khandibharad, Shailza Singh
doaj   +1 more source

Emerging role of γδ T cells in vaccine‐mediated protection from infectious diseases

Clinical & Translational Immunology, 2019
γδ T cells are fascinating cells that bridge the innate and adaptive immune systems. They have long been known to proliferate rapidly following infection; however, the identity of the specific γδ T cell subsets proliferating and the role of this ...
Kathleen W Dantzler, Lauren de laParte, Prasanna Jagannathan   +2 more
doaj   +1 more source

The Combined Deficiency of Immunoproteasome Subunits Affects Both the Magnitude and Quality of Pathogen- and Genetic Vaccination-Induced CD8+ T Cell Responses to the Human Protozoan Parasite Trypanosoma cruzi

PLOS Pathogens, 2016
The β1i, β2i and β5i immunoproteasome subunits have an important role in defining the repertoire of MHC class I-restricted epitopes. However, the impact of combined deficiency of the three immunoproteasome subunits in the development of protective immunity to intracellular pathogens has not been investigated. Here, we demonstrate that immunoproteasomes
Ersching, Jonatan, Vasconcelos, Jose Ronnie, Ferreira, Camila P., Caetano, Braulia C., Machado, Alexandre Vieira, Bruna-Romero, Oscar, Baron, Monique A., Ferreira, Ludmila R.P., Cunha-Neto, Edecio, Rock, Kenneth L., Gazzinelli, Ricardo T, Rodrigues, Mauricio Martins   +11 more
openaire   +5 more sources