Results 101 to 110 of about 16,784 (210)
Virological and Immunological Aspects of AIDS Pathogenesis
Canadian Journal of Infectious Diseases, 1994 The most common and serious problem associated with long term antiretroviral therapy is waning efficacy over time. To date. a number of studies has suggested an association between drug resistance and clinical deterioration. However.
Brian Conway, Francisco J Diaz-Mitoma
doaj +1 more source
From Genomic and Epigenomic Maps to Medicines in Adult T‐Cell Leukemia/Lymphoma
Cancer Science, Volume 117, Issue 2, Page 289-296, February 2026.ABSTRACT Adult T‐cell leukemia/lymphoma (ATL) is an aggressive and refractory hematologic malignancy that is caused by human T‐cell leukemia virus type‐1 (HTLV‐1) retrovirus. ATL results from a combination of viral latency and the accumulation of abnormalities throughout the genome, epigenome, transcriptome, and signaling pathways.
Kako Suzuki, Makoto Yamagishi
wiley +1 more source
Association of Sicca Syndrome with Proviral Load and Proinflammatory Cytokines in HTLV-1 Infection
Journal of Immunology Research, 2016 TheSjögrensyndrome has been diagnosed in patients with HTLV-1 associated myelopathy and dry mouth and dry eyes are documented in HTLV-1 carriers. However the diagnosis ofSjögrensyndrome in these subjects has been contested. In this cross-sectional study, we evaluated the role of immunological factors and proviral load, in sicca syndrome associated with
Clara Mônica Lima +7 more
openaire +3 more sources
HIV Medicine, Volume 27, Issue 2, Page 217-225, February 2026.Abstract Objective Evaluate factors associated with discontinuation of long‐acting injectable (LAI) cabotegravir/rilpivirine (CAB/RPV) and describe virologic outcomes in those that returned to oral antiretroviral therapy (ART). Methods This is a retrospective cohort study at a single‐centre primary care HIV clinic.
Tali Faggiano +6 more
wiley +1 more source
Tissue memory CD4+ T cells expressing IL-7 receptor-alpha (CD127) preferentially support latent HIV-1 infection. [PDF]
, 2020 The primary reservoir for HIV is within memory CD4+ T cells residing within tissues, yet the features that make some of these cells more susceptible than others to infection by HIV is not well understood.
Cavrois, Marielle +16 more
core +1 more source
HLA, Volume 107, Issue 2, February 2026.ABSTRACT Bovine leukaemia virus (BLV) infects cattle, integrates into the host genome as a provirus, and induces a persistent infection that remains asymptomatic but can cause leukaemia/lymphoma. Most BLV‐infected cell clones are created by massive depletion, and a few of these infected cell clones expand through the mitotic cycle, leading to the onset
Noriko Fukushi +10 more
wiley +1 more source
Human APOBEC3G-mediated hypermutation is associated with antiretroviral therapy failure in HIV-1 subtype C-infected individuals [PDF]
, 2013 Introduction: Human APOBEC3G/F (hA3G/F) restricts retroviral replication through G-to-A hypermutations, which can generate drug-resistant progenies in vitro. The clinical relevance is still inconclusive.
Akhil C Banerjea +37 more
core +1 more source
The Journal of Pathology: Clinical Research, Volume 12, Issue 1, January 2026.Abstract Adult T‐cell leukemia/lymphoma (ATLL) is a distinct type of peripheral T‐cell lymphoma (PTCL) driven by human T‐lymphotropic virus type I (HTLV‐1)–infected T cells, but diagnosis can be confounded by histological overlap with non‐ATLL PTCL. While molecular testing is the diagnostic gold standard in endemic areas, HTLV‐1/2 serology is often ...
Chang‐Tsu Yuan +10 more
wiley +1 more source
Retrovirology, 2006 Background No therapies have been proven to persistently improve the outcome of HTLV-I-associated myelopathy. Clinical benefit has been reported with zidovudine and with lamivudine in observational studies.
Rudge Peter +12 more
doaj +1 more source
Host factors and early treatments to restrict paediatric HIV infection and early disease progression [PDF]
, 2015 open6noA body of evidence indicates that a threshold level of the virus is required to establish systemic and persistent HIV infection in the host and that this level depends on virus-host interactions.
De Rossi, Anita +5 more
core +1 more source