Results 61 to 70 of about 10,657 (203)

Characterizing the emergence and persistence of drug resistant mutations in HIV-1 subtype C infections using 454 ultra deep pyrosequencing. [PDF]

, 2013
BACKGROUND: The role of HIV-1 RNA in the emergence of resistance to antiretroviral therapies (ARTs) is well documented while less is known about the role of historical viruses stored in the proviral DNA. The primary focus of this work was to characterize
Grace P McCormack, Crampin, Amelia C., Bansode, Vijay, McCormack, Grace P., Glynn, Judith R., Neil French, Ram K Shrestha, Travers, Simon A, Simon A Travers, French, Neil, Glynn, Judith R, Crampin, Amelia C, Vijay Bansode, Judith R Glynn, Vijay Bansode, Amelia C Crampin, McCormack, Grace P, Travers, Simon A., Shrestha, Ram K., Ngwira, Bagrey, Shrestha, Ram K, Bagrey Ngwira   +21 more
core   +1 more source

Statistical analysis of proviral load in infected rabbits.

, 2023
Whole blood was collected and rPBMCs were isolated from rabbits infected with WT, M3, ΔHbz, M3.ΔHbz, or SAm viruses at Weeks 2, 4, 8, and 12 post-infection. Genomic DNA was extracted for detection of HTLV-1 proviral load by qPCR.
Victoria Maksimova (16384820), Tasha Wilkie (16384823), Susan Smith (377252), Patrick L. Green (14676264), Cameron Phelps (16384826), Corrine Melvin (16384829), Amanda R. Panfil (14676267), Stefan Niewiesk (234126), Lianbo Yu (144585)   +8 more
core   +1 more source

A viral clonality evenness score to predict progression to adult T-cell leukaemia in asymptomatic carriers of human T-lymphotropic virus type 1 in Japan: a retrospective longitudinal cohort study

The Lancet Microbe
Summary: Background: Adult T-cell leukaemia/lymphoma (ATL) is a highly aggressive T-cell malignancy that occurs in approximately 2–7% of individuals with human T-lymphotropic virus type 1 (HTLV-1), after decades of asymptomatic infection. To address the
Snehal Dilip Karpe, PhD, Maria Artesi, PhD, Jérôme Wayet, MSc, Keith Durkin, PhD, Vincent Hahaut, PhD, ProfMD Kaoru Uchimaru, PhD, Junya Makiyama, MD, ProfMD Masako Iwanaga, MD, Atae Utsunomiya, MD, P Martijn Kolijn, PhD, ProfPhD Anton W Langerak, PhD, ProfPhD Arsène Burny, PhD, Ambroise Marçais, MD, ProfMD Olivier Hermine, MD, ProfMD Toshiki Watanabe, MD, ProfPhD Michel Georges, MD, Anne Van den Broeke, PhD   +16 more
doaj   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Detection of HTLV-1 proviral DNA in cell-free DNA: Potential for non-invasive monitoring of Adult T cell leukaemia/lymphoma using liquid biopsy?

Frontiers in Immunology, 2023
IntroductionFragmented genomic DNA is constitutively released from dying cells into interstitial fluid in healthy tissue. In cancer, this so-called ‘cell-free’ DNA (cfDNA) released from dying malignant cells encodes cancer-associated mutations.
Thomas Joris, Thomas Joris, Jana Haddow, Graham P. Taylor, Graham P. Taylor, Lucy B. M. Cook, Lucy B. M. Cook, Lucy B. M. Cook, Lucy B. M. Cook, Aileen G. Rowan   +9 more
doaj   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

HTLV-I proviral load in Argentinean subjects with indeterminate western blot patterns [PDF]

Retrovirology, 2011
Metodología Se estudiaron un total de 87 muestras WB indeterminadas (HTLV blot 2.4 assayGenelabs Diagnostics-) durante un periodo de 10 años derivadas del Banco de Sangre del Hospital Garrahan (n=83) y de la Unidad de Virología del Hospital Muniz (n=4). Las secuencias provirales de HTLV-I y –II Tax y pol se amplificaron mediante ensayos de PCR anidados
Andrea Mangano, Natalia Altamirano, Mirta Remesar, María Belén Bouzas, Paula Aulicino, Inés Zapiola, Ana del Pozo‐Rodríguez, Luisa Sen   +7 more
openaire   +2 more sources

Correlation between bta-miRNA sequencing reads and BLV proviral load (PVL) and AS1 mRNA expression.

, 2021
Correlation between bta-miRNA sequencing reads and BLV proviral load (PVL) and AS1 mRNA expression.
Sota Kobayashi (513373), Shinji Yamada (1488268), Chihiro Ochiai (11419577), Leng Dongze (11419589), Kenji Murakami (1903816), Syuji Yoneyama (11419586), Hirokazu Hikono (777043), Toshihiro Ichijo (5852330), Sonoko Miyauchi (11419580), Yuta Kudo (1816669), Keisuke Tomita (6499151), Yusuke Chiba (4526509), Kazuya Nagai (11419595), To-ichi Hirata (11419592), Yuta Naruke (11419583)   +14 more
core   +1 more source

Brain viral reservoir seeding and neurological metabolic dysregulation in early‐life immunodeficiency virus infection

Brain Pathology, EarlyView.
Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma, Robert Blair, Yao‐Zhong Liu, Xiaolei Wang, Eunice Vincent, Christopher Yu, Lara A. Doyle‐Meyers, Cissy Zhang, Ahmad Saied, Anne Le, Ronald S. Veazey, Qigui Yu, Huanbin Xu   +12 more
wiley   +1 more source

HIV‐1 viral load and reservoir size remain stable following SARS‐CoV‐2 mRNA vaccination in people with HIV

HIV Medicine, EarlyView.
Abstract Background The potent immunogenicity of mRNA vaccination raised concerns about its impact on HIV‐1 viral load (VL) and reservoir size in people with HIV, which could drive vaccine hesitancy. As part of a prospective clinical trial, we investigated whether SARS‐CoV‐2 mRNA vaccination induced changes in VL and reservoir size after a 1‐year three‐
Oscar Kieri, Bianca B Jütte, Jan Vesterbacka, Soo Aleman, Hans‐Gustaf Ljunggren, Marcus Buggert, J Peter Svensson, Anders Sönnerborg, Piotr Nowak   +8 more
wiley   +1 more source