Results 71 to 80 of about 3,180,845 (188)

Long‐term follow‐up study on SIV intestinal proviral load in rhesus macaques

Journal of Medical Primatology, 2000
After experimental infection with simian immunodeficiency virus (SIV), intestinal endoscopy proved to be an easily tolerated, minimal invasive procedure to obtain biopsies from the gastrointestinal tract of rhesus macaques during all stages of disease.
Didier, Andrea, Petry, Harald, Stahl-Hennig, Christiane, Schäfer, Marco, Zeitz, Ulrich, Schneider, Thomas, Boga, José Antonio, Mätz-Rensing, Kerstin, Herrmann, Katrin, Kaup, Franz-Josef   +9 more
openaire   +3 more sources

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

A viral clonality evenness score to predict progression to adult T-cell leukaemia in asymptomatic carriers of human T-lymphotropic virus type 1 in Japan: a retrospective longitudinal cohort study

The Lancet Microbe
Summary: Background: Adult T-cell leukaemia/lymphoma (ATL) is a highly aggressive T-cell malignancy that occurs in approximately 2–7% of individuals with human T-lymphotropic virus type 1 (HTLV-1), after decades of asymptomatic infection. To address the
Snehal Dilip Karpe, PhD, Maria Artesi, PhD, Jérôme Wayet, MSc, Keith Durkin, PhD, Vincent Hahaut, PhD, ProfMD Kaoru Uchimaru, PhD, Junya Makiyama, MD, ProfMD Masako Iwanaga, MD, Atae Utsunomiya, MD, P Martijn Kolijn, PhD, ProfPhD Anton W Langerak, PhD, ProfPhD Arsène Burny, PhD, Ambroise Marçais, MD, ProfMD Olivier Hermine, MD, ProfMD Toshiki Watanabe, MD, ProfPhD Michel Georges, MD, Anne Van den Broeke, PhD   +16 more
doaj   +1 more source

A multiplex interactome of Ebola virus proteins reveals TM9SF2 as a cell‐surface attachment factor that promotes viral entry

iMetaOmics, EarlyView.
This study generates a comprehensive Ebola virus (EBOV)‐human protein–protein interactome, comprising 1728 core high‐confidence interactions. Further interactome analysis revealed the potential association of EBOV glycoprotein (GP) with the host factor TM9SF2. Subsequent mechanistic investigations confirmed that TM9SF2 functions as an attachment factor
Limin Shang, Shouwen Du, Yuchen Liu, Letian Li, Xi Wu, Yanzhi Yuan, Chaozhi Jin, Qingkun Mi, Yuhang Wang, Xiaoshuang Shi, Jiamin Wang, Guoqing Zhang, Yidan Ma, Weijin Huang, Jigang Wang, Jian Wang, Chang Li   +16 more
wiley   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Detection of HTLV-1 proviral DNA in cell-free DNA: Potential for non-invasive monitoring of Adult T cell leukaemia/lymphoma using liquid biopsy?

Frontiers in Immunology, 2023
IntroductionFragmented genomic DNA is constitutively released from dying cells into interstitial fluid in healthy tissue. In cancer, this so-called ‘cell-free’ DNA (cfDNA) released from dying malignant cells encodes cancer-associated mutations.
Thomas Joris, Thomas Joris, Jana Haddow, Graham P. Taylor, Graham P. Taylor, Lucy B. M. Cook, Lucy B. M. Cook, Lucy B. M. Cook, Lucy B. M. Cook, Aileen G. Rowan   +9 more
doaj   +1 more source

HTLV-I proviral load in Argentinean subjects with indeterminate western blot patterns [PDF]

Retrovirology, 2011
Metodología Se estudiaron un total de 87 muestras WB indeterminadas (HTLV blot 2.4 assayGenelabs Diagnostics-) durante un periodo de 10 años derivadas del Banco de Sangre del Hospital Garrahan (n=83) y de la Unidad de Virología del Hospital Muniz (n=4). Las secuencias provirales de HTLV-I y –II Tax y pol se amplificaron mediante ensayos de PCR anidados
Andrea Mangano, Natalia Altamirano, Mirta Remesar, María Belén Bouzas, Paula Aulicino, Inés Zapiola, Ana del Pozo‐Rodríguez, Luisa Sen   +7 more
openaire   +2 more sources

Integrating novel therapeutic strategies in myeloproliferative neoplasms: Driving disease‐directed progress

British Journal of Haematology, EarlyView.
Summary Over the past decade, there has been a substantial increase in the diversity and number of therapeutic options for myeloproliferative neoplasms (MPNs). While many remain within the clinical trial arena, the clinician and patient community have seen more approvals reaching the clinic and a rethink on how best we should be approaching these ...
Trung Q. Ngo, Maria Georgiou, Donal P. McLornan, Claire N. Harrison   +3 more
wiley   +1 more source

Brain viral reservoir seeding and neurological metabolic dysregulation in early‐life immunodeficiency virus infection

Brain Pathology, EarlyView.
Brain viral reservoirs were undetectable in neonatal SIV during the first 3 days post infection; antiretroviral therapy (ART) at 3 dpi prevented brain reservoir seeding and normalized metabolic function, highlighting the necessity of very early treatment to protect the developing CNS.
Li Ma, Robert Blair, Yao‐Zhong Liu, Xiaolei Wang, Eunice Vincent, Christopher Yu, Lara A. Doyle‐Meyers, Cissy Zhang, Ahmad Saied, Anne Le, Ronald S. Veazey, Qigui Yu, Huanbin Xu   +12 more
wiley   +1 more source

Host genetic factors associated to proviral load in Peruvian HTLV-1 infected [PDF]

Retrovirology, 2011
Patients with HTLV-1 associated myelopathy (HAM/TSP) tend to present higher HTLV-1 proviral load (PVL) than asymptomatic carriers (AC). PVL remains the only marker consistently associated with HAM/TSP across several populations. We report a candidate gene study to identify associations between host genetic markers and PVL.
Clark Daniel, Tipismana Martin, González Elsa, Verdonck Kristien, Huyghe Jeroen R, López1 Giovanni, Talledo Michael, Vanham Guido, Gotuzzo Eduardo, Van Camp Guy, Van Laer Lut   +10 more
openaire   +2 more sources