Prospero-related homeobox protein 1 (Prox1) enhances myelin sheath regeneration in injured sciatic nerve [PDF]
IBRO Neuroscience ReportsBackground: Peripheral nerve injury (PNI), such as sciatic nerve injury (SNI), often results in poor functional recovery due to myelin damage, which critically impairs nerve regeneration.
Linlin Jie +6 more
doaj +3 more sources
PROX1 is an early driver of lineage plasticity in prostate cancer [PDF]
The Journal of Clinical InvestigationLineage plasticity is recognized as a critical determinant of lethality and resistance to AR pathway inhibitors in prostate cancer. Lineage plasticity is a continuum, ranging from AR activity-low tumors, AR-null tumors that do not express a ...
Zhi Duan +45 more
doaj +3 more sources
Prox1 and FOXC2 act as regulators of lymphangiogenesis and angiogenesis in oral squamous cell carcinoma. [PDF]
PLoS ONE, 2014 Prospero homeobox 1 (Prox1) and forkhead box (FOX) C2 regulate angiogenesis and/or lymphangiogenesis. However, the detailed role and function of Prox1 and FOXC2 in cancer remains controversial.
Tomonori Sasahira +7 more
doaj +3 more sources
Prox1 Is a Marker for AII Amacrine Cells in the Mouse Retina [PDF]
Frontiers in Neuroanatomy, 2017 The transcription factor Prox1 is expressed in multiple cells in the retina during eye development. This study has focused on neuronal Prox1 expression in the inner nuclear layer (INL) of the adult mouse retina.
Luis Pérez de Sevilla Müller +6 more
doaj +2 more sources
Prox1 Suppresses the Proliferation of Breast Cancer Cells via Direct Inhibition of c-Myc Gene Expression [PDF]
Cells, 2023 Breast cancer is one of the most lethal malignancies in women worldwide and is characterized by rapid growth and low survival rates, despite advances in tumor biology and therapies.
Artemis Michail +4 more
doaj +2 more sources
High PROX1 expression in gastric cancer predicts better survival. [PDF]
PLoS ONE, 2017 PROX1 is a transcription factor involved in the development of various organs. It has also an important function in colorectal cancer progression. The aim of this study was to investigate the prognostic role of PROX1 expression in gastric cancer.We ...
Alli Laitinen +5 more
doaj +3 more sources
PROX1 Expression in Resected Non-Small Cell Lung Cancer: Immunohistochemical Profile and Clinicopathological Correlates [PDF]
Medical SciencesBackground/Objectives: PROX1 (prospero homeobox 1) is a transcription factor involved in lymphangiogenesis and cellular differentiation. Its role in cancer biology appears to be highly context-dependent, with it exhibiting both tumor-promoting and ...
Evangelia Ntikoudi +8 more
doaj +2 more sources
Vegfc Regulates Bipotential Precursor Division and Prox1 Expression to Promote Lymphatic Identity in Zebrafish [PDF]
Cell Reports, 2015 Lymphatic vessels arise chiefly from preexisting embryonic veins. Genetic regulators of lymphatic fate are known, but how dynamic cellular changes contribute during the acquisition of lymphatic identity is not understood.
Katarzyna Koltowska +7 more
doaj +2 more sources
Restoration of retinal regenerative potential of Müller glia by disrupting intercellular Prox1 transfer [PDF]
Nature CommunicationsIndividuals with retinal degenerative diseases struggle to restore vision due to the inability to regenerate retinal cells. Unlike cold-blooded vertebrates, mammals lack Müller glia (MG)-mediated retinal regeneration, indicating the limited regenerative ...
Eun Jung Lee +15 more
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Prospero-related homeobox 1 (Prox1) at the crossroads of diverse pathways during adult neural fate specification [PDF]
Frontiers in Cellular Neuroscience, 2015 Over the last decades, adult neurogenesis in the central nervous system (CNS) has emerged as a fundamental process underlying physiology and disease. Recent evidence indicates that the homeobox transcription factor Prox1 is a critical intrinsic regulator
Athanasios eStergiopoulos +2 more
doaj +2 more sources