Restoration of retinal regenerative potential of Müller glia by disrupting intercellular Prox1 transfer [PDF]
Nature CommunicationsIndividuals with retinal degenerative diseases struggle to restore vision due to the inability to regenerate retinal cells. Unlike cold-blooded vertebrates, mammals lack Müller glia (MG)-mediated retinal regeneration, indicating the limited regenerative ...
Eun Jung Lee +15 more
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PROX1 Expression in Resected Non-Small Cell Lung Cancer: Immunohistochemical Profile and Clinicopathological Correlates [PDF]
Medical SciencesBackground/Objectives: PROX1 (prospero homeobox 1) is a transcription factor involved in lymphangiogenesis and cellular differentiation. Its role in cancer biology appears to be highly context-dependent, with it exhibiting both tumor-promoting and ...
Evangelia Ntikoudi +8 more
doaj +4 more sources
Altered regulation of Prox1-gene-expression in liver tumors [PDF]
BMC Cancer, 2008 Background Prospero-related homeobox 1 (Prox1) transcription factor was described as a tumor-suppressor gene in liver tumors. In contrast, Prox1 knock out in murine embryos drastically reduces proliferation of hepatoblasts.
Füzesi Laszlo +7 more
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PROX1 Promotes Metabolic Adaptation and Fuels Outgrowth of Wnthigh Metastatic Colon Cancer Cells [PDF]
Cell Reports, 2014 The Wnt pathway is abnormally activated in the majority of colorectal cancers, and significant knowledge has been gained in understanding its role in tumor initiation.
Simone Ragusa +17 more
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Prox1 and FOXC2 act as regulators of lymphangiogenesis and angiogenesis in oral squamous cell carcinoma. [PDF]
PLoS ONE, 2014 Prospero homeobox 1 (Prox1) and forkhead box (FOX) C2 regulate angiogenesis and/or lymphangiogenesis. However, the detailed role and function of Prox1 and FOXC2 in cancer remains controversial.
Tomonori Sasahira +7 more
doaj +3 more sources
Prospero-related homeobox protein 1 (Prox1) enhances myelin sheath regeneration in injured sciatic nerve [PDF]
IBRO Neuroscience ReportsBackground: Peripheral nerve injury (PNI), such as sciatic nerve injury (SNI), often results in poor functional recovery due to myelin damage, which critically impairs nerve regeneration.
Linlin Jie +6 more
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Hydrostatic Pressures in Lymphatic Networks of the Mouse. [PDF]
MicrocirculationABSTRACT Objective Current research on the lymphatic system makes nearly exclusive use of mouse models because that species is highly amenable to genetic manipulation. However, the lack of information about intraluminal hydrostatic pressures in mouse lymphatic networks limits the ability of investigators, for both in vivo and ex vivo studies, to ...
Davis MJ.
europepmc +2 more sources
Prox1 Is Linked to Metastasis and Poor Prognosis by Promoting Lymphangiogenesis in Melanoma [PDF]
Clinical, Cosmetic and Investigational DermatologyChen Cao,1,* Wei Ju,2,* Ling-Qiao Li,1 De-Ming Li,2 Wei Zhang,2 Xi-Hu Yang,3 Zhi-Xin Yan4 1Department of Burn and Plastic Surgery, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu Province, People’s Republic of ...
Cao C +6 more
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Cell Reports, 2014 Colorectal cancer (CRC) initiation and growth is often attributed to stem cells, yet little is known about the regulation of these cells. We show here that a subpopulation of Prox1-transcription-factor-expressing cells have stem cell activity in ...
Zoltán Wiener +11 more
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PROX1 is an early driver of lineage plasticity in prostate cancer [PDF]
The Journal of Clinical InvestigationLineage plasticity is recognized as a critical determinant of lethality and resistance to AR pathway inhibitors in prostate cancer. Lineage plasticity is a continuum, ranging from AR activity-low tumors, AR-null tumors that do not express a ...
Zhi Duan +45 more
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