Prognostic relevance of prospero homeobox 1 and metastasis tumor antigen 1 in patients with malignant salivary gland tumors: a clinicopathological study [PDF]
European Journal of Medical ResearchObjective The current study aimed to investigate the prognostic relevance of PROX1, and MTA1 in salivary gland carcinomas. Methods In a retrospective study on 45 cases diagnosed with salivary gland carcinoma, PROX1 and MTA1 immunoexpressions were ...
Samar Soliman +2 more
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Cell Reports, 2015 Lymphatic vessels arise chiefly from preexisting embryonic veins. Genetic regulators of lymphatic fate are known, but how dynamic cellular changes contribute during the acquisition of lymphatic identity is not understood.
Katarzyna Koltowska +7 more
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Epigenetic Derepression of PROX1 Promotes Neuroendocrine Prostate Cancer Progression. [PDF]
Cancer ResVenkadakrishnan VB +9 more
europepmc +3 more sources
Cytosolic Phospholipase A2α and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation [PDF]
, 2013 Acknowledgments: We thank Dr. Robert Barkley and Charis Uhlson for mass spectrometry analysis. Funding: This work was supported by grants from the National Institutes of Health HL34303 (to C.C.L., R.C.M. and D.L.B), DK54741 (to J.V.B.), GM5322 (to D.L.W.)
Bonventre, Joseph V. +9 more
core +21 more sources
Case Report: Surgical management of primary lymphedema with a novel PROX1 mutation involving upper and lower limbs. [PDF]
Front GenetChen J +6 more
europepmc +3 more sources
Specific Temporal Requirement of Prox1 Activity During Pancreatic Acinar Cell Development
Gastro Hep Advances, 2022 Background and Aims: An interactive regulatory network assembled through the induction and downregulation of distinct transcription factors governs acinar cell maturation.
Angelica S. Martinez-Ramirez +7 more
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Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription. [PDF]
PLoS ONE, 2013 Cholesterol 7α-hydroxylase (CYP7A1) catalyzes the first and rate-limiting step in the classical pathway of bile acids synthesis in liver and is crucial for maintaining lipid homeostasis.
Huafang Ouyang +4 more
doaj +1 more source
Cells, 2023 Breast cancer is one of the most lethal malignancies in women worldwide and is characterized by rapid growth and low survival rates, despite advances in tumor biology and therapies.
Artemis Michail +4 more
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Opposing regulation of PROX1 by interleukin-3 receptor and NOTCH directs differential host cell fate reprogramming by Kaposi sarcoma herpes virus. [PDF]
PLoS Pathogens, 2012 Lymphatic endothelial cells (LECs) are differentiated from blood vascular endothelial cells (BECs) during embryogenesis and this physiological cell fate specification is controlled by PROX1, the master regulator for lymphatic development.
Jaehyuk Yoo +14 more
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High PROX1 expression in gastric cancer predicts better survival. [PDF]
PLoS ONE, 2017 PROX1 is a transcription factor involved in the development of various organs. It has also an important function in colorectal cancer progression. The aim of this study was to investigate the prognostic role of PROX1 expression in gastric cancer.We ...
Alli Laitinen +5 more
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