High tissue MMP14 expression predicts worse survival in gastric cancer, particularly with a low PROX1 [PDF]
Cancer Medicine, 2019 Matrix metalloproteinase 14 (MMP14), a membrane‐associated matrix metalloproteinase, has been shown to influence the invasion and metastasis of several solid tumors.
Aaro Kasurinen +10 more
doaj +2 more sources
Long Non-Coding PROX1-AS1 Expression Correlates with Renal Cell Carcinoma Metastasis and Aggressiveness [PDF]
Non-Coding RNA, 2021 Long non-coding RNAs (lncRNAs) can be specifically expressed in different tissues and cancers. By controlling the gene expression at the transcriptional and translational levels, lncRNAs have been reported to be involved in tumor growth and metastasis ...
Magdalena Rudzinska +10 more
doaj +2 more sources
Prognostic relevance of prospero homeobox 1 and metastasis tumor antigen 1 in patients with malignant salivary gland tumors: a clinicopathological study [PDF]
European Journal of Medical ResearchObjective The current study aimed to investigate the prognostic relevance of PROX1, and MTA1 in salivary gland carcinomas. Methods In a retrospective study on 45 cases diagnosed with salivary gland carcinoma, PROX1 and MTA1 immunoexpressions were ...
Samar Soliman +2 more
doaj +2 more sources
PLoS Pathogens, 2021 Increasing evidence suggests that Kaposi's sarcoma (KS) arises from Kaposi's sarcoma-associated herpesvirus (KSHV)-infected mesenchymal stem cells (MSCs) through mesenchymal-to-endothelial transition (MEndT).
Yao Ding +4 more
doaj +3 more sources
Identification and Validation of Epithelial Cell Centre Regulatory Transcription Factors in the Gastric Cancer Microenvironment [PDF]
International Journal of General MedicineGuomiao Su,1,* Juan Wang,2,* Shiyue Liu,1,* Xiaonan Fu,1 Yanxi Li,1 Guoqing Pan1 1Department of Pathology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yun Nan, People’s Republic of China; 2Clinical Laboratory, Yunnan
Su G, Wang J, Liu S, Fu X, Li Y, Pan G
doaj +2 more sources
Cytosolic Phospholipase A2α and Eicosanoids Regulate Expression of Genes in Macrophages Involved in Host Defense and Inflammation [PDF]
, 2013 Acknowledgments: We thank Dr. Robert Barkley and Charis Uhlson for mass spectrometry analysis. Funding: This work was supported by grants from the National Institutes of Health HL34303 (to C.C.L., R.C.M. and D.L.B), DK54741 (to J.V.B.), GM5322 (to D.L.W.)
Bonventre, Joseph V. +9 more
core +17 more sources
Specific Temporal Requirement of Prox1 Activity During Pancreatic Acinar Cell Development
Gastro Hep Advances, 2022 Background and Aims: An interactive regulatory network assembled through the induction and downregulation of distinct transcription factors governs acinar cell maturation.
Angelica S. Martinez-Ramirez +7 more
doaj +1 more source
Prox1 directly interacts with LSD1 and recruits the LSD1/NuRD complex to epigenetically co-repress CYP7A1 transcription. [PDF]
PLoS ONE, 2013 Cholesterol 7α-hydroxylase (CYP7A1) catalyzes the first and rate-limiting step in the classical pathway of bile acids synthesis in liver and is crucial for maintaining lipid homeostasis.
Huafang Ouyang +4 more
doaj +1 more source
Opposing regulation of PROX1 by interleukin-3 receptor and NOTCH directs differential host cell fate reprogramming by Kaposi sarcoma herpes virus. [PDF]
PLoS Pathogens, 2012 Lymphatic endothelial cells (LECs) are differentiated from blood vascular endothelial cells (BECs) during embryogenesis and this physiological cell fate specification is controlled by PROX1, the master regulator for lymphatic development.
Jaehyuk Yoo +14 more
doaj +1 more source
PLoS ONE, 2014 The transcription factor PROX1 (prospero homeobox 1) has a critical role in the development of various organs, and has been implicated in both oncogenic and tumor-suppressive functions in human cancers.
Tao Lv +9 more
doaj +1 more source