The intestinal lymphatic system: Functions and metabolic implications [PDF]
, 2019 The lymphatic system of the gut plays important roles in the transport of dietary lipids, as well as in immunosurveillance and removal of interstitial fluid.
Cifarelli, Vincenza, Eichmann, Anne
core +2 more sources
Altered regulation of Prox1-gene-expression in liver tumors
BMC Cancer, 2008 Background Prospero-related homeobox 1 (Prox1) transcription factor was described as a tumor-suppressor gene in liver tumors. In contrast, Prox1 knock out in murine embryos drastically reduces proliferation of hepatoblasts.
Füzesi Laszlo +7 more
doaj +1 more source
T Cell Migration from Inflamed Skin to Draining Lymph Nodes Requires Intralymphatic Crawling Supported by ICAM-1/LFA-1 Interactions. [PDF]
, 2017 T cells are the most abundant cell type found in afferent lymph, but their migration through lymphatic vessels (LVs) remains poorly understood. Performing intravital microscopy in the murine skin, we imaged T cell migration through afferent LVs in vivo ...
Coles, Marc +10 more
core +3 more sources
Human iPSC differentiation to retinal organoids in response to IGF1 and BMP4 activation is line- and method-dependent [PDF]
, 2020 Induced pluripotent stem cell (iPSC)‐derived retinal organoids provide a platform to study human retinogenesis, disease modeling, and compound screening.
Armstrong, Lyle +7 more
core +2 more sources
Active repression of cell fate plasticity by PROX1 safeguards hepatocyte identity and prevents liver tumorigenesis. [PDF]
Nat GenetLim B +28 more
europepmc +2 more sources
Homeobox genes in normal and abnormal vasculogenesis [PDF]
, 2008 Homeobox containing genes are a family of transcription factors regulating normal development and controlling primary cellular processes (cell identity, cell division and differentiation) recently enriched by the discovery of their interaction with ...
Cantile M +3 more
core +1 more source
PLoS ONE, 2022 PurposeGreater muscle fragility is thought to cause the exhaustion of the muscle stem cells during successive degeneration/repair cycles, leading to muscle wasting and weakness in Duchenne muscular dystrophy.
Alexandra Monceau +7 more
doaj +2 more sources
The Role of PROX1 in Neoplasia: A Key Player Often Overlooked
Diagnostics, 2022 The human PROX1 gene (Prospero homeobox gene 1) is a member of the homeobox transcription factor family. PROX1 plays a key role in the development of the lymphatic system and is primarily used as a lymphatic vessel marker.
Evangelia Ntikoudi +4 more
doaj +1 more source
Role of Prox1 in the Transforming Ascending Thin Limb of Henle's Loop during Mouse Kidney Development. [PDF]
PLoS ONE, 2015 The homeobox transcription factor Prox1 is critical to the development of many embryonic organs and tissues, although current understanding of its expression in the developing renal medulla is limited.
Yu-Mi Kim +7 more
doaj +1 more source
Roles of TGFβ and FGF signals during growth and differentiation of mouse lens epithelial cell in vitro. [PDF]
, 2017 Transforming growth factor β (TGFβ) and fibroblast growth factor (FGF) signaling pathways play important roles in the proliferation and differentiation of lens epithelial cells (LECs) during development.
Gong, Xiaohua +5 more
core +2 more sources