Results 51 to 60 of about 13,248 (198)

Prox1 Inhibits Proliferation and Is Required for Differentiation of the Oligodendrocyte Cell Lineage in the Mouse.

PLoS ONE, 2015
Central nervous system injury induces a regenerative response in ensheathing glial cells comprising cell proliferation, spontaneous axonal remyelination, and limited functional recovery, but the molecular mechanisms are not fully understood.
Kentaro Kato, Daijiro Konno, Martin Berry, Fumio Matsuzaki, Ann Logan, Alicia Hidalgo   +5 more
doaj   +1 more source

Canal cristae growth and fiber extension to the outer hair cells of the mouse ear require Prox1 activity.

PLoS ONE, 2010
BackgroundThe homeobox gene Prox1 is required for lens, retina, pancreas, liver, and lymphatic vasculature development and is expressed in inner ear supporting cells and neurons.Methodology/principal findingsWe have investigated the role of Prox1 in the ...
Bernd Fritzsch, Miriam Dillard, Alfonso Lavado, Natasha L Harvey, Israt Jahan   +4 more
doaj   +1 more source

Differential responses to lithium in hyperexcitable neurons from patients with bipolar disorder. [PDF]

, 2015
Bipolar disorder is a complex neuropsychiatric disorder that is characterized by intermittent episodes of mania and depression; without treatment, 15% of patients commit suicide.
, Alda, Martin, Boyer, Leah, Brennand, Kristen J., Calabrese, Joseph R., Diffenderfer, Kenneth E., Eames, Tameji, Gage, Fred H., Kelsoe, John R., Kim, Yongsung, Marchetto, Maria C., McCarthy, Michael J., Mertens, Jerome, Mi, Shuangli, Nievergelt, Caroline M., Nurnberger, John I., Oedegaard, Ketil J., Pham, Son, Schafer, Simon T., Soltani, Sheila, Wang, Qiu-Wen, Yang, Bo, Yao, Jun, Yu, Diana X., Zandi, Peter P., Zhang, Jian, Zheng, Yi   +26 more
core   +1 more source

Human iPSC‐Derived Mononuclear Phagocytes Improve Cognition and Neural Health across Multiple Mouse Models of Aging and Alzheimer's Disease

Advanced Science, EarlyView.
Short‐term intravenous treatments with iPSC‐derived mononuclear phagocytes (iMPs) improve cognitive decline and neural health in two mouse models of aging and in the 5xFAD mouse model of Alzheimer's disease. iMPs reduce levels of serum amyloid proteins that increase in aging and improve the health of hippocampal microglia and mossy cells.
V. Alexandra Moser, Luz Jovita Dimas‐Harms, Rachel M. Lipman, Jake Inzalaco, Shaughn Bell, Michelle Alcantara, Erikha Valenzuela, George Lawless, Simion Kreimer, Sarah J. Parker, Helen S. Goodridge, Clive N. Svendsen   +11 more
wiley   +1 more source

Hematopoietic stem cell regeneration through paracrine regulation of the Wnt5a/Prox1 signaling axis

The Journal of Clinical Investigation, 2022
The crosstalk between the BM microenvironment (niche) and hematopoietic stem cells (HSCs) is critical for HSC regeneration. Here, we show that in mice, deletion of the Fanconi anemia (FA) genes Fanca and Fancc dampened HSC regeneration through direct ...
Qiqi Lin, Limei Wu, Srinivas Chatla, Fabliha A. Chowdhury, Neha Atale, Jonathan Joseph, Wei Du   +6 more
doaj   +1 more source

The Pathogenic Roles of Local Vitamin D Metabolism Defect in Valve Inflammation and Calcification

Advanced Science, EarlyView.
This study identifies the valvular interstitial cell populations responsible for valvular calcification induced by hyperphosphatemia and likely aging, uncovers local vitamin D metabolism defect‐induced inflammation as a critical pathogenic factor of calcific aortic valve disease, and highlights active vitamin D and ERK inhibitor as potential preventive
Ruichen Yang, Chong Han, Yangli Xie, Shoutao Qiu, Shaoyang Zhang, Jingjia He, Zejian Wang, Zhenlin Zhang, Huijuan Liu, Lin Chen, Baojie Li   +10 more
wiley   +1 more source

Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm’s Canal Reporter Rat

Scientific Reports, 2017
The lymphatic system plays a key role in tissue fluid homeostasis, immune cell trafficking, and fat absorption. We previously reported a bacterial artificial chromosome (BAC)-based lymphatic reporter mouse, where EGFP is expressed under the regulation of
Eunson Jung, Daniel Gardner, Dongwon Choi, Eunkyung Park, Young Jin Seong, Sara Yang, Jorge Castorena-Gonzalez, Antoine Louveau, Zhao Zhou, Gene K. Lee, David P. Perrault, Sunju Lee, Maxwell Johnson, George Daghlian, Maria Lee, Yeo Jin Hong, Yukinari Kato, Jonathan Kipnis, Michael J. Davis, Alex K. Wong, Young-Kwon Hong   +20 more
doaj   +1 more source

DLL4 promotes continuous adult intestinal lacteal regeneration and dietary fat transport. [PDF]

, 2015
The small intestine is a dynamic and complex organ that is characterized by constant epithelium turnover and crosstalk among various cell types and the microbiota.
Barker, Benedito, Cansaran Saygili Demir, Christophe Cisarovsky, Freddy Radtke, Humphrey, Jeremiah Bernier-Latmani, Jurisic, Kamba, Malanchi, Marine Bruand, Muriel Jaquet, Nowotschin, Olivier Dormond, Prewett, Rui Benedito, Sanjiv A. Luther, Shutter, Simone Ragusa, Srinivas, Stefanie Siegert, Suzel Davanture, Tatiana V. Petrova, Womack   +23 more
core   +2 more sources

Deciphering the Role and Mechanism of Decidual Monocyte‐Derived Macrophage Infiltration in Obstetric Antiphospholipid Syndrome at Single‐Cell Resolution

Advanced Science, EarlyView.
This study uncovers a novel mechanism and therapeutic targets in obstetric antiphospholipid syndrome (OAPS). Antiphospholipid antibody/ß2‐glycoprotein I complex boosts CCL2 and TNF‐α expression in decidual macrophages via TLR4‐NF‐κB. CCL2 accumulates on endothelial surfaces via ACKR1, recruiting monocyte‐derived CCR2+ macrophages, driving inflammation,
Rui Gao, Pingying Qing, Hanxiao Chen, Zhengyan Hu, Qiaoran Yang, Chenyang Lu, Huimin Liu, Rujun Zeng, Yuanting Tang, Fan Yu, Jinbiao Han, Xin Liao, Xun Zeng, Lang Qin   +13 more
wiley   +1 more source

The Role of Prox1 during Mouse Pancreas Organogenesis [PDF]

, 2010
The pancreas is a mixed (exocrine and endocrine) glandular organ that is important for food digestion and glucose homeostasis. Developmental anomalies or disorders that affect normal pancreas homeostasis may cause various life-threatening diseases such ...
Kilic Berkmen, G. (Gamze)
core   +1 more source