The Fanconi syndrome of cystinosis: insights into the pathophysiology
The Turkish Journal of Pediatrics, 2002 Cystinosis is a lysosomal storage disease, and is one of the most common causes of the Fanconi syndrome. In vitro studies of the cystine-loaded tubule provided insights into the pathophysiology of the proximal tubular defect.
Abdullah Sakarcan
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Colocalization of GLUT2 glucose transporter, sodium/glucose cotransporter, and gamma-glutamyl transpeptidase in rat kidney with double-peroxidase immunocytochemistry. [PDF]
, 1992 Glucose is reabsorbed from the glomerular filtrate in the proximal segment of the renal tubule in two stages. The first stage is uphill transport across the brush border membrane by Na(+)-glucose cotransport and the second stage is downhill transport ...
Cramer, SC +3 more
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Immunohistochemical distributions of hgf and pcna in the kidneys of diabetic and non-diabetic mice [PDF]
Kafkas Universitesi Veteriner Fakültesi Dergisi, 2020 Diabetes mellitus is a systemic disease that causes functional disorders in various organs and systems. In this study, we investigated the immunohistochemical localization of hepatocyte growth factor (HGF) and proliferating cell nuclear antigen (PCNA) in
Turgay DEPREM +5 more
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Three-dimensional structure of basal body triplet revealed by electron cryo-tomography. [PDF]
, 2011 Basal bodies and centrioles play central roles in microtubule (MT)-organizing centres within many eukaryotes. They share a barrel-shaped cylindrical structure composed of nine MT triplet blades.
Agard, David A +3 more
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Current Perspective on the Location and Function of Gamma- Aminobutyric Acid (GABA) and its Metabolic Partners in the Kidney. [PDF]
, 2014 Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter located in the mammalian central nervous system, which binds to GABAA and GABAB receptors to mediate its neurological effects.
Dunn, Kadeshia +3 more
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Biomolecules & Biomedicine, 2014 The aim of this research was to assess the reactive changes of rat proximal tubules caused by gentamicin and the effect of relatively low doses of melatonin. 48 adult male Wistar rats were distributed into six groups of equal size which all received one
Dina Kapić +3 more
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Adefovir-induced Fanconi syndrome associated with osteomalacia [PDF]
Clinical and Molecular Hepatology, 2018 Fanconi syndrome is a dysfunction of the proximal renal tubules that results in impaired reabsorption and increased urinary loss of phosphate and other solutes. The pathophysiology of drug-induced Fanconi syndrome is unclear. Here we report the case of a
Samel Park +10 more
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Bioengineered Cystinotic Kidney Tubules Recapitulate a Nephropathic Phenotype
Cells, 2022 Nephropathic cystinosis is a rare and severe disease caused by disruptions in the CTNS gene. Cystinosis is characterized by lysosomal cystine accumulation, vesicle trafficking impairment, oxidative stress, and apoptosis. Additionally, cystinotic patients
Elena Sendino Garví +2 more
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Ontogeny of proximal tubule acidification
Kidney International, 1995 The proximal tubule is responsible for the reabsorption of 80% of the filtered load of bicarbonate in adults. Proximal tubule bicarbonate reabsorption is affected by a number of hormones, acid-base balance, and the extracellular fluid volume status [1]. The adult proximal tubule thus plays a central role in acid-base homeostasis.
Baum, Michel, Quigley, Raymond
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Proximal Tubule Dysfunction Secondary to Salicylate Intoxication [PDF]
Global Pediatric Health, 2022 Aspirin overdose is still a common cause of presentation to the emergency department and is commonly seen in the setting of one-time, accidental or intentional ingestion of large amounts of salicylate-containing compounds, though can occur with long-term ingestion of super-therapeutic doses of medications.
Zachary C. Taylor +2 more
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