Results 101 to 110 of about 1,549,882 (213)

Altered Ca2+ homeostasis induces Calpain-Cathepsin axis activation in sporadic Creutzfeldt-Jakob disease

Acta Neuropathologica Communications, 2017
Sporadic Creutzfeldt-Jakob disease (sCJD) is the most prevalent form of human prion disease and it is characterized by the presence of neuronal loss, spongiform degeneration, chronic inflammation and the accumulation of misfolded and pathogenic prion ...
Franc Llorens, Katrin Thüne, Beata Sikorska, Matthias Schmitz, Waqas Tahir, Natalia Fernández-Borges, Maria Cramm, Nadine Gotzmann, Margarita Carmona, Nathalie Streichenberger, Uwe Michel, Saima Zafar, Anna-Lena Schuetz, Ashish Rajput, Olivier Andréoletti, Stefan Bonn, Andre Fischer, Pawel P. Liberski, Juan Maria Torres, Isidre Ferrer, Inga Zerr   +20 more
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Contribution à l'étude de la diversité biochimique et biologique des agents des encéphalopathies spongiformes transmissibles [PDF]

, 2012
Les encéphalopathies spongiformes transmissibles (EST) sont caractérisées par l'accumulation d'une protéine, la PrPSc, dans le système nerveux central des individus malades.
Cassard, Hervé, Cassard, Hervé, H.
core  

Development of a sensitive cell culture system to assess prion infectivity and the efficacy of prion decontamination technologies

, 2012
Creutzfeldt-Jakob disease (CJD) can be iatrogenically transmitted during transplants, grafts and transfusions from CJD infected donors and also contaminated surgical instruments.
Secker, Thomas
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Femtogram Electrochemical Sensing of Prion Proteins Using Quantum Dots

International Journal of Electrochemical Science, 2013
The prion protein (PrP) is involved in neurodegeneration via its conversion from the normal cellular form, PrPC, to the infectious form, PrPSc, which is the causative agent of the transmissible spongiform encephalopathies (TSEs) including Creutzfeldt ...
Pavlina Sobrova, Marketa Ryvolova, Vladimir Pekarik, Jaromir Hubalek, Vojtech Adam, Rene Kizek   +5 more
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A comparative analysis between PrPc and PrPsc to determine the structure‐function relationship of protein misfolding in Scrapie prion disease

The FASEB Journal, 2019
The Minnetonka MSOE Center for BioMolecular Modeling SMART Team used 3D modeling and printing technology to examine structure‐function relationships of PrPsc. Scrapies is caused by prions, misfolded proteins in animals and humans, resulting in the development of fatal neurodegenerative encephalitis.
Alison Peterson, Catherine Borisova, Priscilla Bunday, Meili Gong, Daniela Hernandez Merlin, Nicholas Kachkovsky, Eli Quist, Ming Ying Yeoh   +7 more
openaire   +1 more source

Prion degradation pathways: Potential for therapeutic intervention [PDF]

, 2015
Prion diseases are fatal neurodegenerative disorders. Pathology is closely linked to the misfolding of native cellular PrP(C) into the disease-associated form PrP(Sc) that accumulates in the brain as disease progresses. Although treatments have yet to be
McKinnon, C, Tabrizi, SJ, Goold, R
core  

Characterisation of Bombyx mori odorant-binding proteins reveals that a general odorant-binding protein discriminates between sex pheromone components [PDF]

, 2009
In many insect species, odorant-binding proteins (OBPs) are thought to be responsible for the transport of pheromones and other semiochemicals across the sensillum lymph to the olfactory receptors (ORs) within the antennal sensilla.
Field, L.M., Pickett, J. A., Dufour, S. G. L., Zhou, J.J., Keep, N. H., Dufour, Samuel, Field, Linda M., He, X., Hooper, A.M., Hooper, A. M., Pickett, John A., Pickett, J.A., He, Xiaoli, Dufour, S., Field, L. M., Keep, Nicholas H., Robertson, G., Robertson, Giles, Zhou, J-J., Hooper, Antony M., Zhou, Jing-Jiang   +20 more
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Prominent Stress Response of Purkinje Cells in Creutzfeldt–Jakob Disease

Neurobiology of Disease, 2001
To examine the role of stress-related 70-kDa heat shock proteins (Hsp-s) in Creutzfeldt–Jakob disease (CJD), we performed immunocytochemistry to detect Hsp-72 and Hsp-73, together with the abnormal (PrPSc) and the presumed cellular form (PrPC) of the ...
Gábor G. Kovács, István Kurucz, Herbert Budka, Csaba Ádori, Ferenc Müller, Péter Ács, Stefan Klöppel, Hermann M. Schätzl, R.John Mayer, Lajos László   +9 more
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Generation of monoclonal antibody that distinguishes PrPSc from PrPC and neutralizes prion infectivity [PDF]

, 2009
To establish PrPSc-specific mAbs, we immunized Prnp-/- mice with PrPSc purified from prion-infected mice. Using this approach, we obtained mAb 6H10, which reacted with PrPSc treated with proteinase K, but not with PrPSc pretreated with more than 3 M ...
Shinagawa, Morikazu, Morikazu Shinagawa, Horiuchi, Motohiro, Ayako Karino, Motohiro Horiuchi, Ishiguro, Naotaka, Karino, Ayako, Kumiko Kimura, Hidefumi Furuoka, Kimura, Kumiko, Furuoka, Hidefumi, Naotaka Ishiguro   +11 more
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Magnetic microparticle-based multimer detection system for the detection of prion oligomers in sheep

International Journal of Nanomedicine, 2015
Kuntaek Lim,1 Su Yeon Kim,2 Byoungsub Lee,1 Christiane Segarra,3 Sungmin Kang,1 Youngran Ju,2 Mary Jo Schmerr,4 Joliette Coste,3 Sang Yun Kim,5 Takashi Yokoyama,6 Seong Soo A An7 1Department of Research and Development, PeopleBio Inc., 2Department of ...
Lim K, Kim SY, Lee B, Segarra C, Kang S, Ju YR, Schmerr MJ, Coste J, Kim SY, Yokoyama T, An SSA   +10 more
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