Results 111 to 120 of about 1,549,882 (213)

Molecular signatures in prion disease: altered death receptor pathways in a mouse model

Journal of Translational Medicine
Background Prion diseases are transmissible and fatal neurodegenerative diseases characterized by accumulation of misfolded prion protein isoform (PrPSc), astrocytosis, microgliosis, spongiosis, and neurodegeneration.
Ranjit Kumar Giri
doaj   +1 more source

Methionine Sulfoxides on PrPSc: A Prion-Specific Covalent Signature [PDF]

, 2008
Prion diseases are fatal neurodegenerative disorders believed to be transmitted by PrPSc, an aberrant form of the membrane protein PrPC. In the absence of an established form-specific covalent difference, the infectious properties of PrPSc were uniquely ...
Moshel, Ofra, Canello, T., Moshel, O., Xanthopoulos, Konstantinos, Gasset, M., Sklaviadis, T., Engelstein, Roni, Sklaviadis, Theodorus, Xanthopoulos, K., Juanes, Maria E., Langeveld, Jan, Engelstein, R., Canello, Tamar, Gabizon, R., Gabizon, Ruth, Langeveld, J.P.M.   +15 more
core   +1 more source

RESEARCH AND DEVELOPMENT CONTROL METHOD PATHOGENIC PRION INFECTIONS SECONDARY RAW MEAT INDUSTRY

Теория и практика переработки мяса, 2016
Highly sensitive and specific method for identification of pathogenic prion protein was developed. It was found that the water-soluble fractions of beef proteins and plasma proteins of farm animals are normal prion proteins in cattle.
A. Y. Prosekov, O. V. Kriger
doaj   +1 more source

Some physico-chemical parameters that influence proteinase K resistance and the infectivity of PrPSc after high pressure treatment [PDF]

, 2005
Crude brain homogenates of terminally diseased hamsters infected with the 263 K strain of scrapie (PrPSc) were heated and/or pressurized at 800 MPa at 60 degrees C for different times (a few seconds or 5, 30, 120 min) in phosphate-buffered saline (PBS ...
Fernandez Garcia, A., Büttner, Mathias, Butz, Peter, Heindl, P., Pfaff, Eberhard, Tauscher, B., Buttlar, Heiner von   +6 more
core   +1 more source

Keratinolytic Properties of PrPSc-degrading Enzyme E77 [PDF]

, 2009
It is suggested that the keratinolytic activity of proteases are associated with the degrading activity of the abnormal type prion protein (PrPSc). We tried to analyze the keratinolytic properties of the PrPSc- degrading enzyme E77.
Takasugi, Mikako, 98448, 98447, 98449, Goto, Masatoshi, Mitsuiki, Shinji, 98446, Oka, Tatsuzo, 98445, Kanouchi, Hiroaki   +9 more
core   +1 more source

Die Rolle von PrPC in der neuronalen Differenzierung und die Ausbreitung der infektiösen Isoform PrPSc durch Mikrovesikel [PDF]

, 2008
Prion diseases or transmissible spongiform encephalopathies (TSEs) are rare neurological disorders that may be of genetic or infectious origin, but most frequently occur sporadically in humans. Their outcome is invariably fatal.
Barenco Montrasio, Maria Grazia
core  

Co-existence of Distinct Prion Types Enables Conformational Evolution of Human PrPSc by Competitive Selection

, 2013
The unique phenotypic characteristics of mammalian prions are thought to be encoded in the conformation of pathogenic prion proteins (PrPSc). The molecular mechanism responsible for the adaptation, mutation, and evolution of prions observed in cloned ...
Haldiman, T., Cohen, Y., Blevins, J., Cohen, M.L., Qing, L., Safar, J.G., Kim, C., Chen, W., Langeveld, J.P.M., Telling, G.C., Kong, Q.   +10 more
core   +1 more source

Selection and characterisation of PrPSc-specific aptamers

, 2006
Titelblatt und Inhaltsverzeichnis Einleitung Problemstellung Material und Methoden Ergebnisse Diskussion Ausblick Zusammenfassung Literaturverzeichnis AnhangUnter Prionkrankheiten werden eine Reihe an fatalen, neurodegenerativen ...
Höhn, Britta
core   +1 more source

What Is Our Current Understanding of PrPSc-Associated Neurotoxicity and Its Molecular Underpinnings?

, 2017
The prion diseases are a collection of fatal, transmissible neurodegenerative diseases that cause rapid onset dementia and ultimately death. Uniquely, the infectious agent is a misfolded form of the endogenous cellular prion protein, termed PrPSc ...
Mark Halliday, Daniel Hughes
core   +1 more source

A Protein Misfolding Shaking Amplification-based method for the spontaneous generation of hundreds of bona fide prions

Nature Communications
Prion diseases are a group of rapidly progressing neurodegenerative disorders caused by the misfolding of the endogenous prion protein (PrPC) into a pathogenic form (PrPSc).
Hasier Eraña, Cristina Sampedro-Torres-Quevedo, Jorge M. Charco, Carlos M. Díaz-Domínguez, Francesca Peccati, Maitena San-Juan-Ansoleaga, Enric Vidal, Nuno Gonçalves-Anjo, Miguel A. Pérez-Castro, Ezequiel González-Miranda, Patricia Piñeiro, Leire Fernández-Veiga, Josu Galarza-Ahumada, Eva Fernández-Muñoz, Guiomar Perez de Nanclares, Glenn Telling, Mariví Geijo, Gonzalo Jiménez-Osés, Joaquín Castilla   +18 more
doaj   +1 more source