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[Establishment of a protein misfolding cyclic amplification for PrPSc].
Zhonghua shi yan he lin chuang bing du xue za zhi = Zhonghua shiyan he linchuang bingduxue zazhi = Chinese journal of experimental and clinical virology, 2009To establish a methodology of protein misfolding cyclic amplification (PMCA) and utilize in the detection of PrP(Sc) in brain tissues from prion diseases.Different amounts of Scrapie 263K agent bulk were mixed with brain homogenates of health hamsters and treated with repeated incubation/sonication for 10 to 15 cycles. The proteinase K-resistant PrP(Sc)
Jun, Han +6 more
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Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2007
Prion diseases are associated with accumulation of strain-dependent biochemically distinct, disease-related isoforms (PrP(Sc)) of host-encoded prion protein (PrP(C)). PrP(Sc) is characterised by increased beta-sheet content, detergent insolubility and protease resistance.
Khalili-Shirazi, A +9 more
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Prion diseases are associated with accumulation of strain-dependent biochemically distinct, disease-related isoforms (PrP(Sc)) of host-encoded prion protein (PrP(C)). PrP(Sc) is characterised by increased beta-sheet content, detergent insolubility and protease resistance.
Khalili-Shirazi, A +9 more
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Mapping the interactions between prion protein (PrPC) and prion protein fibrils (PrPSc)
Biophysical Journal, 2023Alyssa M. Thallemer +2 more
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Current Neurovascular Research, 2009
In the variant form of Creutzfeldt-Jakob disease (vCJD), 'florid' deposits of the protease resistant form of prion protein (PrP(sc)) were aggregated around the cerebral blood vessels suggesting the possibility that prions may spread into the brain via the cerebral microcirculation.
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In the variant form of Creutzfeldt-Jakob disease (vCJD), 'florid' deposits of the protease resistant form of prion protein (PrP(sc)) were aggregated around the cerebral blood vessels suggesting the possibility that prions may spread into the brain via the cerebral microcirculation.
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2004
Main histopathological hallmarks of TSEs are severe spongiosis, gliosis and brain tissue deposition of an abnormal isoform (PrPSc or PrPres) of the normal cellular prion protein (PrPC or PrPsen). Despite identical primary sequences, PrPC and PrPSc isoforms differ in their tertiary structures [1] and as a consequence, they exhibit distinct ...
Gregory J. Raymond, Joëlle Chabry
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Main histopathological hallmarks of TSEs are severe spongiosis, gliosis and brain tissue deposition of an abnormal isoform (PrPSc or PrPres) of the normal cellular prion protein (PrPC or PrPsen). Despite identical primary sequences, PrPC and PrPSc isoforms differ in their tertiary structures [1] and as a consequence, they exhibit distinct ...
Gregory J. Raymond, Joëlle Chabry
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
exaly
DMSO inhibits the aggregation of the prion proteins (PRPSC) into amyloid rods
Neuroscience Letters, 1997G. Shaked, A. Taraboulos, R. Gabizon
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PRPSC replication, protein folding and misfolding
Neurobiology of Aging, 2000openaire +1 more source
Multidisciplinary standards of care and recent progress in pancreatic ductal adenocarcinoma
Ca-A Cancer Journal for Clinicians, 2020Aaron J Grossberg +2 more
exaly