Results 1 to 10 of about 6,818 (208)

Diagnostic Role and Prognostic Impact of PSAP Immunohistochemistry: A Tissue Microarray Study on 31,358 Cancer Tissues

Diagnostics, 2023
Prostate-specific acid phosphatase (PSAP) is a marker for prostate cancer. To assess the specificity and prognostic impact of PSAP, 14,137 samples from 127 different tumor (sub)types, 17,747 prostate cancers, and 76 different normal tissue types were ...
Claudia Hube-Magg, Till Sebastian Clauditz, Ronald Simon   +2 more
exaly   +4 more sources

Oligodendrocyte prosaposin restores subarachnoid haemorrhage-induced consciousness impairment [PDF]

Experimental and Molecular Medicine
Subarachnoid haemorrhage (SAH) is a life-threatening cerebrovascular event frequently accompanied by consciousness disturbances, yet the underlying mechanisms remain poorly defined.
Haiying Li, Xiang Li, Zhongmou Xu, Chang Cao, Jinxin Lu, Haojie Ding, Lei Bai, Jin Tao, Lu Peng, Jiping Tang, Gang Chen   +10 more
doaj   +2 more sources

A Hypertrophic Stimulus Drives Age-Dependent Transcript Isoform Switching With and Without Differential Gene Expression in Skeletal Muscle. [PDF]

Aging Cell
A combined analysis of short‐read and long‐read RNA‐seq demonstrates reduced isoform switching after an acute hypertrophic stimulus in aged muscle and identifies age‐dependent isoforms that may not be detected with total gene‐level analyses. ABSTRACT Aged skeletal muscle has a reduced ability to adapt to hypertrophic stimuli concomitant with ...
Koopmans PJ, Stokes AL, Nelson CE, Wen Y, Ismaeel A, Murach KA.   +5 more
europepmc   +2 more sources

Secretory full-length human prosaposin (PSAP) inhibits SARS-CoV-2 infection through facilitating the release of S1 subunit of spike protein [PDF]

mBio
The COVID-19 pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has profoundly impacted global public health and the economy.
Chongyang Zhang, Peiwen Ding, Xia Xiao, Bei Wang, He Huang, Qiao Zhang, Lili Ren, Zichun Xiang, Zhuo Zhou, Xiaobo Lei, Jianwei Wang   +10 more
doaj   +2 more sources

Leukodystrophy in Tanzania: A Case Study Highlighting Diagnostic Dilemmas and Clinical Implications [PDF]

Clin Case Rep
ABSTRACT Leukodystrophies are rare inherited neurodegenerative disorders characterized by progressive white matter dysfunction and neurological decline. In low‐resource settings, limited access to advanced neuroimaging, biochemical investigations, and genetic testing often delays diagnosis and complicates differentiation from more common infectious ...
Nkenguye W, Suleman M, Lodhia J.
europepmc   +2 more sources

Accumulation of prosaposin and progranulin around the subfornical organ induces polydipsia in SAP-D-deficient mice [PDF]

Biochemistry and Biophysics Reports
Prosaposin (PSAP), a precursor of saposins, is essential for lysosomal hydrolysis of sphingolipids. It binds with progranulin (PGRN) and transports from the Golgi to lysosomes, where it is processed into saposins.
Harumi Hisaki, Takao Susa, Noriyuki Okudaira, Miho Akimoto, Masayoshi Iizuka, Junko Matsuda, Shunya Uchida, Hiroko Okinaga, Tomoki Okazaki, Mimi Tamamori-Adachi   +9 more
doaj   +2 more sources

Prosaposin orchestrates a TGFβ1-driven paracrine loop between Schwann cells and gastric cancer to accelerate perineural invasion [PDF]

Journal of Experimental & Clinical Cancer Research
Perineural invasion (PNI) is an established adverse prognostic factor in gastric cancer (GC), yet the molecular events initiating this process remain poorly defined.
Shijie Yang, Huan Xi, Miao Yu, LinFan Qi, Lin Ma, ZiJian Wu, Guangming Zhang, Shixun Ma, Hui Cai   +8 more
doaj   +2 more sources

The transmembrane IL-15 isoform expressed on human melanoma cells triggers modulatory effects on tumor progression upon stimulation with the soluble IL-15Rα chain [PDF]

Frontiers in Immunology
Interleukin-15 (IL-15) is expressed in various cancers, including melanoma, where it exists in distinct membrane-associated isoforms. Primary melanoma cells predominantly express the non-cleavable transmembrane form (tmbIL-15), while metastatic cells ...
Sergio Forcelloni, Julien Giron-Michel, Piero Del Boccio, Piero Del Boccio, Maria Concetta Cufaro, Maria Concetta Cufaro, Alice Di Sebastiano, Alice Di Sebastiano, Francesca Romana Mariotti, Cecilia Ciancaglini, Salem Chouaib, Salem Chouaib, Mael Padelli, Mael Padelli, Simone Vespa, Giang Dang Mac, Stefan Ebert, Stéphanie Buart, Enrico Maggi, Lorenzo Moretta, Paola Vacca, Nicola Tumino, Linda Quatrini, Ignazio Caruana, Bruno Azzarone, Silvia Santopolo   +25 more
doaj   +2 more sources

Clinical Performance of a Smartphone-Based Sound Amplification Device Versus a Personal Sound Amplification Product in Elders with Mild-to-Moderate Hearing Loss: A Prospective Cohort Study [PDF]

Medicina
Background and Objectives: To evaluate the clinical performance of a smartphone-based sound amplification device (SBSAD) compared to a conventional personal sound amplification product (PSAP) in older adults with mild-to-moderate sensorineural hearing ...
Cheng-Jung Wu, Sheng-Yu Wu, Cheng-Yu Tsai, Arnab Majumdar, Jeffrey Yang, Jinn-Moon Yang, Lok-Yee Joyce Li   +6 more
doaj   +2 more sources

ACE‐mediated Glycosylation Stabilizes PSAP To Promote GPR37‐dependent Macrophage‐Nucleus Pulposus Cells Crosstalk and TGFβ Signaling in Alleviating Intervertebral Disc Degeneration [PDF]

Advanced Science
Intervertebral disc degeneration (IDD) represents a complex pathological process involving impaired cellular homeostasis and extracellular matrix dysregulation.
Youfeng Guo, Feng Wang, Bijun Wang, Yu Zhou, Chao Wang, Tao Hu, Desheng Wu   +6 more
doaj   +2 more sources