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Chemical Modification of Pseudomonas aeruginosa Exotoxin A
1978The author would like to thank Dr. Stephen H. Leppla for his suggestions during the course of the work described in this thesis, and for the independence assigned the author throughout the past three years under his employment. The author thanks Ms. Rebecca B. Dorland for her assistance with the binding assay, for her typing of this thesis, and for her
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Toxoid from Exotoxin A of Pseudomonas aeruginosa: Preparation and Characterization
Journal of Infectious Diseases, 1982Toxoid was prepared by treating exotoxin A of Pseudomonas aeruginosa with formalin. Coincubation of exotoxin A for two to four weeks at 37 degrees C with 0.5% formalin and 10(-3) M lysine followed by one to two weeks of storage in the absence of these reagents reduced cytotoxicity, preserved antigenicity, and minimized subsequent reversion of the ...
M, Pollack, R K, Prescott
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Effect of Pseudomonas aeruginosa Exotoxin A on Inner Ear Function
Acta Oto-Laryngologica, 1997Electrophysiological changes were studied in the albino rat following instillation of Pseudomonas aeruginosa exotoxin A into the middle ear cavity through the tympanic membrane. Hearing threshold was measured by a burst-elicited, frequency-specific auditory brainstem response (ABR) technique prior to exposure, then 24 and 48 h, 5 days, 2 and 4 weeks ...
M, Stenqvist, M, Anniko, A, Pettersson
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Susceptibility of Mammalian Cells to Pseudomonas Exotoxin A
1993Bacterial toxins exhibit a great diversity in host range, mechanisms of action, and routes by which they reach their targets. In spite of these differences, many of the bacterial toxins, as well as several well-characterized plant toxins, share several common features.
Randal E. Morris, Catharine B. Saelinger
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Construction of immunotoxins using Pseudomonas exotoxin A.
Methods in enzymology, 1988The above methodology has been used to prepare a variety of PE-immunotoxins. These reagents are potent cytotoxic agents for cells in culture that bind the appropriate antibody and nontoxic when cells do not bind the antibody. PE-immunotoxins can be used to select for mutant cultured cells which lack the target of the antibody (see chapter by Gottesman [
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The Role of Exotoxin A in Pseudomonas Disease and Immunity
Clinical Infectious Diseases, 1983Exotoxin A is an extracellular enzyme that is produced by most clinical strains of Pseudomonas aeruginosa. It is a single-chain polypeptide (molecular weight, 71,000) with A and B fragments that mediate enzymatic and cell-binding functions, respectively.
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Intracellular Trafficking of Pseudomonas Exotoxin A
2015C B, Saelinger, R E, Morris
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[12] Construction of immunotoxins using Pseudomonas exotoxin A
1987Abstract The above methodology has been used to prepare a variety of PE-immunotoxins. These reagents are potent cytotoxic agents for cells in culture that bind the appropriate antibody 6–9 and nontoxic when cells do not bind the antibody. 7,9 PE-immunotoxins can be used to select for mutant cultured cells which lack the target of the antibody (see ...
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Diphtheria Toxin and Exotoxin A from Pseudomonas aeruginosa
1979A marked resurgence of interest in bacterial protein toxins has occurred in recent years, after a long period of relative neglect. Many of the classical toxins have been studied in greater depth, and new toxins have been discovered as well. As a result of the expanded interest and efforts there now exists a substantial and rapidly growing body of ...
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