Results 101 to 110 of about 8,117 (224)

Characterisation of Pseudorabies Virus and Its Mutants [PDF]

, 1999
A plaque-purified pseudorabies virus (PrV-mAIP) was established from a field isolate. Following exposure to bromodeoxyuridine (BUdR) and iododeoxyuridine (IUdR), six drug resistant mutants namely PrV-BUdRI, PrVBUdR7, PrV-BUdRlO, PrV-IUdR5, PrV-IUdR9 and ...
Allaudin, Zeenathul Nazariah
core  

Reduced virulence of a pseudorabies virus isolate from wild boar origin in domestic pigs correlates with hampered visceral spread and age-dependent reduced neuroinvasive capacity [PDF]

, 2017
Morbidity and mortality associated with pseudorabies virus (PRV) infection are dependent on the age of the pig and the virulence of the strain. PRV strains circulating in wild boar are considered to be low virulent, but no mechanistic explanation for ...
Cay, Ann Brigitte, De Regge, Nick, Favoreel, Herman, Redant, Valerie, Verpoest, Sara   +4 more
core   +2 more sources

Mesenchymal Stromal Cells Play an Analgesic Role Through a Npy2r Sensory Neuron‐Mediated Lung‐to‐Brain Axis

Advanced Science, Volume 12, Issue 43, November 20, 2025.
Mesenchymal stromal cells (MSC) are considered a promising alternative for neuropathic pain (NP) treatment, but underlying mechanisms remain elusive. Huang et al. illustrate that a Npy2r sensory neuron‐related lung–brain axis contributes to MSC analgesia.
Jing Huang, Taihe Zhou, Yueming Sun, Yuanchen Ma, Yiwen Deng, Keyu Chen, Ruijie Li, Yuan Qiu, Tao Wang, Xiaoyong Chen, Li Huang, Lu Zhu, Xueyi Tu, Ying Wang, Zheming Liu, Rouchen Lin, Yunli Tong, Yuantao Li, Heshe Li, Lin Nie, Rui Fang, Jianqi Feng, Xuhong Wei, Xia Feng, Andy Peng Xiang, Xiaoran Zhang   +25 more
wiley   +1 more source

A trypsin-like serine protease is involved in pseudorabies virus invasion through the basement membrane barrier of porcine nasal respiratory mucosa [PDF]

, 2011
Several alphaherpesviruses breach the basement membrane during mucosal invasion. In the present study, the role of proteases in this process was examined.
Glorieux, Sarah, Favoreel, Herman, Steukers, Lennert, Vandekerckhove, Annelies, Nauwynck, Hans   +4 more
core   +2 more sources

Parasubthalamic Glutamatergic Neurons Coordinate Cardiovascular Homeostasis and Locomotion in Mice

Advanced Science, Volume 12, Issue 40, October 27, 2025.
PSTNVglut2 neurons function as a new central baroreflex hub via projections to the NTS, modulating parasympathetic cardiac output to maintain cardiovascular homeostasis while synchronously regulating locomotion. Blood pressure fluctuations negatively correlate with locomotor performance.
Ming‐Xuan Lu, Jin‐Yin Huang, Xing‐Zhe Xu, Ji‐Yu Sun, Dan‐Ni Zou, Jia‐Yao Zhang, Chen Chi, Qi Zhang, Wei‐Cai Liu   +8 more
wiley   +1 more source

Activation of Spinal Astrocyte α2A Adrenoceptors Protects Against Sepsis‐Induced Heart Injury Through Inhibition of GABAergic Neuronal Necroptosis

Advanced Science, Volume 12, Issue 39, October 20, 2025.
The study in this paper found that activating the α2A receptors of astrocytes in the thoracic spinal cord can reduce the release of inflammatory factors, thereby decreasing the necroptosis of GABAergic neurons and consequently alleviating myocardial injury caused by sepsis.
Ruilin He, Bin Wu, Liuhu Han, Mingde Li, Wenli Guo, Jiajing Fu, Bin Mei, Eric R. Gross, Xuesheng Liu, Yao Lu   +9 more
wiley   +1 more source

A novel non-mineral oil-based adjuvant. II. Efficacy of a synthetic sulfolipopolysaccharide in a squalane-in-water emulsion in pigs [PDF]

, 1994
The adjuvanticity of a sulfolipopolysaccharide (SLP) incorporated into a squalane-in-water emulsion (SLP/S/W) was compared with that of a mineral oil-in-water (O/W) adjuvant currently used in commercial porcine vaccines.
Dazelle, T. (T.), Groenveld, B. (B.), Hilgers, L.A.Th. (L. A Th), Luitjens, A. (A.), Platenburg, P.L.I. (P. L I), Weststrate, J.T.M.   +5 more
core   +1 more source

Development of a Ready‐To‐Use Bioluminescence Immunosensor for the One‐Step Sensitive Detection of Antibodies Against African Swine Fever Virus

Microbial Biotechnology, Volume 18, Issue 10, October 2025.
A ready‐to‐use bioluminescence immunosensor for rapid, one‐step detection of ASFV antibodies, offering high specificity, high sensitivity, and ease of use, with promising applications for point‐of‐care diagnostics. ABSTRACT Rapid and reliable analytical techniques play important roles in various research fields and are particularly crucial for ...
Zhonghui Zhang, Xuesai Li, Qingli Niu, Jinming Wang, Yanghe Liu, Dossêh Jean Apôtre Afayibo, Wenting Chen, Songlin Yang, Hong Yin, Guiquan Guan, Jifei Yang   +10 more
wiley   +1 more source

Pseudorabies virus hijacks the Rab6 protein to promote viral assembly and egress

Veterinary Research
Pseudorabies virus (PRV) is recognized as the aetiological agent responsible for Aujeszky’s disease, or pseudorabies, in swine populations. Rab6, a member of the small GTPase family, is implicated in various membrane trafficking processes, particularly ...
Dong-Ge Liang, Yu-Kun Guo, Shi-Bo Zhao, Guo-Yu Yang, Ying-Qian Han, Bei-Bei Chu, Sheng-Li Ming   +6 more
doaj   +1 more source

DNA aptamers targeting glycoprotein D enable specific detection of pseudorabies virus (PRV)

Animal Diseases
Abstract Pseudorabies virus (PRV, SuidAlphaherpesvirus 1) causes substantial economic losses in swine production. Here, we report the development of DNA aptamers targeting the PRV glycoprotein D (gD) through an optimized SELEX protocol. After 15 selection cycles, Apt-gD-2 demonstrated nanomolar affinity (Kd = 6.107 ± 0.476 nM) and high ...
Zhihao Wang, Yan Qiao, Jiafu Zhao, Xiaotian Chang, Heshui Zhu, Chao Zhang   +5 more
openaire   +2 more sources