Results 171 to 180 of about 1,806,143 (218)

RNA pseudouridine modification in plants.

Journal of Experimental Botany, 2023
Abstract Pseudouridine is one of the well-known chemical modifications in various RNA species. Current advances to detect pseudouridine show that the pseudouridine landscape is dynamic and affects multiple cellular processes. Although our understanding of this post-transcriptional modification mainly depends on yeast and human models ...
Niu Yanli, Lingyun Liu
exaly   +3 more sources

Semi-enzymatic synthesis of pseudouridine

Bioorganic and Medicinal Chemistry Letters, 2021
Modifications of RNA molecules have a significant effect on their structure and function. One of the most common modifications is the isomerization from uridine to pseudouridine. Despite its prevalence in natural RNA sequences, organic synthesis of pseudouridine has been challenging because of the stereochemistry requirement and the sensitivity of ...
Elliot Clerc, Andrew T Riley, Mina Sumita   +2 more
exaly   +3 more sources

Pseudouridine Modifications in Transfer RNA and tRNA Pseudouridine Synthases

Journal of Molecular Biology
Among the various modifications found in transfer RNAs, pseudouridine occurs the most frequently in all organisms and is also found in other RNA species including ribosomal, messenger, small nuclear, small nucleolar, and transfer-messenger RNA. Since the first gene encoding a tRNA pseudouridine synthase (truA) was discovered in 1978, many pseudouridine
Chie Tomikawa
exaly   +3 more sources

X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold [PDF]

FEBS Letters, 2004
Pseudouridine synthases catalyse the isomerisation of uridine to pseudouridine in structural RNA. The pseudouridine synthase TruD, that modifies U13 in tRNA, belongs to a recently identified and large family of pseudouridine synthases present in all ...
B Martin Hallberg, Pär Nordlund, Ulrika B Ericsson   +2 more
exaly   +2 more sources

Molecular modeling studies of pseudouridine isoxazolidinyl nucleoside analogues as potential inhibitors of the pseudouridine 5ʹ-monophosphate glycosidase

Chemical Biology and Drug Design, 2018
In this paper, we investigated the hypothesis that pseudouridine isoxazolidinyl nucleoside analogues could act as potential inhibitors of the pseudouridine 5ʹ-monophosphate glycosidase. This purpose was pursued using molecular modeling and in silico ADME-
Antonio Rescifina, Maria Dichiara, Giuseppe Floresta   +2 more
exaly   +2 more sources

The Biochemistry of Pseudouridine

1966
Publisher Summary The chapter discusses the biochemistry of pseudouridine. It also discusses in a critical, selective, and occasionally speculative fashion, the special enzymological properties, the mode of biosynthesis, and the biological role of pseudouridine.
E, Goldwasser, R L, Heinrikson
openaire   +2 more sources

Preparation of 14C-pseudouridine

Analytical Biochemistry, 1968
Abstract A method is deseribed by which 14 C-pseudouridine may be isolated from the culture medium of A. tumefaciens grown on a synthetic medium containing glucose and 2- 14 C-uracil. The method is simple and relatively rapid, and yields the natural form of pseudouridine with a specific activity equivalent to that of the uracil used.
M, Jacobson, C, Hedgcoth
openaire   +2 more sources

A synthesis of pseudouridine

Journal of the Chemical Society, Perkin Transactions 1, 1981
2,3,5-Tri-O-benzylribose and 2,4-di-t-butoxy-5-lithiopyrimidine (from the 5-bromo-compound and butyllithium) in THF at –78 °C give 5-(2,3,5-tri-O-benzyl-D-altro-pentahydroxypentyl)-2,4-di-t-butoxypyrimidine and its D-allo-epimer (ratio 5:2), which cyclise stereospecifically in ethanolic hydrochloric acid to 5-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl ...
Daniel M. Brown, Richard C. Ogden
openaire   +1 more source

Pseudouridine: Biosynthesis by Streptoverticillicum ladakanus

Biochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973
Abstract Recent studies have shown that pseudouridine in tRNA is formed by rearrangement of UMP residues. In the studies reported, information was not provided to clarify if the rearrangement of UMP residues to pseudouridine 5′-monophosphate was intramolecular or intermolecular.
T, Uematsu, R J, Suhadolnik
openaire   +2 more sources

The Chemistry of Pseudouridine

1966
Publisher Summary This chapter discusses the chemistry of pseudouridine, leaving the biological properties for a companion review. It points out the unique chemical features of pseudouridine and an attempt to rationalize them in terms of modern organic chemistry.
openaire   +2 more sources