Results 181 to 190 of about 1,806,143 (218)

Predicting Pseudouridine Sites with Porpoise

2023
Pseudouridine is a ubiquitous RNA modification and plays a crucial role in many biological processes. However, it remains a challenging task to identify pseudouridine sites using expensive and time-consuming experimental research. To this end, we present Porpoise, a computational approach to identify pseudouridine sites from RNA sequence data. Porpoise
Xudong, Guo, Fuyi, Li, Jiangning, Song
openaire   +2 more sources

Mapping Pseudouridines in RNA Molecules

Methods, 2001
Pseudouridine is present in ribosomal RNA, transfer RNA, tmRNA, and small nuclear and nucleolar RNAs. All are structured molecules. Pseudouridine is made by enzyme-catalyzed isomerization of specifically selected U residues after the polynucleotide chain is made. No energy input is required.
J, Ofengand, M, Del Campo, Y, Kaya
openaire   +2 more sources

The pseudouridine residues of ribosomal RNA

Biochemistry and Cell Biology, 1995
Pseudouridine (Ψ), the most common single modified nucleoside in ribosomal RNA, has been positioned in the small subunit (SSU) and large subunit (LSU) RNAs of a number of representative species. Most of the information has been obtained by application of a rapid primed reverse transcriptase sequencing technique.
J, Ofengand, A, Bakin, J, Wrzesinski, K, Nurse, B G, Lane   +4 more
openaire   +2 more sources

Pseudouridine: A Biochemical Marker for Cancer

1984
Although some progress has been made in clarifying the molecular basis underlying neoplastic transformation, antineoplastic treatment is still based on the effort toward the removal of all neoplastic cells. In this respect, the most important requirement for the effectiveness of treatment is the precocious diagnosis, possibly in the preclinical period.
CIMINO, FILIBERTO, RUSSO, TOMMASO, COLONNA, ALFREDO, SALVATORE, FRANCESCO   +3 more
openaire   +2 more sources

Structure and conformation of pseudouridine analogs

Biochemistry, 1981
The structural and conformational features of the "anomeric" DL-trans- and DL-cis-5-(3-hydroxytetrahydrofuran-2-yl)uracils (3a, 4a) and five similar analogues were studied in order to determine their applicability as models of beta- and alpha-pseudouridine.
R L, Lipnick, J D, Fissekis, J P, O'Brien   +2 more
openaire   +2 more sources

attempted prebiotic synthesis of pseudouridine

Origins of life and evolution of the biosphere, 1997
Pseudouridine is a modified base found in all tRNA and rRNA. Hence, it is reasonable to think that pseudouridine was important in the early evolution, if not the origin, of life. Since uracil reacts rapidly with formaldehyde and other aldehydes at the C-5 position, it is plausible that pseudouridine could be synthesized in a similar way by the reaction
openaire   +2 more sources

Detection and Quantification of Pseudouridine in RNA

2018
Pseudouridylation is the most abundant of all RNA modifications. Pseudouridylation is dynamic and widespread among many different types of RNAs in living organisms, thus drawing a lot of recent interest from the RNA and epigenetics communities. To successfully carry out an investigation into RNA pseudouridylation, it is desirable to have a convenient ...
Hironori, Adachi, Meemanage D, DeZoysa, Yi-Tao, Yu   +2 more
openaire   +2 more sources

Cyclo-pseudouridine and the Configuration of Pseudouridine

Biochemistry, 1962
A M, MICHELSON, W E, COHN
openaire   +2 more sources

Conformation of pseudouridine and pseudouridine 5'-phosphate. Ultraviolet and nuclear magnetic resonance study

Biochemistry, 1970
O-Isopropylidenepseudouridine 5 '-acetate has been synthesized and its ultraviolet spectrum shown to be the same as that of a 5'-unsubstituted pseudouridine. Con- trary to earlier proposals it is concluded, that the presence of a 5'-hydroxyl is without influence on the ultraviolet spectrum and distribution of tautomeric monoanions in pseudouridine ...
openaire   +2 more sources

Pseudouridine

Acta Crystallographica Section C Crystal Structure Communications, 1997
A. Hempel, B. G. Lane, N. Camerman
openaire   +1 more source