Interactions of transfer RNA pseudouridine synthases with RNAs substituted with fluorouracil
Nucleic Acids Research, 1991 We have previously purified and characterized two different S. cerevisiae enzymes that produce pseudouridine specifically in nucleotide positions 13 and 55, respectively, in their tRNA substrates. The interactions of these enzymes with fluorinated tRNAs have now been studied.
openaire +3 more sources
Pseudouridine-Free Escherichia coli Ribosomes
, 2018 Pseudouridine (Ψ) is present at conserved, functionally important regions in the ribosomal RNAs (rRNAs) from all three domains of life. Little, however, is known about the functions of Ψ modifications in bacterial ribosomes.
Margus Leppik +2 more
core +1 more source
Genome-Wide Identification and Expression Analysis of Pseudouridine Synthase Family in Arabidopsis and Maize. [PDF]
Int J Mol Sci, 2022 Xie Y, Gu Y, Shi G, He J, Hu W, Zhang Z.
europepmc +1 more source
HSP90/PUS7/THUMPD1 promotes metastasis and cisplatin resistance in gastric cancer cells
Scientific ReportsThe metastasis and chemotherapy resistance of gastric cancer significantly contribute to treatment failure and mortality. Based on previous studies, we hypothesized that Heat Shock Protein 90 (HSP90) interacts with and upregulates Pseudouridine Synthase ...
Ziwei Ye +8 more
doaj +1 more source
Human TRUB1 is a highly conserved pseudouridine synthase responsible for the formation of Ψ55 in mitochondrial tRNAAsn, tRNAGln, tRNAGlu and tRNAPro. [PDF]
Nucleic Acids Res, 2022 Jia Z +12 more
europepmc +1 more source
Loss of Pseudouridine Synthases in the RluA Family Causes Hypersensitive Nociception in Drosophila
G3: Genes, Genomes, Genetics, 2020 Wan Song +2 more
doaj +1 more source
Dyskerin: an essential pseudouridine synthase with multifaceted roles in ribosome biogenesis, splicing, and telomere maintenance. [PDF]
RNA, 2021 Garus A, Autexier C.
europepmc +1 more source
Cloning and characterization of Arabidopsis thaliana AtNAP57 - a homologue of yeast pseudouridine synthase Cbf5p. [PDF]
, 2002 Rat Nap57 and its yeast homologue Cbf5p are pseudouridine synthases involved in rRNA biogenesis, localized in the nucleolus. These proteins, together with H/ACA class of snoRNAs compose snoRNP particles, in which snoRNA guides the synthase to direct site-
Kmieciak, Maciej +3 more
core
The Trypanosoma brucei sphingolipid synthase, an essential enzyme and a drug target [PDF]
, 2009 Sphingolipids are important structural components of eukaryotic membranes, in addition they and their precursors are involved in signal transduction processes.
Pan, Ssu-Ying
core
BMC Medical GenomicsBackground Myopathy, lactic acidosis and inherited sideroblastic anemia (MLASA) are a group of rare intriguing disorders with wider pathophysiological implications.
Shyam S. Kothari +5 more
doaj +1 more source