Results 71 to 80 of about 431,100 (179)

The Growth And Metabolic Effects Of Pseudouridine Synthase Gene Deletion On Escherichia Coli Strain Bl21 [PDF]

, 2015
During the process of ribosome assembly and maturation, the rRNA is heavily modified. The process of modification is ubiquitous throughout all kingdoms of life and includes cleavage by RNases, methylation and pseudouridylation of RNA species ...
Burnette, Lisa Marie
core   +1 more source

Survey and Validation of tRNA Modifications and Their Corresponding Genes in Bacillus subtilis sp Subtilis Strain 168

Biomolecules, 2020
Extensive knowledge of both the nature and position of tRNA modifications in all cellular tRNAs has been limited to two bacteria, Escherichia coli and Mycoplasma capricolum. Bacillus subtilis sp subtilis strain 168 is the model Gram-positive bacteria and
Valérie de Crécy-Lagard, Robert L. Ross, Marshall Jaroch, Virginie Marchand, Christina Eisenhart, Damien Brégeon, Yuri Motorin, Patrick A. Limbach   +7 more
doaj   +1 more source

Gene Expression-Based Predication of RNA Pseudouridine Modification in Tumor Microenvironment and Prognosis of Glioma Patients

Frontiers in Cell and Developmental Biology, 2022
Aberrant expression of methyltransferases and demethylases may augment tumor initiation, proliferation and metastasis through RNA modification, such as m6A and m5C. However, activity of pseudouridine (Ψ) modification of RNA remains unknown in glioma, the
Lin-jian Wang, Lin-jian Wang, Peipei Lv, Yongli Lou, Jianping Ye, Jianping Ye   +5 more
doaj   +1 more source

N‐Terminal Variant p.Ala2Val in X‐Linked Dyskeratosis Congenita Gene (DKC1) Disrupts Its Post‐Translational Modification and Nucleolar Localization

Molecular Genetics &Genomic Medicine, Volume 14, Issue 8, August 2026.
Major symptoms of dyskeratosis congenita. Predicted nuclear localization site at N‐terminus of DKC1 protein. Comparison of nuclear localization for DKC1 showing normal localization for wild‐type versus disruption of localization for p.Ala2Val. ABSTRACT Background Dyskeratosis congenita (DKC) is typically characterized by the triad of abnormal cutaneous
Taimoor I. Sheikh, John B. Vincent
wiley   +1 more source

PUS1 May Be a Potential Prognostic Biomarker and Therapeutic Target for Hepatocellular Carcinoma

Pharmacogenomics and Personalized Medicine, 2023
Chenlu Lan,1,2,* Xinlei Huang,1,2,* Xiwen Liao,1,2 Xin Zhou,1,2 Kai Peng,1,2 Yongguang Wei,1,2 Chuangye Han,1,2 Tao Peng,1,2 Jianyao Wang,3 Guangzhi Zhu1,2 1Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical ...
Lan C, Huang X, Liao X, Zhou X, Peng K, Wei Y, Han C, Peng T, Wang J, Zhu G   +9 more
doaj  

RNA Modifications in Tumor Microenvironment: A New Dimension for Cancer Treatment

MedComm, Volume 7, Issue 7, July 2026.
Tumor initiation and progression depend on a supportive and highly heterogeneous tumor microenvironment (TME). RNA modifications regulate signaling pathways and cytokine networks that shape TME dynamics, facilitating interactions between cancer cells and noncancerous stromal cells, and ultimately promoting immune evasion and tumor progression ...
Qiwen Li, Yating Sun, Shuibin Lin, Quan Yuan   +3 more
wiley   +1 more source

PUS10-induced tRNA fragmentation impacts retrotransposon-driven inflammation

Cell Reports
Summary: Pseudouridine synthases (PUSs) catalyze the isomerization of uridine (U)-to-pseudouridine (Ψ) and have emerging roles in development and disease. How PUSs adapt gene expression under stress remains mostly unexplored.
Magdalena Madej, Phuong Cao Thi Ngoc, Sowndarya Muthukumar, Anna Konturek-Cieśla, Silvia Tucciarone, Alexandre Germanos, Christian Ashworth, Knut Kotarsky, Sudip Ghosh, Zhimeng Fan, Helena Fritz, Izei Pascual-Gonzalez, Alain Huerta, Nicola Guzzi, Anita Colazzo, Giulia Beneventi, Hang-Mao Lee, Maciej Cieśla, Christopher Douse, Hiroki Kato, Vinay Swaminathan, William W. Agace, Ainara Castellanos-Rubio, Paolo Salomoni, David Bryder, Cristian Bellodi   +25 more
doaj   +1 more source

Pentatricopeptide repeat proteins in crops: Advances in functional mechanisms and breeding applications

Journal of Integrative Plant Biology, Volume 68, Issue 7, Page 1973-2000, July 2026.
Pentatricopeptide repeat proteins coordinate nucleus‐organelle communication by modulating RNA metabolism within chloroplasts and mitochondria. This review highlights how they control critical processes like photosynthesis, seed development, fertility restoration, and stress survival in crops, and explores their potential as programmable tools for RNA ...
Mingming Wu, Maohong Cai, Rongrong Zhai, Jing Ye, Guofu Zhu, Faming Yu, Shenghai Ye, Xiaoming Zhang   +7 more
wiley   +1 more source

Transfer RNA pseudouridine synthases in Saccharomyces cerevisiae.

Journal of Biological Chemistry, 1990
A transfer RNA lacking modified nucleosides was produced by transcription in vitro of a cloned gene that encodes a Saccharomyces cerevisiae glycine tRNA. At least three different uridines (in nucleotide positions 13, 32, and 55) of this transcript tRNA are modified to pseudouridine by an extract of S. cerevisiae. Variants of the RNA substrate were also
T, Samuelsson, M, Olsson
openaire   +2 more sources

RluD, a highly conserved pseudouridine synthase, modifies 50S subunits more specifically and efficiently than free 23S rRNA

, 2007
Pseudouridine modifications in helix 69 (H69) of 23S ribosomal RNA are highly conserved among all organisms. H69 associates with helix 44 of 16S rRNA to form bridge B2a, which plays a vital role in bridging the two ribosomal subunits and stabilizing the ...
Vaidyanathan, Pavanapuresan P, Deutscher, Murray P, Malhotra, Arun   +2 more
core   +1 more source