Results 1 to 10 of about 18,448 (248)

Anti-inflammatory activity of psoralen in human periodontal ligament cells via estrogen receptor signaling pathway

Scientific Reports, 2021
Psoralen is one of the most effective ingredients extracted from the Chinese herb, Psoralea corylifolia L. Studies have found that psoralen has anti-inflammatory and estrogen-like effects; however, little research has been conducted to elucidate the ...
Huxiao Li, Jianrong Xu, Xiaotian Li, Yi Hu, Yue Liao, Wei Zhou, Zhongchen Song   +6 more
doaj   +2 more sources

Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2

Stem Cell Research & Therapy, 2022
Background Repairing radiation-induced bone injuries remains a significant challenge in the clinic, and few effective medicines are currently available.
Bo-Feng Yin, Zhi-Ling Li, Zi-Qiao Yan, Zheng Guo, Jia-Wu Liang, Qian Wang, Zhi-Dong Zhao, Pei-Lin Li, Rui-Cong Hao, Meng-Yue Han, Xiao-Tong Li, Ning Mao, Li Ding, Da-Fu Chen, Yue Gao, Heng Zhu   +15 more
doaj   +2 more sources

Psoralen Induces Developmental Toxicity in Zebrafish Embryos/Larvae Through Oxidative Stress, Apoptosis, and Energy Metabolism Disorder

Frontiers in Pharmacology, 2018
Psoralen toxicity is an issue of wide concern. However, an assay for psoralen-induced developmental toxicity has not been reported to date. Moreover, the underlying mechanism of psoralen-induced developmental toxicity is unclear.
Qing Xia, Lingying Wei, Yun Zhang, Haotian Kong, Yongping Shi, Yongping Shi, Xue Wang, Xiqiang Chen, Liwen Han, Kechun Liu   +9 more
doaj   +2 more sources

Development and functional evaluation of a psoralen-conjugated nucleoside mimic for triplex-forming oligonucleotides [PDF]

Communications Chemistry
Psoralen-conjugated triplex-forming oligonucleotides (Ps-TFOs) have been employed for the photodynamic regulation of gene expression by the photo-cross-linking of psoralen with the target DNA.
Yu Mikame, Haruki Toyama, Chikara Dohno, Takehiko Wada, Asako Yamayoshi   +4 more
doaj   +2 more sources

X-Ray Psoralen Activated Cancer Therapy (X-PACT). [PDF]

PLoS ONE, 2016
This work investigates X-PACT (X-ray Psoralen Activated Cancer Therapy): a new approach for the treatment of solid cancer. X-PACT utilizes psoralen, a potent anti-cancer therapeutic with current application to proliferative disease and extracorporeal ...
Mark Oldham, Paul Yoon, Zak Fathi, Wayne F Beyer, Justus Adamson, Leihua Liu, David Alcorta, Wenle Xia, Takuya Osada, Congxiao Liu, Xiao Y Yang, Rebecca D Dodd, James E Herndon, Boyu Meng, David G Kirsch, H Kim Lyerly, Mark W Dewhirst, Peter Fecci, Harold Walder, Neil L Spector   +19 more
doaj   +2 more sources

The effects of CYP2B6 inactivators on the metabolism of ciprofol. [PDF]

PLoS ONE
Ciprofol is a novel short-acting intravenous anaesthetic developed in China that is mainly metabolized by cytochrome P450 2B6 (CYP2B6) and uridine diphosphate glucuronosyltransferase 1A9 (UGT1A9).
Ming Lu, Xiaorui Zhang, Wenli Li, Xiangchen Li, Shan Li, Xiaoyu Yin, Zhiqing Zhang   +6 more
doaj   +2 more sources

Psoralen Suppresses Lipid Deposition by Alleviating Insulin Resistance and Promoting Autophagy in Oleate-Induced L02 Cells

Cells, 2022
Non-alcoholic fatty liver disease (NAFLD) held a high global prevalence in recent decades. Hepatic lipid deposition is the major characteristic of NAFLD. We aim to explore the mechanisms of psoralen on lipid deposition in NAFLD.
Yuhao Wang, Yonglun Wang, Fang Li, Jie Zou, Xiaoqian Li, Mengxia Xu, Daojiang Yu, Yijia Ma, Wei Huang, Xiaodong Sun, Yuanyuan Zhang   +10 more
doaj   +1 more source

Therapeutic effect of psoralen on muscle atrophy induced by tumor necrosis factor-α [PDF]

Iranian Journal of Basic Medical Sciences, 2020
Objective(s): To observe and determine the effect and mechanism of psoralen on tumor necrosis factor-α (TNF-α)-induced muscle atrophy.Materials and Methods: Three sets of C2C12 cells, including blank control, TNF-α (10 or 20 ng/ml) treatment and a TNF-α (
Xin-Feng Lin, Qi-Long Jiang, Zhi-Long Peng, Yi-Le Ning, Yuan-Yuan Luo, Fu Zhao, Xian Peng, Wei-Tao Chen   +7 more
doaj   +1 more source

Psoralen alleviates high glucose-induced HK-2 cell injury by inhibition of Smad 2 signaling via upregulation of microRNA 874

BMC Pharmacology and Toxicology, 2020
Background Diabetic nephropathy (DN) causes the vast proportion of excess mortality for patients with diabetes. Novel therapeutic approaches slowing down its incidence is still lacking. Psoralen is the major active ingredient of Psoralea corylifolia Linn.
Yongtao Lin, Lili Zhong, Hailun Li, Yong Xu, Xiang Li, Donghui Zheng   +5 more
doaj   +1 more source

Psoralen Promotes Proliferation, Migration, and Invasion of Human Extravillous Trophoblast Derived HTR-8/Svneo Cells in vitro by NF-κB Pathway

Frontiers in Pharmacology, 2022
Recurrent spontaneous abortion (RSA) is a kind of pathological pregnancy, and abnormal function of trophoblast cells may be related to a variety of pregnancy complications including RSA.
Dan Qi, Jingyuan Lu, Ziyi Fu, Shanshan Lv, Lili Hou   +4 more
doaj   +1 more source