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Circulating Metabolomic Signature in Generalized Pustular Psoriasis Blunts Monocyte Hyperinflammation by Triggering Amino Acid Response

open access: yesFrontiers in Immunology, 2021
Generalized pustular psoriasis (GPP), the most grievous variant of psoriasis, is featured by dysregulated systemic inflammatory response. The cellular and molecular basis of GPP is poorly understood.
Ning Yu   +7 more
doaj   +1 more source

JAK3 as an emerging target for topical treatment of inflammatory skin diseases [PDF]

open access: yes, 2016
The recent interest and elucidation of the JAK/STAT signaling pathway created new targets for the treatment of inflammatory skin diseases (ISDs). JAK inhibitors in oral and topical formulations have shown beneficial results in psoriasis and alopecia ...
Alves de Medeiros, Ana   +5 more
core   +8 more sources

Adjunctive Use of Calcipotriene/Betamethasone Dipropionate Foam in a Real-World Setting Curtails the Cost of Biologics Without Reducing Efficacy in Psoriasis

open access: yesDermatology and Therapy, 2020
Introduction Although the efficacy of monotherapy with biologics for psoriasis is well established, many patients fail to achieve complete plaque clearance from their initial biologic treatment alone.
Jerry Bagel   +3 more
doaj   +1 more source

Association of Psoriasis With Anxiety and Depression: A Case–Control Study in Chinese Patients

open access: yesFrontiers in Medicine, 2021
Background: Patients with psoriasis are prone to suffer from anxiety and depression during their lifetime. This study aimed to investigate the association of psoriasis with anxiety and depression in Chinese patients.Methods: A case-control study in ...
Danrong Jing   +22 more
doaj   +1 more source

Novel Coronavirus Disease (COVID-19) and Biologic Therapy in Psoriasis: Infection Risk and Patient Counseling in Uncertain Times

open access: yesDermatology and Therapy, 2020
With the emergence of the novel coronavirus disease (COVID-19) viral pandemic, there is uncertainty whether biologic agents for psoriasis may place patients at a higher risk for infection or more severe disease course.
Nicholas D. Brownstone   +6 more
doaj   +1 more source

Molecular and functional changes in neutrophilic granulocytes induced by nicotine: a systematic review and critical evaluation

open access: yesFrontiers in Immunology, 2023
BackgroundOver 1.1 billion people smoke worldwide. The alkaloid nicotine is a prominent and addictive component of tobacco. In addition to tumors and cardiovascular disorders, tobacco consumption is associated with a variety of chronic-inflammatory ...
Theresa-Charlotte Brembach   +6 more
doaj   +1 more source

The role of 39 psoriasis risk variants on age of psoriasis onset. [PDF]

open access: yes, 2013
Recent genome-wide association studies (GWAS) have identified multiple genetic risk factors for psoriasis, but data on their association with age of onset have been marginally explored.
Butler, Daniel   +12 more
core   +2 more sources

Factors Influencing Sleep Difficulty and Sleep Quantity in the Citizen Pscientist Psoriatic Cohort

open access: yesDermatology and Therapy, 2019
Introduction Sleep is essential for overall health and well-being, yet more than one-third of adults report inadequate sleep. The prevalence is higher among people with psoriasis, with up to 85.4% of the psoriatic population reporting sleep disruption ...
Mary Patricia Smith   +20 more
doaj   +1 more source

Novel Coronavirus Disease (COVID-19) and Biologic Therapy for Psoriasis: Successful Recovery in Two Patients After Infection with Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

open access: yesDermatology and Therapy, 2020
The outbreak of the novel coronavirus known as SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) causing COVID-19 was first reported in late December 2019.
Nicholas D. Brownstone   +6 more
doaj   +1 more source

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