Results 161 to 170 of about 322,632 (326)

Targeting CLEC4E in immunosuppressive tumour‐associated macrophages via BET inhibition

Clinical and Translational Medicine
Background Immunosuppressive tumour‐associated macrophages (TAMs) represent a promising target for cancer immunotherapy; however, existing TAM‐directed therapies have shown limited clinical efficacy. C‐type lectin domain family 4 member E (CLEC4E), a pro‐
Mengting Liao, Kexin Long, Liang Dong, Zhuo Li, Wenhua Wang, Rui Hu, Yangyi Zhang, Juan Su, Wu Zhu, Xiang Chen, Mingzhu Yin   +10 more
doaj   +1 more source

TAM pathway proteins as novel salivary biomarkers for periodontitis

Journal of Periodontology, EarlyView.
Abstract Background The identification of molecular biomarkers that help clinicians in early diagnosis is a key focus of periodontal research. The major aim of this cross‐sectional observational study was to assess whether salivary TAM pathway protein levels have the potential to discriminate between periodontally healthy or gingivitis controls and ...
Karina Mendes, Ana T. P. C. Gomes, Dimitris N. Tatakis, Tiago Marques, Marla Pinto, Pedro C. Lopes, Maria J. Correia, Nuno Rosa   +7 more
wiley   +1 more source

Generalized pustular psoriasis treated with apremilast in a patient with multiple medical comorbidities

JAAD Case Reports, 2017
Caleb Jeon, BS, Mio Nakamura, MD, Sahil Sekhon, MD, Di Yan, BA, Jashin J. Wu, MD, Wilson Liao, MD, Tina Bhutani, MD   +6 more
doaj   +1 more source

LZTR1 regulates epithelial MHC-I expression via NF-κB1 to modulate CD8+ T cells activation

Cell Discovery
The role of CD8+ tissue-resident memory T (CD8+ TRM) in inflammation is well established. However, the mechanisms by which CD8+ TRM cells are activated in tissues have remained elusive.
Rundong Jiang, Zhiqin Fang, Yutong Wang, Bo Huang, Junkun Liu, Lam C. Tsoi, Rachael Bogle, Zongbo Zhang, Yehong Kuang, Xin Li, Liang Dong, Liping Jin, Johann E. Gudjonsson, Mingzhu Yin, Xiang Chen   +14 more
doaj   +1 more source

ROLE OF VIRECHANOTTARA SANSHAMANA CHIKITSA IN THE MANAGEMENT OF EKAKUSHTHA (PSORIASIS VULGARIS): A CASE STUDY

, 2020
Niharika Shakya, Govind Kumar Verma, Ashutosh Chaturvedi, Ritisha Verma, Jai Prakash Singh   +4 more
openalex   +1 more source

Dextran sodium sulfate confounds causal role of periodontitis in inflammatory bowel disease

Journal of Periodontology, EarlyView.
Abstract Background Emerging evidence supports a bidirectional link between periodontitis and inflammatory bowel disease (IBD). To investigate this relationship, experimental models commonly use dextran sodium sulfate (DSS) to induce colitis. However, DSS is presumed to selectively affect the colon, and its potential off‐target effects on the oral ...
Himanshi Tanwar, Jeba Mercy Gnanasekaran, Niyant Ganesh, Cindy Zhou, Amy Plotkin, Giacomo Baima, Massimo Costalonga, Fenfen Zhou, Hanping Feng, Priyam Jani, Jean‐Pierre Raufman, Vivek Thumbigere‐Math   +11 more
wiley   +1 more source

Psoriasis [PDF]

BMJ, 2007
openaire   +2 more sources

Reshaping study design for faster extrapolation‐based drug approval in pediatric inflammatory bowel diseases: An ESPGHAN–NASPGHAN position paper

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Children with inflammatory bowel diseases (IBD) have limited access to the available advanced therapies, given the lengthy gap between adult and pediatric approval. We aimed to review key hurdles for pediatric trials and recommend practical solutions.
Dan Turner, Amit Assa, Mikkel Malham, Shira Yuval Bar‐Asher, Carla Rayan, Jeffrey S. Hyams, Holm H. Uhlig, Brad Pasternak, David C. Wilson, Hilary K. Michel, Lissy de Ridder, Eric Zuckerman, Marina Aloi, Peter Szitanyi, Marla C. Dubinsky, Anne M. Griffiths, Roberto Saldana, Javier Martín‐de‐Carpi, Eytan Wine, Richard K. Russell, Jeremy Adler, Joseph Picoraro   +21 more
wiley   +1 more source

Methotrexate toxicity and intolerance in paediatric inflammatory bowel disease: A retrospective cohort study

Journal of Pediatric Gastroenterology and Nutrition, EarlyView.
Abstract Objectives Methotrexate (MTX) is frequently prescribed in paediatric inflammatory bowel disease (IBD), with routine laboratory monitoring to detect adverse events (AEs), such as hepatotoxicity and myelotoxicity. However, data on the incidence and predictors of these AEs remain limited.
Eva Vermeer, Eveline L. Soetens, Eduard A. Struys, Johan E. van Limbergen, Maja Bulatović‐Ćalasan, Robert de Jonge, Nanne K. H. de Boer, Tim G. J. de Meij   +7 more
wiley   +1 more source

Peripheral blood cytokine levels in paediatric‐onset inflammatory bowel disease: A systematic review and meta‐analysis

JPGN Reports, EarlyView.
Abstract Objectives We aimed to summarise findings on blood cytokine levels in patients with paediatric‐onset inflammatory bowel disease (PIBD) compared to healthy controls. Methods This systematic review followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta‐Analyses) guidelines and was registered at Prospero (CRD42024579684 ...
Sabine Jansson, Andrea Ehrström, Charlotte Ulrikka Rask, Johan Burisch, Michael Eriksen Benros, Jakob Seidelin, Mikkel Malham, Vibeke Wewer   +7 more
wiley   +1 more source