Phosphatase targeting in Luminal B breast cancer: PGP.
Breast cancer can be positive for expression of a hormone receptor (ESR/PGR/AR) or a growth factor receptor (ERBB2). Disease recurrence following disease remission (relapse), resistance to endocrine therapy or otherwise inadequate long-term control of disease are challenges that limit effectiveness of existing drugs that treat luminal A and luminal B ...
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Journal of Inflammation ResearchJiale He, Kesong Li, Zilin Guo, Xinyao Zhou, Xiaopo Tang Department of Rheumatology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, People’s Republic of ChinaCorrespondence: Xinyao Zhou, Email xyz_1102@126.com Xiaopo ...
He J, Li K, Guo Z, Zhou X, Tang X
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Therapeutic targeting in breast cancer for the treatment of lung metastasis: SHB.
Metastasis is the major cause of death from cancer and metastasis to the lung in breast cancer is difficult to treat and heterogeneous in nature, complicating its management (1-5). We recently utilized whole transcriptome technologies to define the full complement of differentially expressed kinases and phosphatases in HER2+ breast cancer: in the ...
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Catalytic site targeting in HER2+ breast cancer for the treatment of CNS metastasis: PSPH.
Up to 50% of patients with HER2+ subtype breast cancer develop metastasis to the central nervous system, most commonly the brain, demanding rapid therapeutic approaches to limit spread of the HER2+ primary tumor to distant sites (1-3). We recently described the existence of a group of genes that reside proximal to ERBB2 (the gene that encodes the ...
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LIS1 mediated Schwann cell reprogramming enhances perineural invasion by activating the serine/NMDAR/AKT signaling pathway in head and neck squamous carcinoma. [PDF]
Cancer Cell IntLiu J +7 more
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We study breast cancer in humans as a model for understanding cancer as a system in its entirety and as a life cycle, including cell of origin, transformation, subtype selection, biology and ecology of the primary tumor, the tumor microenvironment, tumor immunology and surveillance, dissemination via the circulating tumor cell, metastasis to the lymph ...
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Development of the membranous labyrinth in E9.5 to E14.5 C57BL/6N mouse embryos. Stage specific metric and descriptive reference data and their use for identifying malformations. [PDF]
Front Cell Dev BiolMaurer-Gesek B, Geyer SH, Weninger WJ.
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Someone to rely on: the impact of social support on self-perceived health in Slovene elderly
, 2019 Introduction: Aiming at highlighting the importance of social networking for health of elderly, the association between social support and self-perceived health (SPH) was assessed in Slovenia.Methods: Data from three consecutive cross-sectional surveys ...
Vidovic, Spela +2 more
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Recent progress in serine metabolism reprogramming in tumors and strategies for serine deprivation. [PDF]
Front OncolLiu H, Liu Y.
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Metabolic remodeling and immune evasion in glioblastoma: a focus on serine and lipid networks. [PDF]
Front OncolJiang D, Wang C, Zhao Y, Li Y.
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