Results 111 to 120 of about 77,099 (293)

Diffusion of Carbamazepine in Hydrophobic Zeolites: A Comparative Study Using Classical and Machine‐Learned Potentials

Chemistry – A European Journal, EarlyView.
Can hydrophobic, shape‐selective zeolites efficiently remove the persistent pharmaceutical CBZ from water? This work moves beyond the static picture of interaction energies by modeling diffusion with umbrella sampling and machine‐learned potentials. Even high intrinsic diffusion barriers can be overcome through exergonic adsorption from water, yielding
Jakob Brauer, Richard Kendra, Carlos Bornes, Lukáš Grajciar, Michael Fischer   +4 more
wiley   +1 more source

2023: The Best Year Ever for Future Pharmacology (and Even Better Years to Come)

Future Pharmacology
The end of any year provides an opportunity to reflect on the past, and in particular, the past twelve months [...]
Fabrizio Schifano
doaj   +1 more source

Drug Critical Limits for Urgent Physician Notification

Clinical Pharmacology &Therapeutics, EarlyView.
Critical limits represent quantitative decision thresholds for drugs that require immediate clinician notification and potential life‐saving intervention. United States hospitals lack a national standard for drug critical limits. We collected critical limits from 417 US hospitals across all 50 states and Washington, D.C.; of these, 411 maintained drug ...
Elina Kuang, Yasmeen Ibrahim, Kyle Cheng, Gerald J. Kost   +3 more
wiley   +1 more source

New psychoactive substances: Challenges [PDF]

Hospital Pharmacology, 2020
Introduction: The United Nation Office of Drugs and Crime (UNODC) defines "new psychoactive substances" (NPS) as substances for abuse that are not under the control of the 1961 Convention on Narcotic Drugs or the 1971 Convention on Psychotropic ...
Crnić Katarina B., Kovačević Mira N.
doaj  

Registered Clinical Trials of Ayahuasca and DMT: A Scoping Review

Clinical Pharmacology &Therapeutics, EarlyView.
Interest in ayahuasca and its main component, N,N‐Dimethyltryptamine (DMT), has currently moved from historical and experimental use into modern clinical development. Yet, current evidence is fragmented, and systematic mapping of trial methods and design choices remains limited.
Tijana Stojanović, Kent W. Nilsson, Robert Fredriksson, Helgi B. Schiöth, Thiago C. Moulin   +4 more
wiley   +1 more source

COVID-19: The Hidden Impact on Mental Health and Drug Addiction

Frontiers in Psychiatry, 2020
Stefania Chiappini, Amira Guirguis, Amira Guirguis, Ann John, John Martin Corkery, Fabrizio Schifano   +5 more
doaj   +1 more source

Drugs Used in “Chemsex”/Sexualized Drug Behaviour—Overview of the Related Clinical Psychopharmacological Issues

Brain Sciences
Background: “Chemsex” involves the intake of a range of drugs (e.g., synthetic cathinones, gamma-hydroxybutyric acid/gamma-butyrolactone (GHB/GBL), ketamine, methamphetamine, “poppers”, type V phosphodiesterase (PDE) inhibitors, MDMA/ecstasy, cocaine ...
Fabrizio Schifano, Stefania Bonaccorso, Davide Arillotta, Amira Guirguis, John Martin Corkery, Giuseppe Floresta, Gabriele Duccio Papanti Pelletier, Norbert Scherbaum, Nicolò Schifano   +8 more
doaj   +1 more source

A Novel Workflow for Fast Elucidation of Drug Metabolites for Screening—Combining In Silico Metabolite Prediction With Trapped Ion Mobility QTOF‐MS

Drug Testing and Analysis, EarlyView.
UHPLC‐timsTOF‐MS with in silico prediction and automated annotation enabled rapid identification of quetiapine metabolites from pHLMs, facilitating their inclusion in targeted LC‐QTOF‐MS urine screening and improving biomarker detection for toxicological applications.
Annette Zschiesche, Birgit Schneider, Ilona Nordhorn, Carsten Baessmann, Laura M. Huppertz, Jürgen Kempf   +5 more
wiley   +1 more source

Effect of Reaction Time and Temperature on the Impurity Profile of Amphetamine in the Leuckart Method

Drug Testing and Analysis, EarlyView.
This study investigates the effect of the reaction temperature (step 1) and reaction time (step 1 and 2) on the conversion efficiency and impurity profile of amphetamine synthesized via the Leuckart method. Conversion efficiency and impurity profile were assessed using gas chromatography–flame ionization detection (GC–FID) and GC–mass spectrometry (GC ...
Maartje C. M. Verhoeven, Robert C. Huls, Nelly W. van der Stelt, Jelle C. de Koning, Marco van Grol, Ruben F. Kranenburg, Arian C. van Asten, Janneke W. Hulshof   +7 more
wiley   +1 more source

Market Analysis of Synthetic Drugs: Amphetamine-type Stimulants, New Psychoactive Substances [PDF]

, 2017
An estimated quarter of a billion people, or around 5 per cent of the global adult population, used drugs at least once in 2015. Even more worrisome is the fact that about 29.5 million of those drug users, or 0.6 per cent of the global adult population ...

core