Results 61 to 70 of about 233,257 (341)

Discovery of a Novel and Potent Kir4.1 Inhibitor as a Safe and Rapid‐Onset Antidepressant Agent in Mice

Advanced Science, EarlyView.
The preferred derivative JX3212 demonstrates strong inhibitory activity against Kir4.1 with favorable druggability and shows significant antidepressant efficacy in vivo. Abstract Major depressive disorder is a serious psychiatric disorder for which novel and fast‐acting antidepressants are required.
Sisi Wang, Xiaoyu Zhou, Mengdan Li, Chao Zhang, Haiyan Xu, Jingyi He, Li Zhan, Yueling Gu, Hao Gu, Tianyu Tu, Hanfang Liu, Taotao Lu, Yueming Zheng, Jian Li, Zhaobing Gao, Yixiang Xu   +15 more
wiley   +1 more source

Cannabis and psychosis : the Maltese contribution [PDF]

, 2010
Three different Maltese scientists have contributed to research on the link between cannabis and psychosis. The object of this article is to review and chronicle the work that has been done by these three colleagues in this field.
Agius, Mark, Grech, Anton, Zammit, Stanley   +2 more
core  

Light Therapy Alleviates Addiction‐Related Symptoms and Reshapes Habenula and Midbrain Pathways

Advanced Science, EarlyView.
This study investigates light therapy for treating Internet Gaming Disorder (IGD). Functional MRI (fMRI) data reveal that light therapy enhances brain connectivity, particularly between the habenula and the medial orbitofrontal cortex (mOFC). These changes are associated with reduced withdrawal symptoms and addiction severity, highlighting the ...
Jinhui Li, Huiyang Huang, Cunhao Hu, Xuan Zhang, Song Lin, Xiaodan Huang, Ti‐fei Yuan, Kwok‐Fai So, Lu Huang, Chaoran Ren, Qian Tao   +10 more
wiley   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

A case report of adolescent lactation due to the drug blonanserin

BMC Psychiatry
Background Second-generation antipsychotic drugs are increasingly used to treat depressive disorders with psychotic symptoms. In addition to effectively managing psychotic symptoms, second-generation antipsychotics can also result in adverse drug ...
Peiyuan Tang, Chongze Wang, Wu Hong, Zhenghui Yi, Qinyu Lv   +4 more
doaj   +1 more source

PSYCHOSIS AND DEPRESSION – A NEUROBIOLOGICAL VIEW [PDF]

, 2009
Psychosis and depression are syndromes that affect the most basic human processes of perception and judgment. Traditional dichotomous classification of psychotic and affective disorders resolved in strict separation between schizophrenia on one hand and ...
Peter Pregelj
core   +1 more source

Negative cognition, affect, metacognition and dimensions of paranoia in people at ultra-high risk of psychosis: a multi-level modelling analysis [PDF]

, 2015
Background: Paranoia is one of the commonest symptoms of psychosis but has rarely been studied in a population at risk of developing psychosis. Based on existing theoretical models, including the proposed distinction between ‘poor me’ and ‘bad me ...
Bentall, R.P., Birchwood, M., Fowler, D., French, P., Gumley, A.I., Jones, P.B., Lewis, S.W., Morrison, A.P., Shryane, N., Stewart, S.L.K., Taylor, H.E.   +10 more
core   +2 more sources

Laparoscopic and Endoscopic Cooperative Surgery for Gastric Cancer as an Alternative Treatment in Elderly Patients: A Prospective Observational Study

Annals of Gastroenterological Surgery, EarlyView.
In a prospective study of 20 elderly gastric cancer patients who declined gastrectomy, laparoscopic and endoscopic cooperative surgery (LECS) was technically safe and preserved postoperative function. However, as oncological curability cannot be assured in advanced cases, careful selection and informed consent are essential.
Marie Washio, Keishi Yamashita, Takuya Wada, Mikiko Sakuraya, Hiroki Harada, Tadashi Higuchi, Koshi Kumagai, Yasushi Orihashi, Chika Kusano, Naoki Hiki   +9 more
wiley   +1 more source

Interactions between variation in candidate genes and environmental factors in the etiology of schizophrenia and bipolar disorder : a systematic review [PDF]

, 2018
Schizophrenia and bipolar disorder (BD) are complex and multidimensional disorders with high heritability rates. The contribution of genetic factors to the etiology of these disorders is increasingly being recognized as the action of multiple risk ...
Frydecka, Dorota, Gawęda, Łukasz, Misiak, Błażej, Mustafa, Ahmed A, Prochwicz, Katarzyna, Stramecki, Filip, Sąsiadek, Maria M   +6 more
core  

Local gyrification index in probands with psychotic disorders and their first-degree relatives [PDF]

, 2014
BACKGROUND: Psychotic disorders are characterized by aberrant neural connectivity. Alterations in gyrification, the pattern and degree of cortical folding, may be related to the early development of connectivity. Past gyrification studies have relatively
Abhishekh, Hulegar A, Clementz, Brett A, Giakoumatos, Christoforos I, Keshavan, Matcheri S, Mathew, Ian T, Nanda, Pranav, Pearlson, Godfrey D, Sweeney, John, Tamminga, Carol A, Tandon, Neeraj   +9 more
core   +1 more source