Longitudinal change and prognostic significance of serum PINK1 levels, and mediation role of delayed cerebral ischemia in human aneurysmal subarachnoid hemorrhage: an observational analytical study [PDF]
Frontiers in NeurologyBackgroundPTEN-induced putative kinase 1 (PINK1) is an endogenous protective protein. This study analyzed the prognostic implications of serum PINK1 levels and assessed the mediation effect of delayed cerebral ischemia (DCI) in human aneurysmal ...
Guo-Jun He +5 more
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Mutations in PTEN-induced putative kinase 1 associated with recessive parkinsonism have differential effects on protein stability [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2005 Several mutations in PTEN-induced putative kinase 1 ( PINK1 ) gene have been reported to be associated with recessive parkinsonism. The encoded protein is predicted to be a Ser/Thr protein kinase targeted to mitochondria.
Alexandra Beylina +2 more
exaly +3 more sources
Efficacy of nicotiflorin in ameliorating septic acute kidney injury: the role of PINK1/parkin in mitochondrial restoration and oxidative stress reduction [PDF]
Renal FailureObjectives: Nicotiflorin has demonstrated efficacy in mitigating acute liver injury, and therefore, its potential in treating septic acute kidney injury (AKI) merits further investigation.
Zhuangzhi Yang +3 more
doaj +2 more sources
Protective effect of resveratrol on rat cardiomyocyte H9C2 cells injured by hypoxia/reoxygenation by regulating mitochondrial autophagy PTEN-induced putative kinase protein 1/Parkinson disease protein 2 signaling pathway. [PDF]
J Tradit Chin Med, 2022 To investigate the protective effect of resveratrol on cardiomyocytes after hypoxia/ reoxygenation intervention based on PTEN-induced putative kinase protein 1/Parkinson disease protein 2 (PINK1/PARKIN) signaling pathway.3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenylte-trazolium bromide was used to detect the effect of resveratrol on the viability of H9C2 ...
Lixia Z, Wei S, Decheng B.
europepmc +3 more sources
Curcumin ameliorates hepatic insulin resistance by activating PINK1/Parkin-mediated mitophagy [PDF]
Scientific ReportsInsulin resistance (IR) is the key pathogenic factor of type 2 diabetes (T2DM) and its associated metabolic diseases. Mitochondrial dysfunction and inadequate mitophagy are central to this pathology. Curcumin, the main bioactive compound of Curcuma longa,
Zhanhong Guo, Huan Zhang, Yinghong Kong
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Mitophagy Regulation Following Myocardial Infarction
Cells, 2022 Mitophagy, which mediates the selective elimination of dysfunctional mitochondria, is essential for cardiac homeostasis. Mitophagy is regulated mainly by PTEN-induced putative kinase protein-1 (PINK1)/parkin pathway but also by FUN14 domain-containing 1 (
Annie Turkieh +3 more
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Open Medicine, 2021 Mitophagy affects the activation of hepatic stellate cells (HSCs). Mitochondria-targeted ubiquinone (MitoQ) is a mitochondria-targeted antioxidant that reduces the production of intracellular reactive oxygen species (ROS).
Dou Shi-Ying +7 more
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Modeling Parkinson’s Disease Using Induced Pluripotent Stem Cells
Stem Cells International, 2020 Parkinson’s disease (PD) is the second most common neurodegenerative disease. The molecular mechanisms of PD at the cellular level involve oxidative stress, mitochondrial dysfunction, autophagy, axonal transport, and neuroinflammation.
Xinchao Hu +12 more
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Temporal integration of mitochondrial stress signals by the PINK1:Parkin pathway
BMC Molecular and Cell Biology, 2019 Background The PINK1:Parkin pathway regulates the autophagic removal of damaged and dysfunctional mitochondria. While the response of this pathway to complete loss of ΔΨm, as caused by high concentrations of mitochondrial ionophores, has been well ...
J. Logan Bowling +5 more
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