Results 31 to 40 of about 22,716 (169)

The Ubiquitin E3 Ligase Parkin Inhibits Innate Antiviral Immunity Through K48-Linked Polyubiquitination of RIG-I and MDA5

Frontiers in Immunology, 2020
Innate immunity is the first-line defense against antiviral or antimicrobial infection. RIG-I and MDA5, which mediate the recognition of pathogen-derived nucleic acids, are essential for production of type I interferons (IFN).
Lang Bu, Huan Wang, Panpan Hou, Shuting Guo, Miao He, Jingshu Xiao, Ping Li, Yongheng Zhong, Penghui Jia, Yuanyuan Cao, Guanzhan Liang, Chenwei Yang, Lang Chen, Deyin Guo, Chun-Mei Li   +14 more
doaj   +1 more source

Puerarin alleviates cadmium-induced mitochondrial mass decrease by inhibiting PINK1–Parkin and Nix-mediated mitophagy in rat cortical neurons

Ecotoxicology and Environmental Safety, 2022
Cadmium (Cd) has well-known central nervous system toxicity, and mitochondria are direct targets of Cd-induced neuronal toxicity. However, how Cd induces mitochondrial mass decrease in terms of its neurotoxic effects remains unknown.
Shuangquan Wen, Li Wang, Tao Wang, Mingchang Xu, Wenhua Zhang, Ruilong Song, Hui Zou, Jianhong Gu, Jianchun Bian, Yan Yuan, Zongping Liu   +10 more
doaj   +1 more source

The role of mitophagy in cognitive impairment in aluminum-exposed rats

Zhongguo gonggong weisheng
ObjectiveTo observe the effects of subchronic aluminum exposure on the expression of PTEN-induced kinase 1 (PINK1)/E3 ubiquitin ligase (Parkin) pathway microtubule-associated protein 1 light chain 3B (LC3B), selective autophagy receptor protein 62 (P62),
Xiaoyu ZHANG, Yan LIU, Chaoqun XU, Xia YUAN, Kaiwen TAN, Jiacheng ZHOU, Binhong WANG, Xinru CHEN, Bin JIANG, Huan CHEN, Li LIN, Jing ZHANG, Huan LI   +12 more
doaj   +1 more source

STOML2 potentiates metastasis of hepatocellular carcinoma by promoting PINK1-mediated mitophagy and regulates sensitivity to lenvatinib

Journal of Hematology & Oncology, 2021
Background Dysregulation of both mitochondrial biogenesis and mitophagy is critical to sustain oncogenic signaling pathways. However, the mechanism of mitophagy in promoting hepatocellular carcinoma (HCC) progression remains poorly understood.
Yahui Zheng, Chong Huang, Lu Lu, Kangkang Yu, Jing Zhao, Mingquan Chen, Lu Liu, Qingfeng Sun, Zhifei Lin, Jianming Zheng, Jinhong Chen, Jubo Zhang   +11 more
doaj   +1 more source

Analysis on the Susceptibility Genes in Two Chinese Pedigrees with Familial Parkinson's Disease

Neurology Research International, 2010
Objective. To screen the susceptibility genes in Chinese pedigrees with early-onset familial Parkinson's disease (FPD). Methods. Fifty-one genomic DNA samples extracted from two Chinese pedigrees with FPD, the alpha-synuclein genes (SNCA), the leucine ...
Changshui Xu, Jun Xu, Yanmin Zhang, Jianjun Ma, Hideshi Kawakami, Hirofumi Maruyama, Masaki Kamada   +6 more
doaj   +1 more source

PINK1 Protects Against Gentamicin-Induced Sensory Hair Cell Damage: Possible Relation to Induction of Autophagy and Inhibition of p53 Signal Pathway

Frontiers in Molecular Neuroscience, 2018
Phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) is a gatekeeper of mitochondrial quality control. The present study was aimed to examine whether PINK1 possesses a protective function against gentamicin (GM)-induced sensory hair ...
Qianqian Yang, Qianqian Yang, Yiwei Zhou, Haiyan Yin, Haiyan Yin, Hongrui Li, Meijuan Zhou, Meijuan Zhou, Gaoying Sun, Gaoying Sun, Zhixin Cao, Rongjun Man, Haibo Wang, Haibo Wang, Jianfeng Li, Jianfeng Li, Jianfeng Li   +16 more
doaj   +1 more source

Gerontoxanthone I and Macluraxanthone Induce Mitophagy and Attenuate Ischemia/Reperfusion Injury

Frontiers in Pharmacology, 2020
Mitophagy is a crucial process in controlling mitochondrial biogenesis. Balancing mitophagy and mitochondrial functions is required for maintaining cellular homeostasis.
Qian Xiang, Qian Xiang, Man Wu, Man Wu, Li Zhang, Li Zhang, Wenwei Fu, Wenwei Fu, Jinling Yang, Jinling Yang, Baojun Zhang, Baojun Zhang, Zhaoqing Zheng, Zhaoqing Zheng, Hong Zhang, Hong Zhang, Yuanzhi Lao, Yuanzhi Lao, Hongxi Xu   +18 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

The Mitochondria-Regulated Immune Pathway Activated in the C. elegans Intestine Is Neuroprotective

Cell Reports, 2016
Immunological mediators that originate outside the nervous system can affect neuronal health. However, their roles in neurodegeneration remain largely unknown.
Madhusudana Rao Chikka, Charumathi Anbalagan, Katherine Dvorak, Kyle Dombeck, Veena Prahlad   +4 more
doaj   +1 more source

PINK1/Parkin-mediated mitophagy modulates cadmium-induced apoptosis in rat cerebral cortical neurons

Ecotoxicology and Environmental Safety, 2022
Cadmium is a persistent environmental pollutant whose neurotoxicity is of serious concern. Mitochondrial dysfunction and its mediated mitophagy and apoptosis are considered key events in Cd-induced neurological pathologies, but the exact molecular ...
Shuangquan Wen, Li Wang, Chaofan Zhang, Ruilong Song, Hui Zou, Jianhong Gu, Xuezhong Liu, Jianchun Bian, Zongping Liu, Yan Yuan   +9 more
doaj   +1 more source