Results 21 to 30 of about 22,716 (169)
PINK1 deficiency in β-cells increases basal insulin secretion and improves glucose tolerance in mice [PDF]
Open Biology, 2014 The Parkinson's disease (PD) gene, PARK6, encodes the PTEN-induced putative kinase 1 (PINK1) mitochondrial kinase, which provides protection against oxidative stress-induced apoptosis. Given the link between glucose metabolism, mitochondrial function and
Emma Deas +7 more
doaj +1 more source
Antioxidants, 2023 Endothelial senescence impairs vascular function and thus is a primary event of age-related vasculature diseases. Isocitrate dehydrogenase 2 (IDH2) plays an important role in inducing alpha-ketoglutarate (α-KG) production and preserving mitochondrial ...
Ikjun Lee +8 more
doaj +1 more source
Dysfunctional Mitochondria Clearance in Situ: Mitophagy in Obesity and Diabetes-Associated Cardiometabolic Diseases [PDF]
Diabetes & Metabolism JournalSeveral mitochondrial dysfunctions in obesity and diabetes include impaired mitochondrial membrane potential, excessive mitochondrial reactive oxygen species generation, reduced mitochondrial DNA, increased mitochondrial Ca2+ flux, and mitochondrial ...
Songling Tang +8 more
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Cell Reports, 2015 Mitochondrial Ca2+ overload is a critical, preceding event in neuronal damage encountered during neurodegenerative and ischemic insults. We found that loss of PTEN-induced putative kinase 1 (PINK1) function, implicated in Parkinson disease, inhibits the ...
Marko Kostic +7 more
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Parkinson’s disease-implicated kinases in the brain; insights into disease pathogenesis.
Frontiers in Molecular Neuroscience, 2014 Substantial evidence implicates abnormal protein kinase function in various aspects of Parkinson’s disease (PD) etiology. Elevated phosphorylation of the PD-defining pathological protein, α-synuclein, correlates with its aggregation and toxic ...
Nicolas eDzamko +5 more
doaj +1 more source
Autoimmunity, 2022 Rheumatoid arthritis (RA) often leads to functional disabilities and deformities. MiRNA plays a vital role in cell pyroptosis. Nevertheless, the function and underlying mechanism of miR-144-3p in pyroptosis during the progression of RA remains unclear ...
Jin-Mei Jiang +3 more
doaj +1 more source
PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1.
PLoS Biology, 2007 Mutations in the PTEN induced putative kinase 1 (PINK1) gene cause an autosomal recessive form of Parkinson disease (PD). So far, no substrates of PINK1 have been reported, and the mechanism by which PINK1 mutations lead to neurodegeneration is unknown ...
Julia W Pridgeon +3 more
doaj +1 more source
Stem Cell Research, 2018 Parkinson's disease (PD) is a neurodegenerative disease with unknown etiology. Here we show the generation of an induced pluripotent stem cell (iPSC) line, named CSC-40, from dermal fibroblasts obtained from a 59-year-old male patient with a homozygous p.
Kaspar Russ +6 more
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Deciphering the dual role and prognostic potential of PINK1 across cancer types
Neural Regeneration Research, 2021 Metabolic rewiring and deregulation of the cell cycle are hallmarks shared by many cancers. Concerted mutations in key tumor suppressor genes, such as PTEN, and oncogenes predispose cancer cells for marked utilization of resources to fuel accelerated ...
Katherine Dai +2 more
doaj +1 more source
Mitochondrial Protein PINK1 Positively Regulates RLR Signaling
Frontiers in Immunology, 2019 The serine/threonine kinase phosphatase and tensin homolog (PTEN)-induced putative kinase 1(PINK1) controls mitochondrial quality and plays a vital role in the pathogenesis of early-onset Parkinson's disease.
Jun Zhou +9 more
doaj +1 more source