Puerarin attenuates S. aureus-induced mastitis through inhibiting inflammation and ferroptosis by activating the SIRT1/p53/SLC7A11 signaling pathway [PDF]
Microbiology SpectrumMastitis, one of the most prevalent diseases in humans and animals, is commonly caused by local infection of the mammary gland. Puerarin inhibits mitochondrial oxidative stress and acute liver injury in mice.
Yang Yang +3 more
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Formation mechanism and ultrasound-assisted preparation of puerarin emulsions [PDF]
Food Chemistry: XCombining experimental and computational methods, this study elucidated puerarin's behavior at oil/water interfaces, culminating in the formulation of puerarin-based emulsions.
Chengyun He +3 more
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Puerarin affects adipose lipolysis and ameliorates obesity by gut microbiota [PDF]
Frontiers in MicrobiologyBackgroundObesity has become a widespread metabolic disorder, marked by its escalating global prevalence. Puerarin, extracted from Pueraria lobata, one of the traditional homologies of medicine and food, demonstrates anti-obesity properties. Nonetheless,
Zhaoyi Li +6 more
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Puerarin Ameliorates the Ferroptosis in Diabetic Liver Injure Through the JAK2/STAT3 Pathway Inhibition Based on Network Pharmacology and Experimental Validation [PDF]
Drug Design, Development and TherapyXiaoxu Fan,1 Shuangqiao Liu,1 Jing Yu,2 Jian Hua,1 Yingtong Feng,1 Zhen Wang,1 Yiwei Shen,1 Wei Lan,2 Jingxia Wang1 1School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2School of ...
Fan X +8 more
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Puerarin inhibits EMT induced by oxaliplatin via targeting carbonic anhydrase XII
Frontiers in Pharmacology, 2022 Puerarin is a flavonoid molecule that widely exists in various plants. Puerarin has been reported to exhibit anti-tumor effects in various cancers. However, its exact underlying pharmacological mechanism is unclear.
Xindong Chen +8 more
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Puerarin Attenuates Diabetic Nephropathy by Promoting Autophagy in Podocytes
Frontiers in Physiology, 2020 Puerarin, an active compound of radix puerariae, is a major compound used in Chinese herbal medicines to treat patients with diabetic nephropathy (DN).
Xueling Li +7 more
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Puerarin induces platinum-resistant epithelial ovarian cancer cell apoptosis by targeting SIRT1
Journal of International Medical Research, 2021 Objective Previous investigations indicated the anticancer activity of puerarin. The current study aimed to evaluate the effect and molecular mechanisms of puerarin in chemotherapy-resistant ovarian cancer cells.
Jianxiu Duan +4 more
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Molecular Mechanism of Puerarin Against Diabetes and its Complications
Frontiers in Pharmacology, 2022 Puerarin is a predominant component of Radix Puerarin. Despite its anti-tumor and anti-virus effects and efficacy in improving cardiovascular or cerebrovascular diseases and preventing osteoporosis, it has been shown to protect against diabetes and its ...
Yi-ling Bai +3 more
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Optimizing adipogenic transdifferentiation of bovine mesenchymal stem cells: a prominent role of ascorbic acid in FABP4 induction [PDF]
, 2020 Adipocyte differentiation of bovine adipose-derived stem cells (ASC) was induced by foetal bovine serum (FBS), biotin, pantothenic acid, insulin, rosiglitazone, dexamethasone and 3-isobutyl-1-methylxanthine, followed by incubation in different media to ...
Aschenbach, Jörg R. +6 more
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Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes [PDF]
, 2017 Cardiovascular diseases are the main cause of mortality and morbidity in the world. Hypertension, ischemia/reperfusion, diabetes and anti-cancer drugs contribute to heart failure through oxidative and nitrosative stresses which cause cardiomyocytes ...
Bei, Roberto +10 more
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