Results 171 to 180 of about 8,591 (223)

Puerarin-induced immune hemolytic anemia

International Journal of Hematology, 2013
Drug-induced immune hemolytic anemia (DIIHA) is a relatively uncommon condition characterized by a sudden drop in hemoglobin, putatively following exposure to drugs. Severe forms of hemolysis characterized by rapidly falling hemoglobin levels and hemoglobinuria are extremely rare.
Fei, Chen, Shangqin, Liu, Jiang, Wu
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Puerarin Accelerates Peripheral Nerve Regeneration

The American Journal of Chinese Medicine, 2011
This study investigates the effect of puerarin (PR) on peripheral nerve regeneration in vitro and in vivo. PR at concentrations of 1, 10, and 100 μM significantly promoted survival and outgrowth of cultured Schwann cells, as compared to the controls treated with culture medium only.
Shih-Wei, Hsiang, Han-Chung, Lee, Fuu-Jen, Tsai, Chin-Chuan, Tsai, Chun-Hsu, Yao, Yueh-Sheng, Chen   +5 more
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Permeabilization of Microbacterium oxylans shifts the conversion of puerarin from puerarin-7-O-glucoside to puerarin-7-O-fructoside

Applied Microbiology and Biotechnology, 2009
The main product of the conversion of puerarin by unpermeabilized cells of bacterium Microbacterium oxydans CGMCC 1788 was puerarin-7-O-glucoside (241 +/- 31.9 microM). Permeabilization with 40% ethanol could not increase conversion yield, whereas it resulted in change of main product; a previous trace product became a main product (213 +/- 48.0 microM)
Cigang, Yu, Haidong, Xu, Guodong, Huang, Ting, Chen, Guiyou, Liu, Nan, Chai, Yin, Ji, Siyuan, Wang, Yijun, Dai, Sheng, Yuan   +9 more
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A Supramolecular Hydrogel of Puerarin

Journal of Biomedical Nanotechnology, 2018
Supramolecular hydrogels have drawn increased attention because of their advantages in facile synthesis, biocompatibility, easy degradation and fast responses to external stimuli. Until now, the example of hydrogelators of pure natural resources has rarely been reported.
Yanbin, Cai, Jianwu, Zhang, Yingyan, He, Zehua, Li, Yongquan, Hua, Zhiye, Wu, Jie, Gao, Caiwen, Ou, Minsheng, Chen   +8 more
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In vitro enzymatic modification of puerarin to puerarin glycosides by maltogenic amylase

Carbohydrate Research, 2004
Puerarin (daidzein 8-C-glucoside), the most abundant isoflavone in Puerariae radix, is prescribed to treat coronary heart disease, cardiac infarction, problems in ocular blood flow, sudden deafness, and alcoholism. However, puerarin cannot be given by injection due to its low solubility in water.
Dan, Li, Sung-Hoon, Park, Jae-Hoon, Shim, Hee-Seob, Lee, Shuang-Yan, Tang, Cheon-Seok, Park, Kwan-Hwa, Park   +6 more
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Pharmacokinetic, Tissue Distribution, and Excretion of Puerarin and Puerarin-Phospholipid Complex in Rats

Drug Development and Industrial Pharmacy, 2006
Puerarin is a potential therapeutic agent for cardiovascular diseases. But its poor oral bioavailability restricts its clinical application. In present study, as an evaluation of a formulation to improve the bioavailability of the drug, puerarin and its phospholipid complex were given to rats by intragastrically (i.g.) administration to compare ...
Y, Li, W S, Pan, S L, Chen, H X, Xu, D J, Yang, A S C, Chan   +5 more
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Interactions between puerarin/daidzein and micellar casein

Journal of Food Biochemistry, 2022
Puerarin (PUE) and daidzein (DAI) are polyphenols with extensive biological activities. In the present study, the interactions between PUE/DAI and micellar casein (MC) were investigated, and the physicochemical properties of their complexes were analyzed.
Yucheng Wang, Min Yang, Juanjuan Qin, Wenqiang Wa   +3 more
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Puerarin injection for unstable angina pectoris

Cochrane Database of Systematic Reviews, 2006
Puerarin is extracted from the Chinese herb puerariae lobata. Many users of Chinese herbal medicine believe that puerarin has positive effects in the treatment of coronary heart disease (CHD). In recent years puerarin injection has been widely used to treat CHD and angina pectoris.To assess the benefits and harms of puerarin injection for unstable ...
Q, Wang, T, Wu, X, Chen, J, Ni, X, Duan, J, Zheng, J, Qiao, L, Zhou, J, Wei   +8 more
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Puerarin: A Review of Pharmacological Effects

Phytotherapy Research, 2013
Puerarin is the major bioactive ingredient isolated from the root of the Pueraria lobata (Willd.) Ohwi, which is well known as Gegen (Chinese name) in traditional Chinese medicine. As the most abundant secondary metabolite, puerarin was isolated from Gegen in the late 1950s. Since then, its pharmacological properties have been extensively investigated.
Yan-Xi, Zhou, Hong, Zhang, Cheng, Peng
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Role of the interaction between puerarin and the erythrocyte membrane in puerarin-induced hemolysis

Chemico-Biological Interactions, 2011
Adverse drug reactions (ADR), especially intravenous hemolysis, have largely limited the application of puerarin injections in clinics. This study investigated the underlying mechanisms of puerarin-induced hemolysis. Our results show that puerarin induced concentration-dependent and time-dependent hemolysis when human erythrocytes were incubated in ...
Shao-Zhen, Hou, Zi-Ren, Su, Shu-Xian, Chen, Mu-Rong, Ye, Song, Huang, Liang, Liu, Hua, Zhou, Xiao-Ping, Lai   +7 more
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