Results 41 to 50 of about 8,591 (223)

Peran Puerarin terhadap Aktivitas Intra dan Ekstraseluler pada Kultur Human Umbilical Vein Endothelial Cells (HUVECs) Pasca Induksi Leptin

Journal of Experimental Life Science, 2011
Beberapa penelitian terkini menyebutkan bahwa leptin merupakan salah satu penyebab disfungsi endotel yang merupakan salah satu penyebab aterogenesis. Antioksidan puerarin diduga memiliki kemampuan untuk mencegah mekanisme aterogenesis yang distimulasi ...
Mochamad Sasmito Djati, Satuman Satuman, Sri Widyarti, Erly Nur Aisyah, Noer Hasanah, Eko Puji Astuti, Ririn Rochmawati   +6 more
doaj   +1 more source

Puerarin ameliorates metabolic dysfunction-associated fatty liver disease by inhibiting ferroptosis and inflammation

Lipids in Health and Disease, 2023
Metabolic dysfunction-associated fatty liver disease (MAFLD) is frequently linked to type 2 diabetes mellitus (T2DM), and both conditions exacerbate the progression of the other. However, there is currently no standardized treatment or drug for MAFLD. In
Mengmeng Yang, Longqing Xia, Jia Song, Huiqing Hu, Nan Zang, Jingwen Yang, Ying Zou, Liming Wang, Xiaoyue Zheng, Qin He, Jidong Liu, Fuqiang Liu, Kai Liang, Lei Sun, Li Chen   +14 more
doaj   +1 more source

Puerarin Alleviates Depression-Like Behavior Induced by High-Fat Diet Combined With Chronic Unpredictable Mild Stress via Repairing TLR4-Induced Inflammatory Damages and Phospholipid Metabolism Disorders

Frontiers in Pharmacology, 2021
Puerarin has been reported as a potential agent for neuro-inflammatory disorders. However, there have been no reports of using puerarin for the treatment of depression based on Toll-like receptor 4 (TLR4)–mediated inflammatory injury.
Li-Na Gao, Li-Na Gao, Maocai Yan, Lirun Zhou, Lirun Zhou, Jian’an Wang, Chunmei Sai, Yingjie Fu, Yang Liu, Lin Ding   +9 more
doaj   +1 more source

Biotransformation of puerarin into puerarin-6″-O-phosphate by Bacillus cereus

Journal of Industrial Microbiology and Biotechnology, 2012
Abstract The biotransformation of puerarin catalyzed by Bacillus cereus NT02 was studied. A primary screening was carried out using 307 strains of bacteria isolated from soil which were able to grow in the presence of puerarin. Strain NT02, identified as B. cereus, was able to convert puerarin into puerarin-6″-O-phosphate.
Lijuan, Yu, Fang, Gao, Liping, Yang, Lei, Xu, Zhaohui, Wang, Hui, Ye   +5 more
openaire   +2 more sources

Upregulation of UDP-Glucuronosyltransferases 1a1 and 1a7 Are Involved in Altered Puerarin Pharmacokinetics in Type II Diabetic Rats

Molecules, 2018
Puerarin is an isoflavonoid extracted from Pueraria lobata roots, and displays a broad range of pharmacological activities, including antidiabetic activity. However, information about the pharmacokinetics of puerarin in diabetics is scarce.
Songtao Dong, Maofan Zhang, Huimin Niu, Kunyu Jiang, Jialei Jiang, Yinglin Ma, Xin Wang, Shengnan Meng   +7 more
doaj   +1 more source

Puerarin alleviates sleep disorders in aged mice related to repairing intestinal mucosal barrier

Natural Products and Bioprospecting, 2023
More and more evidence suggests that puerarin, a potential remedy for gut inflammation, may have an ameliorative effect on sleep disturbances. However, the relationship between puerarin and sleep disruption has not been extensively researched. This study
Qing Tao, Jinhua Zhang, Qiao liang, Shiyu Song, Shuxia Wang, Xiaoming Yao, Qian Gao, Lei Wang   +7 more
doaj   +1 more source

Phytochemical profiling of underexploited Fabaceae species: Insights on the ontogenic and phylogenetic effects over isoflavone levels [PDF]

, 2017
There is an increasing trend towards finding alternative sources of valued phytochemicals due to their diverse potentialities in food industry and pharmaceutical applications.
Barreira, João C.M., Nunes, Eugénia, Oliveira, Beatriz, Pereira, Graça, Visnevschi-Necrasov, Tatiana   +4 more
core   +1 more source

Remimazolam Ameliorates Autistic‐Like Behaviors via Suppression of Ferroptosis in VTA Dopaminergic Neurons in a Mouse Model of ASD

Advanced Science, EarlyView.
The ultra‐short‐acting sedative remimazolam has a sustained therapeutic effect on the core symptoms of VPA‐exposed mice. Remimazolam, a GABA agonist, exerts its therapeutic effects by protecting dopamine neurons in the VTA of VPA‐exposed mice. Meanwhile, ferroptosis is the critical mechanism by which remimazolam protects VTA dopaminergic neurons and ...
Yuxin Zhang, Jianwei Lin, Chaoyang Tong, Xin Fu, Mengqin Shan, Yue Huang, Kan Zhang, Jijian Zheng   +7 more
wiley   +1 more source

Puerarin ameliorates non-alcoholic fatty liver disease by inhibiting lipid metabolism through FMO5

Frontiers in Pharmacology
Introduction:Pueraria lobata is traditionally used in China for treatment of non-alcoholic fatty liver disease (NAFLD). Puerarin, a functional drug extracted from Pueraria lobata, features a pharmacological activity. The present study aims to investigate
Zhaoyi Li, Zhaoyi Li, Wenjing Cao, Yuxuan Zhang, Shanglei Lai, Yingyan Ye, Jianfeng Bao, Jianfeng Bao, Ai Fu, Ai Fu   +9 more
doaj   +1 more source

Theoretical study on the glycosidic C–C bond cleavage of 3’’-oxo-puerarin

Scientific Reports, 2023
Puerarin, daidzein C-glucoside, was known to be biotransformed to daidzein by human intestinal bacteria, which is eventually converted to (S)-equol. The metabolic pathway of puerarin to daidzein by DgpABC of Dorea sp. PUE strain was reported as puerarin (
Jongkeun Choi, Yongho Kim, Bekir Engin Eser, Jaehong Han   +3 more
doaj   +1 more source