Results 51 to 60 of about 8,591 (223)
Applied Sciences, 2021 The delayed and impaired wound healing caused by dexamethasone (DEX) is commonly reported. Puerarin, the major isoflavone found in Pueraria montana var. lobata (Willd.) Sanjappa & Pradeep promoted the wound healing process in diabetic rats.
Ly Thi Huong Nguyen +4 more
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Treatment with Pueraria mirifica extract prevented muscle atrophy and restored muscle strength in ovariectomized rats [PDF]
, 2017 Pueraria mirifica (PM) is a phytoestrogen-rich plant that was tested to establish if its phytosteroids could prevent estrogen dependent sarcopenia. The effect of PM on the estrogen levels, estrous cycle, toxicity, muscle mass, strength and endurance of ...
Ekkasit Kumarnsit, +4 more
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Advanced Science, EarlyView.Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin +12 more
wiley +1 more source
Puerarin Acts Through Brain Serotonergic Mechanisms to Induce Thermal Effects
Journal of Pharmacological Sciences, 2004 The present study was attempted to investigate the effect of puerarin, an isoflavone compound isolated from Pueraria lobata, on both the basal body temperature and pyrogenic fever in unanesthetized, restrained rats.
Fu-Shin Chueh +3 more
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Food Bioengineering, EarlyView.Synergistic isoflavone‐probiotic action modulated metabolic, microbial and ovarian pathway ABSTRACT Polycystic ovary syndrome (PCOS) is a prevalent metabolic–endocrine disorder characterized by insulin resistance, hyperandrogenism, chronic inflammation, oxidative stress, and ovarian dysfunction, with growing evidence implicating gut microbiota ...
Jeyavelkumaran Renukadevi +4 more
wiley +1 more source
Puerarin Exerts Protective Effects on Wear Particle-Induced Inflammatory Osteolysis
Frontiers in Pharmacology, 2019 Wear particle-stimulated inflammatory bone destruction and the consequent aseptic loosening remain major postoperative problems for artificial joints. Studies have indicated that puerarin promotes osteogenesis and alleviates lipopolysaccharide-induced ...
Chao Yang +6 more
doaj +1 more source
Frontiers in Pharmacology, 2022 Purpose: This study was designed to evaluate the pharmacological mechanisms of puerarin against oliguria in acute alcoholism via network pharmacology analysis combined with experimental verification.Methods: First, this study established an acute ...
Mei-Xuan Wan +5 more
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The Kaohsiung Journal of Medical Sciences, EarlyView.ABSTRACT This study evaluated the effects of puerarin and adipose‐derived stem cells (ADSCs), alone or combined, on p38MAPK activity, alveolar bone preservation, and inflammatory responses in a rat periodontitis (PD) model and in vitro. ADSCs were exposed to various puerarin concentrations to assess cell proliferation, osteogenic differentiation, and ...
Ting Yang, Xu Zhang, Liang‐Fu Zhang
wiley +1 more source
Preparation and Application of Monoclonal Antibody against Puerarin [PDF]
, 2012 葛根为豆科植物野葛或粉葛的干燥根，为常用中药之一，具有解肌退热、生津、透疹、升阳止泻的功效，多用于治疗外感发热、头痛、项强、消渴、麻疹不透、热痢、泄泻、高血压等症状。葛根素(Puerarin，PU)是葛根的主要活性成分，属于黄酮类化合物，药理作用广泛，是一种很有开发前景的药物。 本实验采用杂交瘤技术制备葛根素的单克隆抗体，在此基础上建立葛根素的酶联免疫吸附分析法检测技术，对葛根中药及中成药中葛根素的含量进行检测和评价。 主要的实验结果如下： （1）采用高碘酸钠法合成免疫人工抗原PU ...
吴俊杰
core
Effect of metformin on the spatial memory in aged rats [PDF]
, 2015 Background: Aging process is often accompanied with some degree of decline in all the abilities, including learning and memory. One of the attracting research fields has been devoted to finding antiaging drugs.
Ashrostaghi, Z., Ganji, F., Sepehri, H.
core +1 more source