Results 161 to 170 of about 148,322 (338)

Enhancing Selective Brain Cancer Therapy: Integrating Nanomedicine and Molecular Dynamics to Target the Cancerous Lipid Composition

Nano Select, EarlyView.
Improving selectivity within therapeutic design is critical to ensure targeted delivery to brain tumors. Targeting the cellular membrane composition distinctive of the blood–brain barrier and brain cancer cells is explored in this review. Nanomedicine can be utilized for precise tumor recognition, and detailed mechanistic interactions of therapeutics ...
Mahnoor Kadri, Dominique de Jong‐Hoogland, Martin B. Ulmschneider   +2 more
wiley   +1 more source

Metabolites derived from radical oxidation of PUFA: NEO-PUFAs, promising molecules for health?

Atherosclerosis
Oxidative stress plays a critical role in numerous pathological processes. Under these stress conditions, the free radical-catalyzed lipid peroxidation generates in vivo a large number of key products that are involved in many physiological and pathophysiological processes.
Abramova, Anna, Bride, Jamie, Oger, Camille, Demion, Marie, Galano, Jean-Marie, Durand, Thierry, Roy, Jérôme   +6 more
openaire   +4 more sources

The MetaboHealth Score Enhances Insulin Resistance Metabotyping for Targeted Fat Loss: The PERSON Study

Obesity, EarlyView.
ABSTRACT Objective We previously identified distinct muscle and liver insulin resistance (IR) metabotypes in middle‐aged and older adults. The PERSON study showed that a low‐fat, high‐protein, high‐fiber diet benefits the muscle IR group, while a high‐monounsaturated fatty acid diet benefits the liver IR group. We also developed the MetaboHealth score,
Jordi Morwani‐Mangnani, Fatih A. Bogaards, Alexander Umanets, Gabby B. Hul, Anouk Gijbels, Gijs H. Goossens, Joris Deelen, Marian Beekman, Lydia Afman, Ellen E. Blaak, P. Eline Slagboom   +10 more
wiley   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

PUFAs and IBD [PDF]

Inflammatory Bowel Diseases, 2017
Livia, Lindoso, Suresh, Venkateswaran, Subra, Kugathasan   +2 more
openaire   +2 more sources

An engineered epididymal cell line provides a sustainable source of functional extracellular vesicles for in vitro sperm preservation: A multi‐omics and functional study

VIEW, EarlyView.
ABSTRACT This study investigated the function of epididymal extracellular vesicles (EVs) in overcoming sperm post‐testicular modification deficiencies. Although EVs derived from the epididymis play a crucial role in intercellular communication and molecular exchange, there is limited research addressing how EVs released by in vitro cultured epididymal ...
Long Li, Haonan Zhao, Yibo Li, Qixin Xu, Yang Zi, Tingting Chu, Heran Cao, Shujuan Liu, Zifang Wu, Huanqiang Zhao, Wuzi Dong   +10 more
wiley   +1 more source

Dietary differentiation of two co‐occurring common bat species (Eptesicus nilssonii and Pipistrellus pygmaeus)

Wildlife Biology, EarlyView.
Sympatric bat species can co‐exist and avoid interspecific competition via niche differentiation e.g. diet. Detecting dietary differences can be achieved by comparing dietary niches of sympatric and allopatric populations. If dietary overlap is higher in sympatry versus allopatry, co‐occurrence may be altering the dietary niche of the species.
Heather Wood, Adam Kimberley, William F. Englund, Sara A. O. Cousins   +3 more
wiley   +1 more source

Dietary Omega-3 Polyunsaturated Fatty Acid Deprivation Does Not Alter Seizure Thresholds but May Prevent the Anti-seizure Effects of Injected Docosahexaenoic Acid in Rats. [PDF]

, 2018
Background: Brain concentrations of omega-3 docosahexaenoic acid (DHA, 22:6n-3) have been reported to positively correlate with seizure thresholds in rodent seizure models.
Bazinet, Richard P, Burnham, W McIntyre, Coibanu, Flaviu A, Jeffrey, Melanie A, Saxena, Anjali, Taha, Ameer Y, Taha, Nadeen MY, Trepanier, Marc-Olivier   +7 more
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High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri): From Physiological Phenotypes to AltitudeOmics

Integrative Zoology, EarlyView.
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog (Nanorana parkeri) survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection.
Xuejing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang Chen   +6 more
wiley   +1 more source

The impact of fish oil fatty-acids on post-prandial vascular reactivity. [PDF]

, 2014
Progressive loss of vascular reactivity and increased vascular tone with age are being increasingly recognised as significant cardiovascular disease (CVD) risk factors.
Mcmanus, Sean
core