Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, Volume 7, Issue 2, Page 35-51, June 2026.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
The relationship between the clinical status of permanent first molars in children and dental neglect. [PDF]
BMC Oral HealthGümüşboğa ZŞ +2 more
europepmc +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, Volume 13, Issue 35, 24 June 2026.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
ACSL4 as a context-dependent metabolic switch in hepatocellular carcinoma: implications for ferroptosis and immunotherapy. [PDF]
Front ImmunolLuo Q, Zhang Z.
europepmc +1 more source
The Effects of Untreated Caries on Oral-Health-Related Quality of Life and Body Mass Index in 11-12-Year-Old Children. [PDF]
Acta Stomatol CroatSahin S, Sen Yavuz B, Kargul B.
europepmc +1 more source
Advanced Science, Volume 13, Issue 34, 19 June 2026.This study designs a targeted nanocomposite (ct@HMCF‐Dex) that responds to acidic infection microenvironments, releasing components which amplify oxidative stress. It disrupts bacterial redox balance, chelates metals to sustain lipid peroxidation, and synergistically induces cuproptosis/ferroptosis‐like death.
Zehui Xiao +6 more
wiley +1 more source
Literature-based human milk nutrient composition values for use in North American food composition databases. [PDF]
Am J Clin NutrHopperton KE +13 more
europepmc +1 more source
Advanced Science, Volume 13, Issue 33, 15 June 2026.This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang +9 more
wiley +1 more source
Maternal diet shapes neonatal microbiome ontogenesis and neurometabolic resilience. [PDF]
Gut MicrobesKadyan S +8 more
europepmc +1 more source
Animal Genetics, Volume 57, Issue 3, June 2026.ABSTRACT The intramuscular fat (IMF) content is an important indicator of meat quality, affecting the sensory properties of meat. IMF is a complex trait with polygenic nature. This research aimed to identify differentially expressed (DE) genes and key transcription factors (TFs) associated with IMF deposition in the liver of two rabbit lines ...
Jesús Valdés‐Hernández +4 more
wiley +1 more source