Results 131 to 140 of about 8,097,471 (281)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Erratum to microRNA-221 promotes proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs) by targeting tissue inhibitor of metalloproteinases-3 (TIMP3). [PDF]

Cardiovasc Diagn Ther, 2023
Editorial Office.
europepmc   +1 more source

The investigation of corpus cavernosum smooth muscle dysfunction in low-flow priapism. [PDF]

, 2007
Prolonged low-flow (ischaemic) priapism results in a progressive alteration of the microenvironment within the corpus cavemosum with the development of hypoxia, acidosis and glucopenia and a reduction in the responsiveness to a-adrenergic receptor ...
Muneer, A., Muneer, Asif
core  

NF-κB p65 staining in pulmonary vascular cells in lung parenchyma a patient with idiopathic pulmonary arterial hypertension.

, 2013
Light microscopy demonstrating immunohistochemical p65+ (pink)-staining in vascular cells in diseased pulmonary arteries in lung sections from pulmonary arterial hypertension (PAH) subjects.
Chao Meng (467013), S. John Wort (467022), Mark Griffiths (467021), Gaetano Caramori (338672), Konstantinos Dimopoulos (467017), Barbara Girerd (467018), Ian M. Adcock (133335), Frederic Perros (467012), David Montani (467016), Marc Humbert (23466), Natalia Gambaryan (467014), Alastair Proudfoot (467020), Alberto Papi (347149), Laura C. Price (467011), Dongmin Shao (186047), Paolo Casolari (347143), Sharon Mumby (467019), Peter Dorfmuller (467015), Jie Zhu (126574)   +18 more
core   +1 more source

Renal‐vascular axis: unmasking its role in vascular endothelial growth factor‐inhibitor vascular toxicity in cancer patients

British Journal of Pharmacology, EarlyView.
Abstract Vascular toxicity is a growing concern in cancer patients receiving vascular endothelial growth factor inhibitor (VEGFi) therapy, posing a significant threat to patient prognosis. While the primary mechanism of VEGFi‐induced vascular toxicity is linked to redox‐sensitive reactions that disrupt vascular tone, leading to hypertension and ...
Grace Whelan, Karla B. Neves
wiley   +1 more source

Protocol for quantum dot-based cell counting and immunostaining of pulmonary arterial cells from patients with pulmonary arterial hypertension

STAR Protocols
Summary: Currently, there is no protocol for growing and culturing primary pulmonary arterial cells (PACs) available from the Pulmonary Hypertension Breakthrough Initiative (PHBI).
Sakib M. Moinuddin, Md Ibrahim, Tanoy Sarkar, Md Shahadat Hossain, Melanie Rose, Fakhrul Ahsan   +5 more
doaj   +1 more source

YAP-mediated glycolysis promotes pulmonary arterial smooth muscle cell proliferation in pulmonary arterial hypertension

Journal of Biological Chemistry
Glycolytic shift is implicated in the pathogenesis of pulmonary arterial hypertension (PAH). 6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) has been identified as a key enzyme regulating glycolysis. However, the molecular mechanisms underlying PFKFB3 regulation and glycolysis reprogramming in PAH remain unclear.
Shi, Wenhua, Chen, Liping, Zhang, Wei, He, Ping, Zhang, Yonghong, Yan, Kecheng, Li, Cong, Ning, Pu, Liu, Yuan, Ma, Shuzhen, Ke, Rui   +10 more
openaire   +2 more sources

Role of the soluble epoxide hydrolase and cytochrome P450-derived epoxyeicosatrienoic acids in hypoxic pulmonary vasoconstriction and hypoxia-induced pulmonary vascular remodelling [PDF]

, 2009
Hypoxic pulmonary vasoconstriction (HPV) redistributes pulmonary blood flow from areas of low oxygen partial pressure to areas of normal or relativity high oxygen availability, thus optimising the matching of perfusion to ventilation and preventing ...
Keserü, Benjamin
core  

Cardiotoxicity of BRAF/MEK inhibitors

British Journal of Pharmacology, EarlyView.
Abstract Rapidly accelerated fibrosarcoma type B/B‐Raf proto‐oncogene, serine/threonine kinase (BRAF) and mitogen‐activated protein kinase (MEK) inhibitors have transformed outcomes in cancer therapy, particularly in melanoma. However, cardiovascular toxicities are increasingly recognized in real‐world clinical practice.
Katharina Seuthe, Valerie Lohner, Kevin Terre, Thomas Riffelmacher, Roman Pfister   +4 more
wiley   +1 more source

Antiproliferative effect of selexipag active metabolite MRE-269 on pulmonary arterial smooth muscle cells from patients with chronic thromboembolic pulmonary hypertension. [PDF]

Pulm Circ, 2023
Kuramoto K, Ogawa A, Kiyama K, Matsubara H, Ohno Y, Fuchikami C, Hayashi K, Kosugi K, Kuwano K.   +8 more
europepmc   +1 more source