Results 1 to 10 of about 183,367 (206)

Circular RNA-HIPK3 regulates human pulmonary artery endothelial cells function and vessel growth by regulating microRNA-328-3p/STAT3 axis [PDF]

Pulmonary Circulation, 2021
The proliferation and migration of pulmonary artery endothelial cells are the pathological basis of pulmonary vascular remodeling with pulmonary hypertension. Recent studies have shown that circular RNA (circRNA) regulates biological processes in various
Liuqing Hong, Xiaoying Ma, Jiyuan Liu, Yinzhu Luo, Jincai Lin, Ying Shen, Liyan Zhang   +6 more
doaj   +3 more sources

Single-cell transcriptomic profile of human pulmonary artery endothelial cells in health and pulmonary arterial hypertension. [PDF]

Sci Rep, 2021
Pulmonary arterial hypertension (PAH) is an insidious disease characterized by severe remodeling of the pulmonary vasculature caused in part by pathologic changes of endothelial cell functions.
Asosingh K, Comhair S, Mavrakis L, Xu W, Horton D, Taylor I, Tkachenko S, Hu B, Erzurum S.   +8 more
europepmc   +2 more sources

Endothelial cell processing and alternatively spliced transcripts of factor VIII: potential implications for coagulation cascades and pulmonary hypertension. [PDF]

PLoS ONE, 2010
Coagulation factor VIII (FVIII) deficiency leads to haemophilia A. Conversely, elevated plasma levels are a strong predictor of recurrent venous thromboemboli and pulmonary hypertension phenotypes in which in situ thromboses are implicated.
Claire L Shovlin, Gillian Angus, Richard A Manning, Grace N Okoli, Fatima S Govani, Kay Elderfield, Graeme M Birdsey, Inês G Mollet, Michael A Laffan, Francesco A Mauri   +9 more
doaj   +4 more sources

Transcriptional profiles of pulmonary artery endothelial cells in pulmonary hypertension [PDF]

Scientific Reports, 2023
Pulmonary arterial hypertension (PAH) is characterized by endothelial cell (EC) dysfunction. There are no data from living patients to inform whether differential gene expression of pulmonary artery ECs (PAECs) can discern disease subtypes, progression ...
Navneet Singh, Carsten Eickhoff, Augusto Garcia-Agundez, Paul Bertone, Sunita S. Paudel, Dhananjay T. Tambe, Leslie A. Litzky, Katherine Cox-Flaherty, James R. Klinger, Sean F. Monaghan, Christopher J. Mullin, Mandy Pereira, Thomas Walsh, Mary Whittenhall, Troy Stevens, Elizabeth O. Harrington, Corey E. Ventetuolo   +16 more
doaj   +2 more sources

Sex differences in the proliferation of pulmonary artery endothelial cells: implications for plexiform arteriopathy.

J Cell Sci, 2020
The sex-biased disease pulmonary arterial hypertension (PAH) is characterized by the proliferation and overgrowth of dysfunctional pulmonary artery endothelial cells (PAECs).
Qin S, Predescu DN, Patel M, Drazkowski P, Ganesh B, Predescu SA.   +5 more
europepmc   +2 more sources

Human pulmonary artery endothelial cells upregulate ACE2 expression in response to iron‐regulatory elements: Potential implications for SARS‐CoV‐2 infection [PDF]

Pulmonary Circulation, 2022
Vascular endothelial cell dysfunction is reported in severe coronavirus disease 2019 disease, however, controversy exists regarding levels of angiotensin‐converting enzyme 2 (ACE2) expression, a coreceptor for severe acute respiratory syndrome ...
Quezia K. Toe, Theo Issitt, Abdul Mahomed, Fatma Almaghlougth, Ishan Bahree, Charles Sturge, Xueqi Hu, Ioannis Panselinas, Anne Burke‐Gaffney, Stephen, Jc Wort, Gregory John Quinlan   +10 more
doaj   +2 more sources

Pulmonary endothelial cells from different vascular segments exhibit unique recovery from acidification and Na+/H+ exchanger isoform expression

PLoS ONE, 2022
Sodium-hydrogen exchangers (NHEs) tightly regulate intracellular pH (pHi), proliferation, migration and cell volume. Heterogeneity exists between pulmonary endothelial cells derived from different vascular segments, yet the activity and isoform ...
Dylan Adams, Chung-Sik Choi, Sarah L. Sayner   +2 more
doaj   +2 more sources

Double-Stranded RNA Attenuates the Barrier Function of Human Pulmonary Artery Endothelial Cells [PDF]

, 2013
Circulating RNA may result from excessive cell damage or acute viral infection and can interact with vascular endothelial cells. Despite the obvious clinical implications associated with the presence of circulating RNA, its pathological effects on ...
A Shibamiya, A Siflinger-Birnboim, AA Birukova, AK Cardozo, Akos Heinemann, AM Lundberg, Andrea Olschewski, Attila G. Végh, B Nilius, BE Dewi, BL Jacobs, C Caspersen, C Kannemeier, C Tiruppathi, Chandran Nagaraj, Csilla Fazakas, D Torres, Diana Zabini, ET Chiang, F Aeffner, G Grynkiewicz, GM Cheng, GU Ahmmed, György Váró, Horst Olschewski, HT Ma, I Khan, I Wilhelm, Imola Wilhelm, István A. Krizbai, J Tissari, JL Harcourt, L Fischer, L Liu, M Auer-Grumbach, M Schroder, MM Szewczyk, N Pirher, NC Stowell, O Dellis, P Kumar, PR Cooper, R Malli, R Malli, R O’Callaghan, R Ross, R Sutliff, Rory Edward Morty, S Akira, S Fischer, S Fischer, S Sarkar, S Zimmer, TG Ksiazek, TM Moore, V Konya, VA Londhe, Viktoria Konya, Y Tsuji, Z Balint, Zoltán Bálint   +60 more
core   +10 more sources

Nanoparticle endothelial delivery of PGC-1α attenuates hypoxia-induced pulmonary hypertension by attenuating EndoMT-caused vascular wall remodeling

Redox Biology, 2022
Pulmonary hypertension (PH) induced by chronic hypoxia is characterized by thickening of pulmonary artery walls, elevated pulmonary vascular resistance, and right-heart failure. Dysfunction of endothelial cells is the hallmark event in the progression of
Dunpeng Cai, Shi-You Chen
doaj   +1 more source

Extracellular matrix degradation pathways and fatty acid metabolism regulate distinct pulmonary vascular cell types in pulmonary arterial hypertension

Pulmonary Circulation, 2021
Pulmonary arterial hypertension describes a group of diseases characterised by raised pulmonary vascular resistance, resulting from vascular remodelling in the pre-capillary resistance arterioles.
Sharon Mumby, F. Perros, C. Hui, B.L. Xu, W. Xu, V Elyasigomari, A. Hautefort, G. Manaud, M. Humbert, K.F. Chung, S.J. Wort, I.M. Adcock   +11 more
doaj   +1 more source