Results 161 to 170 of about 183,516 (347)

Hypoxia-Induced Mitochondrial ROS and Function in Pulmonary Arterial Endothelial Cells

Cells
Pulmonary artery endothelial cells (PAECs) are a major contributor to hypoxic pulmonary hypertension (PH) due to the possible roles of reactive oxygen species (ROS).
Harrison Wang, Teng-Yao Song, Jorge Reyes-García, Yong-Xiao Wang   +3 more
doaj   +1 more source

Hypoxia Upregulates NOTCH3 Signaling Pathway to Promote Endothelial-Mesenchymal Transition in Pulmonary Artery Endothelial Cells. [PDF]

Evid Based Complement Alternat Med, 2021
Wang LL, Zhu XL, Han SH, Xu L.
europepmc   +1 more source

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Harnessing nanomaterials to precisely regulate the immunosuppressive tumor microenvironment for enhanced immunotherapy

BMEMat, EarlyView.
The immunosuppressive tumor microenvironment, characterized by hypoxia, redox imbalance, elevated interstitial fluid pressure, and acidity, was comprehensively elucidated. This review discussed the etiology and consequences of the characteristics of the immunosuppressive tumor microenvironment, and analyzed the recent advancements in nanomaterials for ...
Wen Zhang, Xueyin Hu, Wei Cheng, Lumeng Zhang, Yuanfang Chen, Qinrui Fu, Luntao Liu, Saijun Fan   +7 more
wiley   +1 more source

PPARγ/ETV2 axis regulates endothelial‐to‐mesenchymal transition in pulmonary hypertension

Pulmonary Circulation
Endothelial‐to‐mesenchymal transition (EndoMT) plays an important role in pulmonary hypertension (PH) but the molecular mechanisms regulating EndoMT remain to be defined.
Dong Hun Lee, Minseong Kim, Sarah S. Chang, Raham Lee, Andrew J. Jang, Juyoung Kim, Jing Ma, Michael J. Passineau, Raymond L. Benza, Harry Karmouty‐Quintana, Wilbur A. Lam, Benjamin T. Kopp, Roy L. Sutliff, C. Michael Hart, Changwon Park, Bum‐Yong Kang   +15 more
doaj   +1 more source

Growth Differentiation Factor 11 Promotes Abnormal Proliferation and Angiogenesis of Pulmonary Artery Endothelial Cells

HYPERTENSION, 2018
Xiufeng Yu, Xinxin Chen, Xiaodong Zheng, Junting Zhang, Xijuan Zhao, Y. Liu, Hongyue Zhang, Lixin Zhang, Hao-tong Yu, Min Zhang, Cui Ma, Xuewei Hao, Daling Zhu   +12 more
semanticscholar   +1 more source

Contemporary and Emerging Therapies in the Management of Refractory Angina: A Clinical Review

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Refractory angina (RA) represents a growing challenge in clinical cardiology, particularly in patients with obstructive coronary artery disease (CAD) who remain symptomatic despite optimal medical therapy and who are not candidates for revascularization.
Alex Angers‐Goulet, Siddhartha Mengi, David Garcia Labbé, Can Manh Nguyen, Jean‐Michel Paradis   +4 more
wiley   +1 more source

Author Correction: Single-cell transcriptomic profile of human pulmonary artery endothelial cells in health and pulmonary arterial hypertension. [PDF]

Sci Rep, 2021
Asosingh K, Comhair S, Mavrakis L, Xu W, Horton D, Taylor I, Tkachenko S, Hu B, Erzurum S.   +8 more
europepmc   +1 more source

Lung Circulation Modeling: Status and Prospect [PDF]

, 2006
Mathematical modeling has been used to interpret anatomical and physiological data obtained from metabolic and hemodynamic studies aimed at investigating structure-function relationships in the vasculature of the lung, and how these relationships are ...
Audi, Said H., Clough, Anne V., Krenz, Gary S., Molthen, Robert C.   +3 more
core   +1 more source

12-Lipoxygenase and 12-hydroxyeicosatetraenoic acid regulate hypoxic angiogenesis and survival of pulmonary artery endothelial cells via PI3K/Akt pathway.

American Journal of Physiology - Lung cellular and Molecular Physiology, 2018
Chen Zhang, Cui Ma, Hongmin Yao, Lixin Zhang, Xiufeng Yu, Yumei Liu, Tingting Shen, Linlin Zhang, Fengying Zhang, Xinxin Chen, Daling Zhu   +10 more
semanticscholar   +1 more source