Results 11 to 20 of about 183,516 (347)

Caspase-4/11–Mediated Pulmonary Artery Endothelial Cell Pyroptosis Contributes to Pulmonary Arterial Hypertension

Hypertension, 2022
Supplemental Digital Content is available in the text. Background: Endothelial dysfunction enhances vascular inflammation, which initiates pulmonary arterial hypertension (PAH) pathogenesis, further induces vascular remodeling and right ventricular ...
Yusi Wu, Bingjie Pan, Zhen Zhang, Xiao-hui Li, Yiping Leng, Yong Ji, Kun Sun, Alex F. Chen   +7 more
semanticscholar   +3 more sources

Alterations of cellular bioenergetics in pulmonary artery endothelial cells [PDF]

Proceedings of the National Academy of Sciences, 2007
Idiopathic pulmonary arterial hypertension (IPAH) is pathogenetically related to low levels of the vasodilator nitric oxide (NO). Because NO regulates cellular respiration and mitochondrial biogenesis, we hypothesized that abnormalities of bioenergetics may be present in IPAH.
Weiling Xu, T. Koeck, Abigail R. Lara, D. Neumann, F. Difilippo, M. Koo, A. Janocha, F. Masri, A. Arroliga, Constance Jennings, R. Dweik, R. Tuder, D. Stuehr, S. Erzurum   +13 more
semanticscholar   +3 more sources

Pulmonary Artery Endothelium Resident Endothelial Colony‐Forming Cells in Pulmonary Arterial Hypertension [PDF]

Pulmonary Circulation, 2011
Proliferative pulmonary vascular remodeling is the pathologic hallmark of pulmonary arterial hypertension (PAH) that ultimately leads to right heart failure and death. Highly proliferative endothelial cells known as endothelial colony‐forming cells (ECFC) participate in vascular homeostasis in health as well as in pathological angiogenic remodeling in ...
Duong, Heng T., Comhair, Suzy A., Aldred, Micheala A., Mavrakis, Lori, Savasky, Benjamin M., Erzurum, Serpil C., Asosingh, Kewal   +6 more
openaire   +2 more sources

Culture of pulmonary artery endothelial cells from pulmonary artery catheter balloon tips: considerations for use in pulmonary vascular disease

European Respiratory Journal, 2020
Endothelial dysfunction is a hallmark of pulmonary arterial hypertension (PAH) but there are no established methods to study pulmonary artery endothelial cells (PAECs) from living patients.
C. Ventetuolo, J. Aliotta, J. Braza, H. Chichger, M. Dooner, Donald McGuirl, C. Mullin, J. Newton, M. Pereira, A. Princiotto, P. Quesenberry, Thomas Walsh, M. Whittenhall, J. Klinger, E. Harrington   +14 more
semanticscholar   +1 more source

Extracellular vesicles derived from endothelial cells in hypoxia contribute to pulmonary artery smooth muscle cell proliferation in‐vitro and pulmonary hypertension in mice

Pulmonary Circulation, 2021
In the lung, communication between pulmonary vascular endothelial cells (PVEC) and pulmonary artery smooth muscle cells (PASMC) is essential for the maintenance of vascular homeostasis.
Tianji Chen, Miranda R. Sun, Qiyuan Zhou, A. Guzman, R. Ramchandran, Jiwang Chen, B. Ganesh, J. Raj   +7 more
semanticscholar   +1 more source

Reversal of Hypoxic Pulmonary Hypertension by Hypoxia-Inducible Overexpression of Angiotensin-(1-7) in Pulmonary Endothelial Cells

Molecular Therapy: Methods & Clinical Development, 2020
Hypoxia-induced pulmonary vascular constriction and structure remodeling are the main causes of hypoxic pulmonary hypertension. In the present study, an adeno-associated virus vector, containing Tie2 promoter and hypoxia response elements, was designed ...
Man-Ling Liu, Shu-Juan Xing, Xiao-Qing Liang, Ying Luo, Bo Zhang, Zhi-Chao Li, Ming-Qing Dong   +6 more
doaj   +1 more source

ITE inhibits growth of human pulmonary artery endothelial cells. [PDF]

Exp Lung Res, 2017
Pulmonary arterial hypertension (PAH), a deadly disorder is associated with excessive growth of human pulmonary artery endothelial (HPAECs) and smooth muscle (HPASMCs) cells. Current therapies primarily aim at promoting vasodilation, which only ameliorates clinical symptoms without a cure.
Pang LP, Li Y, Zou QY, Zhou C, Lei W, Zheng J, Huang SA.   +6 more
europepmc   +4 more sources

Locational memory of macrovessel vascular cells is transcriptionally imprinted

Scientific Reports, 2023
Vascular pathologies show locational predisposition throughout the body; further insights into the transcriptomics basis of this vascular heterogeneity are needed.
Talitha C. F. Spanjersberg, Loes A. Oosterhoff, Hedwig S. Kruitwagen, Noortje A. M. van den Dungen, Johannes C. M. Vernooij, Folkert W. Asselbergs, Michal Mokry, Bart Spee, Magdalena Harakalova, Frank G. van Steenbeek   +9 more
doaj   +1 more source

Pulmonary Artery Endothelial Cells [PDF]

, 2003
Endothelial cells function as a highly regulated barrier between blood and interstitium. They play a central role in the regulation of vascular permeability by controlling the passage of liquid and nutrients as well as the transit of white blood cells (1,2).
J, Seybold, N, Suttorp
openaire   +2 more sources

HIV Nef Protein Causes Endothelial Dysfunction in Porcine Pulmonary Arteries and Human Pulmonary Artery Endothelial Cells [PDF]

Journal of Surgical Research, 2009
Infection of human immunodeficiency virus (HIV) has been associated with several chronic diseases, including pulmonary artery hypertension and atherosclerosis. However, the underlying mechanisms of these vascular complications are largely unknown. The objective of this study was to test a novel hypothesis that HIV Nef, an accessory HIV protein, may ...
Patrick, Duffy, Xinwen, Wang, Peter H, Lin, Qizhi, Yao, Changyi, Chen   +4 more
openaire   +2 more sources