Results 261 to 270 of about 183,516 (347)

Refractory Peripheral Pulmonary Stenosis and Severe Pulmonary Arterial Hypertension Associated With a <i>De Novo</i> Loss-of-Function Variant in <i>FGD5</i>. [PDF]

Pulm Circ
Steffes LC, Adamson GT, Dunn KE, Feinstein JA.   +3 more
europepmc   +1 more source

The Role of Brain Structure in Explaining Physical Functioning in Male Veterans With Impaired Kidney Function

Journal of the American Geriatrics Society, EarlyView.
Brain structure as a mediator of the relationship of impaired kidney function and physical function. ABSTRACT Background Older adults with chronic kidney disease (CKD) experience deficits in physical function and cardiorespiratory fitness at higher rates than older adults without impaired renal function.
Julie S. Rekant, Hinza B. Malik, Jamie E. Giffuni, Shari R. Waldstein, Kelly P. Westlake, Christos Davatzikos, Guray Erus, Stephen L. Seliger   +7 more
wiley   +1 more source

Transmembrane Protein 100 Expression on Endothelial Cells Vascularizing Thrombi in Chronic Thromboembolic Pulmonary Hypertension Modulates TGFβ1-ALK1 Signaling During Angiogenesis. [PDF]

Pulm Circ
Bochenek ML, Ghasemi I, Wiedenroth CB, Bikou O, Karampinis I, Roessner ED, Hobohm L, Guth S, Lurz P, Konstantinides S, Schäfer K.   +10 more
europepmc   +1 more source

The “Reducing Inflammation for Greater Health Trial (RIGHT)” Study—Concept, Rationale, and Design

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT The Reducing Inflammation for Greater Health Trial's (RIGHT) study is a single‐center, randomized, double‐blind, placebo‐controlled trial designed to test whether clazkizumab, an interleukin‐6 (IL‐6) inhibitor, can improve or slow decline in physical, cognitive, and vascular function in older adults, when compared to a placebo.
Sebastian E. Sattui, Marnie Bertolet, Daniel E. Forman, Michelle E. Danielson, Shanshan Yao, Oscar L. Lopez, Nancy W. Glynn, Neelesh K. Nadkarni, Akira Sekikawa, Tullia C. Bruno, Toren Finkel, Anne B. Newman   +11 more
wiley   +1 more source

Cyclin‐dependent kinase 13 is indispensable for normal mouse heart development

Journal of Anatomy, Volume 246, Issue 4, Page 616-630, April 2025.
Congenital heart disease (CHD) is the most common defect in live births. The role of cyclin‐dependent kinase (CDK13) in cardiogenesis and CHD was studied using a transgenic mouse model (Cdk13tm1b) carrying deletion of exons 3 and 4, causing loss of function.
Qazi Waheed‐Ullah, Anna Wilsdon, Aseel Abbad, Sophie Rochette, Frances Bu'Lock, Asma Ali Saed, Marc‐Phillip Hitz, J. David Brook, Siobhan Loughna   +8 more
wiley   +1 more source

ADAR1-Mediated RNA Editing Regulates Innate Immunity in Pulmonary Hypertension. [PDF]

Circ Res
Shen Y, Bisserier M.
europepmc   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Porphyromonas gingivalis GroEL exacerbates orthotopic allograft transplantation vasculopathy via impairment of endothelial cell function

Molecular Oral Microbiology, EarlyView.
Abstract Orthotopic allograft transplantation (OAT) is a significant approach to addressing organ failure. However, persistent immune responses to the allograft affect chronic rejection, which induces OAT vasculopathy (OATV) and organ failure. Porphyromonas gingivalis can infiltrate remote organs via the bloodstream, thereby intensifying the severity ...
Chien‐Sung Tsai, Chun‐Yao Huang, Yi‐Ting Tsai, Chun‐Ming Shih, Ze‐Hao Lai, Chen‐Wei Liu, Yi‐Wen Lin, Feng‐Yen Lin   +7 more
wiley   +1 more source

The P4HA1/HIF1α feedback loop modulates endothelial dysfunction in pulmonary hypertension. [PDF]

Respir Res
Chen Y, Lv Y, Yang M, Qian Z, Jiang X, Jiang Z, Kong C, Gu Y, Deng Y, Chen SL.   +9 more
europepmc   +1 more source

Long Non-Coding RNA MALAT1 Regulates HMOX1 in Sickle Cell Disease-Associated Pulmonary Hypertension. [PDF]

Cells
Sueblinvong V, Chang SS, Ma J, Archer DR, Ofori-Acquah S, Sutliff RL, Park C, Hart CM, Kopp BT, Kang BY.   +9 more
europepmc   +1 more source