Results 21 to 30 of about 183,516 (347)
IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis
Respiratory Research, 2022 Background Pulmonary hypertension (PH) associated to idiopathic pulmonary fibrosis (IPF) portends a poor prognosis. IL-11 has been implicated in fibrotic diseases, but their role on pulmonary vessels is unknown. Here we analyzed the contribution of IL-11
Javier Milara +5 more
doaj +1 more source
Respiratory Research, 2022 Background Despite causing increased morbidity and mortality, pulmonary hypertension (PH) in chronic obstructive pulmonary disease (COPD) patients (COPD-PH) lacks treatment, due to incomplete understanding of its pathogenesis.
Khushboo Goel +11 more
doaj +1 more source
PLoS ONE, 2020 Pulmonary hypertension is a progressive lung disease with poor prognosis due to the consequent right heart ventricular failure. Pulmonary artery remodeling and dysfunction are culprits for pathologically increased pulmonary arterial pressure, but their ...
Pranindya Rinastiti +7 more
doaj +1 more source
NETs Activate Pulmonary Arterial Endothelial Cells [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2016 The article by Aldabbous et al1 describes neutrophil extracellular traps (NETs) as a novel feature related to the vascular pathology of both pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). NETs were originally identified as a suicide mechanism whereby neutrophil elastase degrades and releases chromatin ...
openaire +2 more sources
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017 BackgroundMonocrotaline has been widely used to establish an animal model of pulmonary hypertension. The molecular target underlying monocrotaline‐induced pulmonary artery endothelial injury and pulmonary hypertension remains unknown.
Rui Xiao +10 more
doaj +1 more source
Biomolecules & Biomedicine, 2014 The objective of our work was to investigate the influence of Fasudil, a Rho inhibitor on the number and function of the late endothelial progenitor cells in peripheral blood of chronic obstructive pulmonary diseases (COPD) patients with pulmonary ...
Pei Liu +5 more
doaj +1 more source
Platelet kinetics in the pulmonary microcirculation in vivo assessed by intravital microscopy [PDF]
, 2002 Growing evidence supports the substantial pathophysiological impact of platelets on the development of acute lung injury. Methods for studying these cellular mechanisms in vivo are not present yet.
Eichhorn, M. E. +3 more
core +1 more source
Hypoxia Preconditioning Increases Survival and Decreases Expression of Toll-like Receptor 4 in Pulmonary Artery Endothelial Cells Exposed to Lipopolysaccharide [PDF]
, 2013 Pulmonary or systemic infections and hypoxemic respiratory failure are among the leading causes of admission to intensive care units, and these conditions frequently exist in sequence or in tandem.
Ali, Irshad +7 more
core +2 more sources
Senescence Alterations in Pulmonary Hypertension
Cells, 2021 Cellular senescence is the arrest of normal cell division and is commonly associated with aging. The interest in the role of cellular senescence in lung diseases derives from the observation of markers of senescence in chronic obstructive pulmonary ...
Inés Roger +3 more
doaj +1 more source
Pneumolysin activates phospholipase A in pulmonary artery endothelial cells [PDF]
Infection and Immunity, 1994 Pneumolysin has been identified as a virulence factor in Streptococcus pneumoniae disease. In addition to producing tissue injury through its cytolytic effect, pneumolysin might injure tissues indirectly by eliciting an inflammatory response. We demonstrate for the first time that pneumolysin is a rapid and potent activator of cellular phospholipase A ...
J B, Rubins +3 more
openaire +2 more sources