Results 291 to 300 of about 183,516 (347)
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Elastin production by cultured calf pulmonary artery endothelial cells
Journal of Cellular Physiology, 1983AbstractCalf pulmonary artery (CPA) endothelial cells synthesize and secrete soluble elastin when incubated in medium conditioned by arterial smooth muscle cells. Endothelial cell tropoelastin cross‐reacts with antiserum to bovine ligamentum nuchae elastin and comigrates on SDS‐PAGE with tropoelastins from fetal bovine ligamentum nuchae fibroblasts ...
R P, Mecham +3 more
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Panorama of artery endothelial cell dysfunction in pulmonary arterial hypertension
Journal of Molecular and Cellular CardiologyPulmonary arterial hypertension (PAH) is a fatal lung disease characterized by progressive pulmonary vascular remodeling. The initial cause of pulmonary vascular remodeling is the dysfunction of pulmonary arterial endothelial cells (PAECs), manifested by changes in the categorization of cell subtypes, endothelial programmed cell death, such as ...
Ying-Huizi, Shen +7 more
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Hypoxia inhibits L-arginine uptake by pulmonary artery endothelial cells.
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1995Under physiological conditions, L-arginine transport by porcine pulmonary artery endothelial cells (PAEC) is mediated by system y+, a sodium-independent transport system that accounts for 60 +/- 5% of L-arginine transport, and system Bo,+, a sodium-dependent system that accounts for 40 +/- 5% of transport.
E. Block, H. Herrera, M. Couch
semanticscholar +3 more sources
Angiotensin receptors in pulmonary arterial and aortic endothelial cells
American Journal of Physiology-Cell Physiology, 1989Angiotensin II (ANG II) is formed from angiotensin I by the action of angiotensin-converting enzyme located on the luminal surface of vascular endothelial cells. We determined whether binding sites specific for ANG II exist on pulmonary artery and aortic endothelial cells. The binding of 125I-ANG II to pulmonary artery and aortic endothelial cells was
J M, Patel +3 more
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Monocrotaline Pyrrole Induces Apoptosis in Pulmonary Artery Endothelial Cells
Toxicology and Applied Pharmacology, 1998In the monocrotaline (MCT) model of pulmonary hypertension, the pulmonary vascular endothelium is the likely early target of the reactive metabolite monocrotaline pyrrole (MCTP). Incubation of cultured bovine pulmonary arterial endothelial cells (BPAEC) with MCTP results in covalent binding to DNA, cell cycle arrest, and delayed but progressive cell ...
H C, Thomas +4 more
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Acrolein-Induced Injury to Cultured Pulmonary Artery Endothelial Cells
Toxicology and Applied Pharmacology, 1993We evaluated the specific effects of acrolein on sulfhydryl status and plasma membrane-dependent functions of cultured pulmonary artery endothelial cells. Acrolein exposure caused a dose-dependent increase in lactate dehydrogenase (LDH) release and decreases in reduced glutathione (GSH) and protein sulfhydryl (P-SH) content, whereas oxidized ...
J M, Patel, E R, Block
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5-Lipoxygenase and human pulmonary artery endothelial cell proliferation
American Journal of Physiology-Heart and Circulatory Physiology, 2002Increased 5-lipoxygenase (5LO) expression in pulmonary artery endothelial cells (PAECs) has been observed in primary pulmonary hypertension, a disorder associated with pulmonary vascular remodeling and aberrant endothelial cell proliferation. To examine whether 5LO plays a role in endothelial cell proliferation, we analyzed the effect of 5LO inhibitors
Jennifer L, Walker +2 more
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4.3 Pulmonary Circulation and Pulmonary Vascular Diseases, 2016
Roundabout (Robo) receptors 1 and 4 and their ligand Slit2, are novel regulators of endothelial cell (EC) function. Robo1/4 can have co-operative and/or opposing effects on cell function. Expression levels vary between EC and it is likely that functional consequences of Slit2 are determined by the predominant Robo receptor.
Zacharoula Nikolakopoulou +4 more
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Roundabout (Robo) receptors 1 and 4 and their ligand Slit2, are novel regulators of endothelial cell (EC) function. Robo1/4 can have co-operative and/or opposing effects on cell function. Expression levels vary between EC and it is likely that functional consequences of Slit2 are determined by the predominant Robo receptor.
Zacharoula Nikolakopoulou +4 more
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Characterization of L-arginine transport by pulmonary artery endothelial cells.
American Journal of Physiology-Lung Cellular and Molecular Physiology, 1991The transport of L-arginine by porcine pulmonary artery endothelial cells (PAECs) was characterized. Uptake of 50 microM L-arginine was time dependent and linear in the presence and absence of sodium, with approximately 70% of uptake occurring via a carrier-mediated Na(+)-independent process.
B. Greene, A. J. Pacitti, W. Souba
semanticscholar +3 more sources
Zinc-related metallothionein metabolism in bovine pulmonary artery endothelial cells
The Journal of Nutritional Biochemistry, 1999Bovine pulmonary artery endothelial cells (BPAEC) were cultured in vitro under a variety of conditions to investigate how metallothionein (MT) might participate in zinc homeostasis. Experimental conditions included 10% serum to ensure that the in vitro environment would be a better reflection of the in vivo situation than with protein-free medium.
D J, Bobilya +4 more
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