Results 31 to 40 of about 183,516 (347)

Novel signaling pathways in pulmonary arterial hypertension (2015 Grover Conference Series) [PDF]

, 2016
The proliferative endothelial and smooth muscle cell phenotype, inflammation, and pulmonary vascular remodeling are prominent features of pulmonary arterial hypertension (PAH).
Awad, Keytam S., de Jesus Perez, Vinicio, MacLean, Margaret, West, James D.   +3 more
core   +1 more source

Galectin-3- Mediated Transdifferentiation of Pulmonary Artery Endothelial Cells Contributes to Hypoxic Pulmonary Vascular Remodeling

Cellular Physiology and Biochemistry, 2018
Background/Aims: Vascular muscularity is a key event in vessel remodeling during pulmonary artery hypertension (PAH). Endothelial-mesenchymal transdifferentiation (EndMT) has been increasingly reported to play a role in disease occurrence.
Li Zhang, Yu-mei Li, Xi-xi Zeng, Xiaoyan Wang, Shao-kun Chen, Long-Xin Gui, Mo-Jun Lin   +6 more
semanticscholar   +1 more source

Pulmonary endothelial cell DNA methylation signature in pulmonary arterial hypertension

Oncotarget, 2017
Pulmonary arterial hypertension (PAH) is a severe and incurable pulmonary vascular disease. One of the primary origins of PAH is pulmonary endothelial dysfunction leading to vasoconstriction, aberrant angiogenesis and smooth muscle cell proliferation, endothelial-to-mesenchymal transition, thrombosis and inflammation.
Hautefort, Aurélie, Chesné, Julie, Preussner, Jens, Pullamsetti, Soni, Tost, Jörg, Looso, Mario, Antigny, Fabrice, Girerd, Barbara, Riou, Marianne, Eddahibi, Saadia, Deleuze, Jean-François, Seeger, Werner, Fadel, Elie, Simonneau, Gerald, Montani, David, Humbert, Marc, Perros, Frédéric   +16 more
openaire   +6 more sources

Endothelial Progenitor Cell-Based Therapy for Pulmonary Arterial Hypertension [PDF]

Cell Transplantation, 2013
A growing body of evidence in animal models and clinical studies supports the concept that endothelial progenitor cell (EPC)-mediated therapy ameliorates pulmonary arterial hypertension (PAH) and thus may represent a novel approach to treat it. Conversely, several experimental findings suggest that EPCs may be involved in PAH pathogenesis and disease ...
Jin-Xiu Yang, Yan-Yun Pan, You-Yang Zhao, Xing-Xiang Wang   +3 more
openaire   +3 more sources

Circulating microparticles in severe pulmonary arterial hypertension increase intercellular adhesion molecule-1 expression selectively in pulmonary artery endothelium

Respiratory Research, 2016
Background Microparticles (MPs) stimulate inflammatory adhesion molecule expression in systemic vascular diseases, however it is unknown whether circulating MPs stimulate localized ICAM-1 expression in the heterogeneically distinct pulmonary endothelium ...
Leslie A. Blair, April K. Haven, Natalie N. Bauer   +2 more
doaj   +1 more source

Role of noncoding RNA in vascular remodelling [PDF]

, 2016
Purpose of review: Noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) are becoming fundamentally important in the pathophysiology relating to injury-induced vascular remodelling.
Baker, Andrew H., Bradshaw, Angela C., Deng, Lin   +2 more
core   +1 more source

Oxidative Stress and Antioxidant Therapy in Pulmonary Hypertension

Antioxidants, 2023
Pulmonary hypertension (PH) is a progressive disease characterized by elevated artery pressures and pulmonary vascular resistance. Underlying mechanisms comprise endothelial dysfunction, pulmonary artery remodeling and vasoconstriction.
Paula Poyatos, Miquel Gratacós, Kay Samuel, Ramon Orriols, Olga Tura-Ceide   +4 more
doaj   +1 more source

Sex-dependent influence of endogenous estrogen in pulmonary hypertension [PDF]

, 2014
Rationale: The incidence of pulmonary arterial hypertension (PAH) is greater in women suggesting estrogens may play a role in the disease pathogenesis. Experimentally, in males exogenously administered estrogen can protect against PH; however in models ...
Audrey F. Wright, David J. Rowlands, Dukes M, Girerd B, Josephine Fullerton, Kirsty M. Mair, Lynn Loughlin, Margaret Nilsen, Margaret R. MacLean, Martin J. Hussey, Matthew Thomas, Muxfeldt ES, Nicholas Duggan, Popovic RM, Silber DH, Sonia Roberts, Takahashi H, Teichmann J   +17 more
core   +1 more source

A20 deficiency leads to angiogenesis of pulmonary artery endothelial cells through stronger NF‐κB activation under hypoxia

Journal of Cellular and Molecular Medicine, 2016
A20 is a zinc finger protein associated with hypoxia. As chronic hypoxia is responsible for intimal hyperplasia and disordered angiogenesis of pulmonary artery, which are histological hallmarks of pulmonary artery hypertension, we intended to explore the
Jing Li, Linlin Zhang, Yueming Zhang, Y. Liu, Hongyue Zhang, Liuping Wei, Tingting Shen, Chun Jiang, Daling Zhu   +8 more
semanticscholar   +1 more source

Ovine carotid artery-derived cells as an optimized supportive cell layer in 2-D capillary network assays. [PDF]

PLoS ONE, 2014
Endothelial cell co-culture assays are differentiation assays which simulate the formation of capillary-like tubules with the aid of a supportive cell layer.
Stefan Weinandy, Patrick Babczyk, Agnieszka Dreier, Ronald E Unger, Thomas C Flanagan, C James Kirkpatrick, Martin Zenke, Doris Klee, Stefan Jockenhoevel   +8 more
doaj   +1 more source