Results 61 to 70 of about 183,516 (347)

The Soybean Isoflavonoid Equol Blocks Ritonavir-Induced Endothelial Dysfunction in Porcine Pulmonary Arteries and Human Pulmonary Artery Endothelial Cells [PDF]

The Journal of Nutrition, 2010
HIV protease inhibitor (PI) ritonavir (RTV) may cause vascular injury through oxidative stress. Our purpose in this study was to determine whether equol, a soy isoflavone, could prevent RTV-induced endothelial dysfunction in porcine pulmonary arteries and in human pulmonary artery endothelial cells (HPAEC).
Charlie, Cheng, Xinwen, Wang, Sarah M, Weakley, Panagiotis, Kougias, Peter H, Lin, Qizhi, Yao, Changyi, Chen   +6 more
openaire   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Up-regulation of Tissue Factor in Human Pulmonary Artery Endothelial Cells after Ultrafine Particle Exposure

Environmental Health Perspectives, 2007
Background Epidemiology studies have linked exposure to pollutant particles to increased cardiovascular mortality and morbidity, but the mechanisms remain unknown.
Edward D. Karoly, Zhuowei Li, L. Dailey, Xhevahire Hyseni, Y. Huang   +4 more
semanticscholar   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Targeting endothelial cells: the pathological mechanisms and therapeutic innovations in pulmonary arterial hypertension

Frontiers in Cell and Developmental Biology
Pulmonary arterial hypertension (PAH) is a fatal disease with high mortality, which is characterized by pulmonary vascular remodeling. Current clinical treatments mainly focus on dilating vascular and relieving pulmonary artery pressure.
Tianfei Fan, Longji Li, Yao Wang, Meng Lin, Fengbo Wu   +4 more
doaj   +1 more source

Circulating Plasma miRNA and Clinical/Hemodynamic Characteristics Provide Additional Predictive Information About Acute Pulmonary Thromboembolism, Chronic Thromboembolic Pulmonary Hypertension and Idiopathic Pulmonary Hypertension

Frontiers in Pharmacology, 2021
Idiopathic pulmonary artery hypertension (IPAH), chronic thromboembolic pulmonary hypertension (CTEPH), and acute pulmonary embolism (APTE) are life-threatening cardiopulmonary diseases without specific surgical or medical treatment. Although APTE, CTEPH
Alexandre Todorovic Fabro, Alexandre Todorovic Fabro, Juliana Machado-Rugolo, Juliana Machado-Rugolo, Camila Machado Baldavira, Tabatha Gutierrez Prieto, Cecília Farhat, Flavia Regina Rotea ManGone, Sabrina Setembre Batah, Heloísa Resende Cruvinel, Maiara Almeida Aldá, Jhonatas Sirino Monteiro, Adriana Inacio Pádua, Sirlei Siani Morais, Rogério Antônio de Oliveira, Marcel Koenigkam Santos, José Antônio Baddini-Martinez, João Carlos Setubal, Claudia Aparecida Rainho, Hugo Hyung Bok Yoo, Pedro Leme Silva, Pedro Leme Silva, Maria Aparecida Nagai, Maria Aparecida Nagai, Vera Luiza Capelozzi   +24 more
doaj   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

FEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang, Jing Wang, De‐Hui Qian, Yang‐Fan Lv, Tian‐Le Cheng, Da‐Peng Wang, Jing Zhang, Ye Fan   +7 more
wiley   +1 more source

Mechanical forces alter endothelin-1 signaling: comparative ovine models of congenital heart disease

Pulmonary Circulation, 2020
The risk and progression of pulmonary vascular disease in patients with congenital heart disease is dependent on the hemodynamics associated with different lesions. However, the underlying mechanisms are not understood.
Terry Zhu, Samuel Chiacchia, Rebecca J. Kameny, Antoni Garcia De Herreros, Wenhui Gong, Gary W. Raff, Jason B. Boehme, Emin Maltepe, Juan C. Lasheras, Stephen M. Black, Sanjeev A. Datar, Jeffrey R. Fineman   +11 more
doaj   +1 more source

Mechanisms of endothelial cell dysfunction in cystic fibrosis [PDF]

, 2017
Although cystic fibrosis (CF) patients exhibit signs of endothelial perturbation, the functions of the cystic fibrosis conductance regulator (CFTR) in vascular endothelial cells (EC) are poorly defined.
Anile, Marco, Cianci, Eleonora, Del Porto, Paola, Dell'Elba, Giuseppe, Di Silvestre, Sara, Evangelista, Virgilio, Guarnieri, Simone, Lanuti, Paola, Marchisio, Marco, Mari, Veronica C., Mariggiã², Maria A., Moretti, Paolo, Mucilli, Felice, Pandolfi, Assunta, Patruno, Sara, Piccoli, Antonio, Plebani, Roberto, Prioletta, Marco, Recchiuti, Antonio, Romano, Mario, Sacchetti, Silvio, Totani, Licia, Venuta, Federico   +22 more
core   +1 more source

Special delivery: Engineered endothelial cells for pulmonary arterial hypertension [PDF]

Respirology, 2019
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openaire   +3 more sources