Results 81 to 90 of about 183,516 (347)

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, EarlyView.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source

Identification of Prostaglandin I2 Synthase Rare Variants in Patients With Williams Syndrome and Severe Peripheral Pulmonary Stenosis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background Peripheral pulmonary stenosis (PPS) is a condition characterized by the narrowing of the pulmonary arteries, which impairs blood flow to the lung. The mechanisms underlying PPS pathogenesis remain unclear.
Ayako Chida‐Nagai, Hiroyuki Akagawa, Saori Sawai, Yue‐Jiao Ma, Satoshi Yakuwa, Jun Muneuchi, Kazushi Yasuda, Hirokuni Yamazawa, Toshiyuki Yamamoto, Emi Takakuwa, Utano Tomaru, Yoshiyuki Furutani, Tatsuya Kato, Gen Harada, Kei Inai, Toshio Nakanishi, Atsushi Manabe, Atsuhito Takeda, Zhi‐Cheng Jing   +18 more
doaj   +1 more source

Chemerin Added to Endothelin-1 Promotes Rat Pulmonary Artery Smooth Muscle Cell Proliferation and Migration

Frontiers in Physiology, 2020
BackgroundWhile chemerin has been shown to increase proliferation and migration of systemic vascular smooth muscle cells (SMCs) contributing therefore to the development of hypertension, this remains to be clarified for the pulmonary circulation ...
Aliénor Hanthazi, Pascale Jespers, Grégory Vegh, Christine Dubois, Géraldine Hubesch, Jean-Yves Springael, Laurence Dewachter, Kathleen Mc Entee   +7 more
doaj   +1 more source

The role of endothelin-1 in pulmonary arterial hypertension. [PDF]

, 2014
Pulmonary arterial hypertension (PAH) is a rare but debilitating disease, which if left untreated rapidly progresses to right ventricular failure and eventually death. In the quest to understand the pathogenesis of this disease differences in the profile,
Chester, AH, Yacoub, MH
core   +1 more source

Smart Catheters for Diagnosis, Monitoring, and Therapy

Advanced Healthcare Materials, EarlyView.
This study presents a comprehensive review of smart catheters, an emerging class of medical devices that integrate embedded sensors, robotics, and communication systems, offering increased functionality and complexity to enable real‐time health monitoring, diagnostics, and treatment. Abstract This review explores smart catheters as an emerging class of
Azra Yaprak Tarman, Samiha Ahmed, Majed Othman Althumayri, Megan Guy, Darlenne Chavez Lugo, Frances S. Ligler, George T. Ligler, Rahmi Oklu, Hiroshi Kawahira, Michael J. McShane, Jun Kameoka, Jonathan Bova, Hatice Ceylan Koydemir   +12 more
wiley   +1 more source

MicroRNAs in pulmonary arterial remodeling [PDF]

, 2013
Pulmonary arterial remodeling is a presently irreversible pathologic hallmark of pulmonary arterial hypertension (PAH). This complex disease involves pathogenic dysregulation of all cell types within the small pulmonary arteries contributing to vascular ...
A Courboulin, A Eulalio, A Ishisaki, A Jelaska, A Kos, A Sacconi, A Tanzer, A Zampetaki, A Zampetaki, AE Frost, AJ Tijsen, AM Walker, Andrew H. Baker, AR Kuhn, AS Flynt, AY Rangrez, AY Yu, B Wojciak-Stothard, BD Adams, BN Davis, BN Davis-Dusenbery, C Atkinson, C Li, C Sweeney, CA Klattenhoff, CD Cool, CL Bockmeyer, D Cifuentes, D Loffler, DB Badesch, DF Liao, DM Patrick, DP Bartel, E Hergenreider, E Mathe, E Rooij Van, ED Michelakis, FE Wang, G Lagna, G Meister, G Simonneau, G Song, GK Owens, H Beppu, H Kang, H Takahashi, H Tazawa, H Valadi, HY Chiang, J Brennecke, J Kim, J Liu, J Niu, J Ryan, J Sarkar, J Skog, J-S Yang, JD Arroyo, Jennifer S. Grant, JH Newman, JM Boucher, JR Thomson, K Abe, K Rakesh, K Wang, KA O’Donnell, KB Lane, KD Taganov, Kevin White, KN Cowan, KR Cordes, KR Stenmark, KR Stenmark, L Elia, L Guo, L He, L He, L Long, L Tu, LA Brennan, LR Frumkin, M Afrakhte, M Brock, M Das, M Deo, M Humbert, M Humbert, M Humbert, M Izikki, M Rabinovitch, M Trabucchi, M Xin, Margaret R. MacLean, MC Chan, MC Chan, MD Moen, MJ Goumans, MM Hoeper, N Liu, N Raver-Shapira, N Volk, NW Morrell, O Platoshyn, P Caruso, P Fasanaro, P Sklepkiewicz, R Kulshreshtha, R Kumarswamy, R Paulin, RD Machado, RJ Dekker, RM O’Connell, S Bonnet, S Chakravarthy, S Jalali, S Mizuno, S Sakamoto, S Sakao, S Yang, SA Moschos, SS Pullamsetti, T Boettger, T Thum, TC Chang, TX Lu, U Bruning, VN Parikh, W Shi, WB Li, X Huang, X Ji, X Long, X Yang, Y Cheng, Y Cheng, Y Ling, Y Liu, YL Jiang   +137 more
core   +2 more sources

Protein Targets of Monocrotaline Pyrrole in Pulmonary Artery Endothelial Cells [PDF]

Journal of Biological Chemistry, 2000
A single administration of monocrotaline to rats results in pathologic alterations in the lung and heart similar to human pulmonary hypertension. In order to produce these lesions, monocrotaline is oxidized to monocrotaline pyrrole in the liver followed by hematogenous transport to the lung where it injures pulmonary endothelium.
M W, Lamé, A D, Jones, D W, Wilson, S K, Dunston, H J, Segall   +4 more
openaire   +2 more sources

Human Brain Vasculature‐on‐a‐Chip Model Constructed With Microvessels Isolated From Cryopreserved Postmortem Human Brain Tissue

Advanced Healthcare Materials, EarlyView.
This manuscript describes the cultivation of viable microvessels from cryopreserved human brain tissue. When embedded in hydrogels and cultured in microfluidic devices, these microvessels exhibit complex architectures reminiscent of arterioles and capillaries, can be perfused, and display intact barrier function. Collectively, these results demonstrate
Brian J. O'Grady, A. Scott McCall, Samuel Cullison, Daniel Chavarria, Matthew S. Schrag, Ethan S. Lippmann   +5 more
wiley   +1 more source

Vascular smooth muscle contraction in hypertension [PDF]

, 2018
Hypertension is a major risk factor for many common chronic diseases, such as heart failure, myocardial infarction, stroke, vascular dementia and chronic kidney disease.
Alves-Lopes, Rheure, Anagnostopoulou, Aikaterini, Arner, Anders, De Lucca Camargo, Livia, Montezano, Augusto C., Rios, Francisco J., Touyz, Rhian M.   +6 more
core   +1 more source

Progenitor Endothelial Cells in Pulmonary Arterial Hypertension

Journal of General Practice, 2018
Pulmonary artery hypertension (PAH) is common cardio-pulmonary phenomenon associated with higher risk of premature death and disability. Several previous studies have shown that decreased number of circulating endothelial progenitor cells (EPCs) correlated well with vascular remodeling and impaired pulmonary artery function. Moreover, a deep deficiency
openaire   +1 more source