Results 81 to 90 of about 211,135 (314)

Utilising artificial intelligence to determine patients at risk of a rare disease : idiopathic pulmonary arterial hypertension [PDF]

, 2019
Idiopathic pulmonary arterial hypertension is a rare and life-shortening condition often diagnosed at an advanced stage. Despite increased awareness, the delay to diagnosis remains unchanged.
Schmitt, C., Salvatelli, V., Bergemann, R., Flora A. Daniels, Samyshkin, Y., Schmitt, Claude, Doyle, O., Edmund Drage, Claude Schmitt, Doyle, Orla, Orla Doyle, Kiely, David G, Drage, E., Daniels, F.A., Rigg, John, Bergemann, Rito, David G. Kiely, John Rigg, Rigg, J., Salvatelli, Valentina, Daniels, Flora A, Valentina Salvatelli, Drage, Edmund, Harvey Jenner, Yevgeniy Samyshkin, Samyshkin, Yevgeniy, Kiely, D.G., Jenner, Harvey, Lawrie, A., Rito Bergemann, Allan Lawrie, Lawrie, Allan, Jenner, H.   +32 more
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Super‐Resolution Ultrasound Based Cell Tracking With Polymeric Nanobubbles

Advanced Materials, EarlyView.
This study presents a super‐resolution ultrasound platform for tracking cells in vivo. Biocompatible polymeric nanobubbles are used as highly echogenic intracellular labels. Following the injection of cells and microbubbles, ultrasound localization microscopy (ULM) can dynamically match the microvascular architecture and individual cell trajectories ...
Junlin Chen, Xiaoyu Wang, Jilin Fan, Bi Wang, Hanghang Fang, Yurui Wang, Hao Cui, Mohammad Roufarshbaf, Ekaterina Savina, Alexandra Valeske, Quim Peña, Yang Shi, Andreas Herrmann, Twan Lammers, Mathias Hornef, Roman Barmin, Thomas Lisson, Georg Schmitz, Anne Rix, Fabian Kiessling   +19 more
wiley   +1 more source

Effects of pirbuterol and sodium nitroprusside on pulmonary haemodynamics in hypoxic cor pulmonale

, 1983
The acute haemodynamic effects of oral pirbuterol (a beta-agonist) were contrasted with those of sodium nitroprusside, a vasodilator, in six patients with hypoxic chronic bronchitis and emphysema.
Wathen, C G, Macnee, William, Flenley, DC, Hannan, W J, Muir, A.L   +4 more
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RhoA activation by hypoxia in pulmonary arterial smooth muscle cells is age and site specific

, 2004
Hypoxia induces vasoconstriction of pulmonary arteries through contraction of smooth muscle cells (SMCs). The GTPase RhoA regulates smooth muscle contractility and actin cytoskeletal remodeling through the Rho-associated kinase ( ROCK).
Bailly, K, Ridley, A J, Haworth, SG, Ridley, AJ, Hall, SM, Hall, S M, Haworth, S G   +6 more
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Magnetic Micro‐ and Nanorobots for Precision Thrombolysis: Design Strategies and Translational Challenges

Advanced Robotics Research, EarlyView.
Micro‐ and nanorobots for targeted thrombolysis. This perspective elaborates on the clinical indication of blood clot disorders and current limitations for treatment. As a novel, alternative solution, micro‐ and nanorobots can be used to treat and break down thrombi.
Joshua M. Mesfin, Yimo Yan, Nikola Cesarovic, Simone Schuerle   +3 more
wiley   +1 more source

CircPMS1 promotes proliferation of pulmonary artery smooth muscle cells, pulmonary microvascular endothelial cells, and pericytes under hypoxia

Animal Models and Experimental Medicine
Background Circular RNAs (circRNAs) have been recognized as significant regulators of pulmonary hypertension (PH); however, the differential expression and function of circRNAs in different vascular cells under hypoxia remain unknown. Here, we identified
Xiaoyi Hu, Shang Wang, Hui Zhao, Yaqin Wei, Ruowang Duan, Rong Jiang, Wenhui Wu, Qinhua Zhao, Sugang Gong, Lan Wang, Jinming Liu, Ping Yuan   +11 more
doaj   +1 more source

Increased Levels of Runt-Related Transcription Factor 2 Are Associated With Poor Survival of Patients With Idiopathic Pulmonary Arterial Hypertension

American Journal of Men's Health, 2020
Runt-related transcription factor 2 (RUNX2) plays a pivotal role in the pathogenesis of pulmonary arterial hypertension (PAH); yet, whether circulating levels of RUNX2 can predict survival of patients with idiopathic PAH (IPAH) is still unclear.
Xuntao Yuan MD, Zuogang Wang MD, Lan Wang MD, Qinhua Zhao MD, Sugang Gong MD, Yuanyuan Sun MD, Qian Liu MD, Ping Yuan MD   +7 more
doaj   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

Improvements in Hemodynamics and Right Heart Remodeling Following Balloon Pulmonary Angioplasty Treatment in Patients With Chronic Thromboembolic Pulmonary Hypertension: A Retrospective Study

Health Science Reports
Background and Aims This study aimed to evaluate the hemodynamic alterations and right heart remodeling dynamics in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) undergoing treatment with balloon pulmonary angioplasty ...
Qi‐Le Shen, Qin‐Hua Zhao, Hui‐Ting Li, Jie Deng, Jing He, Lan Wang, Su‐Gang Gong, Jin‐Ming Liu   +7 more
doaj   +1 more source

Classical supravalvar aortic stenosis and peripheral pulmonary stenosis [PDF]

, 2014
Supravalvar aortic stenosis as well as peripheral pulmonary stenosis are rare forms of congenital heart disease, which occur, however, relatively frequently in association.
Ramakrishnan, S., Gupta, S.K., Kahr, P.C., Kothari, Shyam S.   +3 more
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