Results 71 to 80 of about 117,017 (302)

Expression of SARS‐CoV‐2 entry‐associated proteins in COPD airways: an immunohistochemical study

The Journal of Pathology, EarlyView.
Abstract Coronavirus disease 2019 (COVID‐19) is of special concern to patients with chronic obstructive pulmonary disease (COPD), given their susceptibility to exacerbations caused by respiratory tract infections. As the susceptibility of acquiring a SARS‐CoV‐2 infection in COPD remains unclear, this study explored the airway expression of SARS‐CoV‐2 ...
Larissa E Vlaming‐van Eijk, Zarlasht Sarsam, Janna Bakker, Marjan Reinders‐Luinge, Corry‐Anke Brandsma, Wim Timens   +5 more
wiley   +1 more source

Cardiovascular Function in Pulmonary Emphysema [PDF]

BioMed Research International, 2013
Chronic obstructive pulmonary disease (COPD) and chronic cardiovascular disease, such as coronary artery disease, congestive heart failure, and cardiac arrhythmias, have a strong influence on each other, and systemic inflammation has been considered as the main linkage between them.
VISCA, Dina, AIELLO, Marina, CHETTA, Alfredo Antonio   +2 more
openaire   +4 more sources

Age‐Dependent Correlation of Pulmonary Function Impairment and Aortic Arch Stiffness in Mice

Pediatric Discovery, EarlyView.
This study examined the relationship between aortic arch stiffness and lung function in aging mice. Multiple linear regression modeling showed moderate to strong correlations between the rise in aortic arch stiffness and changes in lung function as the mice progressively aged.
Ayman Isbatan, Samuel M. Lee, Ali Imran Sarwar, Yuxing Yuan, Sunny Chen, Maricela Castellon, Dan A. Marian, Richard D. Minshall, Jie Tian, Irena Levitan, Jiwang Chen   +10 more
wiley   +1 more source

Eosinophils promote pulmonary matrix destruction and emphysema via Cathepsin L

Signal Transduction and Targeted Therapy, 2023
Patients with chronic obstructive pulmonary disease (COPD) who exhibit elevated blood eosinophil levels often experience worsened lung function and more severe emphysema.
Xia Xu, Tao Yu, Lingling Dong, Rainer Glauben, Siyuan Wu, Ronghua Huang, Shiwei Qumu, Chenli Chang, Jing Guo, Lin Pan, Ting Yang, Xin Lin, Ke Huang, Zhihua Chen, Chen Wang   +14 more
doaj   +1 more source

Clinical Significance of Bronchodilator Responsiveness Evaluated by Forced Vital Capacity in COPD: SPIROMICS Cohort Analysis. [PDF]

, 2019
ObjectiveBronchodilator responsiveness (BDR) is prevalent in COPD, but its clinical implications remain unclear. We explored the significance of BDR, defined by post-bronchodilator change in FEV1 (BDRFEV1) as a measure reflecting the change in flow and ...
Anderson, Wayne, Arjomandi, Mehrdad, Barjaktarevic, Igor Z, Bhakta, Nirav R, Bhatt, Surya P, Bowler, Russell, Buhr, Russell G, Christenson, Stephanie A, Cooper, Christopher B, Couper, David, Criner, Gerard, Curtis, Jeffrey L, Doerschuk, Claire M, Dransfield, Mark T, Drummond, M Bradley, Han, MeiLan K, Hansel, Nadia, Hoffman, Eric A, Hu, Scott, Kaner, Robert J, Kanner, Richard E, Kim, Victor, Krishnan, Jerry A, Martinez, Fernando J, NHLBI SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), O'Neal, Wanda K, Ortega, Victor E, Paine Iii, Robert, Peters, Stephen P, Pirozzi, Cheryl S, Ronish, Bonnie, Tashkin, Donald P, Wang, Xiaoyan, Wells, James Michael, Woodruff, Prescott G   +34 more
core   +2 more sources

A Combined Model‐Based Meta‐Analysis of Aggregated and Individual FEV1 Data From Randomized COPD Trials

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Model‐based meta‐analysis allows integration of aggregated‐level data (AD) from different clinical trials in one model to assess population efficacy/safety. However, AD is limited in individual‐level information, while individual‐patient‐level data (IPD) are hard to obtain. Combined modeling may take advantage of both sources.
Liang Yang, Carolina Llanos‐Paez, Shuying Yang, Claire Ambery, Alienor Berges, Maria C. Kjellsson, Mats O. Karlsson   +6 more
wiley   +1 more source

Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease [PDF]

, 2016
Background: Cigarette smoke induced oxidative stress has been shown to reduce silent information regulator 1 (Sirt1) levels in lung tissue from smokers and patients with COPD patients.
Akai, Masaya, Iguchi, Masaharu, Ishizaki, Takeshi, Kadowaki, Maiko, Kato, Ryo, Mizuno, Shiro, Nakagawa, Ken, Oikawa, Taku, Osanai, Kazuhiro, Shiozaki, Kohei, Toga, Hirohisa, Voelkel, Norbert F   +11 more
core   +2 more sources

Identification of Clinically Distinct Clusters in Patients With Severe COPD Using Circulating Blood Cell Population Parameters

Respirology, EarlyView.
This study investigated whether blood cell population data, in addition to cell counts, can identify clinically relevant COPD subgroups. Four distinct inflammatory profiles were identified with distinct clinical characteristics. Cell population data have the potential to provide additional insights beyond inflammatory cell counts and improve patient ...
Pauline J. M. Kuks, Jorine E. Hartman, Else A. M. D. ter Haar, L. Joost van Pelt, Dirk‐Jan Slebos, Maarten van den Berge, Simon D. Pouwels   +6 more
wiley   +1 more source

Deletion of vitamin D receptor leads to premature emphysema/COPD by increased matrix metalloproteinases and lymphoid aggregates formation [PDF]

, 2011
Deficiency of vitamin D is associated with accelerated decline in lung function. Vitamin D is a ligand for nuclear hormone vitamin D receptor (VDR), and upon binding it modulates various cellular functions.
Hwang, Jae-woong, Rahman, Irfan, Sun, Jun, Sundar, Isaac K, Wu, Shaoping   +4 more
core   +1 more source

Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development

Small, EarlyView.
Extracellular vesicles (EVs) hold promise for chronic obstructive pulmonary disease (COPD) treatment but face challenges with storage and delivery. This study demonstrates the stabilization of lung fibroblast‐derived EVs using inulin, enabling freeze‐drying and spray‐drying.
Eva M. Jansen, Luke van der Koog, Robin A.B. Elferink, Karim Rafie, Anika Nagelkerke, Reinoud Gosens, Henderik W. Frijlink, Wouter L.J. Hinrichs   +7 more
wiley   +1 more source