Results 81 to 90 of about 1,195,100 (331)

Epigenetic Dysregulation of the NKX2‐1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease

Respirology, EarlyView.
This study investigated airway epithelial barrier dysfunction persistence in ex‐smokers with COPD and underlying mechanisms using single‐cell RNA and ATAC sequencing. Epigenetic NKX2‐1/SPDEF dysregulation maintains goblet cell hyperplasia and barrier dysfunction despite long‐term smoking cessation.
Ayaka Shiota, Keiko Kan‐o, Yumiko Ishii, Tomoaki Koga, Takeshi Sawada, Kei‐ichiro Yasunaga, Shingo Usuki, Tatsuya Katsuno, Shigesato Inoue, Tomohiro Ogawa, Akihiro Jo, Satoru Fukuyama, Mitsuyoshi Nakao, Hiroaki Ogata, Mizuho A. Kido, Sachiko Tsukita, Koichiro Matsumoto, Isamu Okamoto   +17 more
wiley   +1 more source

Quantitative severity of pulmonary emphysema as a prognostic factor for recurrence in patients with surgically resected non‐small cell lung cancer

Thoracic Cancer, 2019
Background Pulmonary emphysema is a major component of chronic obstructive pulmonary disease and lung cancer. However the prognostic significance of quantitative emphysema severity in patients with lung cancer is unclear.
Seung Jun Lee, Jung Wan Yoo, Sunmi Ju, Yu Ji Cho, Jong Duk Kim, Sung Hwan Kim, In‐Seok Jang, Bae Kwon Jeong, Gyeong‐Won Lee, Yi Yeong Jeong, Ho Cheol Kim, Kyungsoo Bae, Kyung Nyeo Jeon, Jong Deog Lee   +13 more
doaj   +1 more source

Stabilized Extracellular Vesicle Formulations for Inhalable Dry Powder Development

Small, EarlyView.
Extracellular vesicles (EVs) hold promise for chronic obstructive pulmonary disease (COPD) treatment but face challenges with storage and delivery. This study demonstrates the stabilization of lung fibroblast‐derived EVs using inulin, enabling freeze‐drying and spray‐drying.
Eva M. Jansen, Luke van der Koog, Robin A.B. Elferink, Karim Rafie, Anika Nagelkerke, Reinoud Gosens, Henderik W. Frijlink, Wouter L.J. Hinrichs   +7 more
wiley   +1 more source

T3 Intratracheal Therapy Alleviates Pulmonary Pathology in an Elastase-Induced Emphysema-Dominant COPD Mouse Model [PDF]

, 2023
N. Takahashi, Ryunosuke Nakashima, Aoi Nasu, Megumi Hayashi, Haruka Fujikawa, Taisei Kawakami, Yuka Eto, Tomoki Kishimoto, Ayami Fukuyama, Choyo Ogasawara, Keisuke Kawano, Yukio Fujiwara, Mary Ann Suico, Hirofumi Kai, Tsuyoshi Shuto   +14 more
openalex   +1 more source

Clinical characteristics of immediate allergic adverse reactions to intravenous amoxicillin‒clavulanic acid in conscious dogs

Veterinary Record, EarlyView.
Abstract Background Amoxicillin‒clavulanic acid (AMC) is one of the most frequently used antibiotics in small animal practice, and reports on adverse reactions are scarce. The aim of this study was to describe the clinical characteristics of immediate allergic adverse reactions to intravenous (IV) AMC in conscious dogs. Methods The medical records of a
Leonel Frutuoso, Anna Threlfall
wiley   +1 more source

Phase I clinical trial of cell therapy in patients with advanced chronic obstructive pulmonary disease: follow-up of up to 3 years

Revista Brasileira de Hematologia e Hemoterapia, 2013
BACKGROUND Chronic obstructive pulmonary disease is a major inflammatory disease of the airways and an enormous therapeutic challenge. Within the spectrum of chronic obstructive pulmonary disease, pulmonary emphysema is characterized by the destruction ...
Talita Stessuk, Milton Artur Ruiz, Oswaldo Tadeu Greco, Aldemir Bilaqui, Maria Jose de Oliveira Ribeiro-Paes, Joao Tadeu Ribeiro-Paes   +5 more
doaj   +1 more source

Electronic health records improve the diagnosis and prognosis of pulmonary fungal infections in lung cancer patients

VIEW, EarlyView.
Pulmonary fungal infections are life‐threatening complications in lung cancer patients, posing significant challenges in clinical management. To address this, we developed machine learning tools that translate routine electronic health record data into actionable insights for diagnosing infections and assessing prognosis.
Hongwei Meng, Jiayun Yang, Shouzhi Yang, Ayizekeranmu Yiming, Wenjun Yu, Yuewei Zhao, Chunmeng Ding, Kexin Meng, Si Gao, Yang Li, Nan Dan, Dandan Feng, Yunhua Xu, Lin Huang, Yongxia Qiao   +14 more
wiley   +1 more source

Acute exacerbations of chronic obstructive pulmonary disease in a cohort of Chinese never smokers goes along with decreased risks of recurrent acute exacerbation, emphysema and comorbidity of lung cancer as well as decreased levels of circulating eosinophils and basophils [PDF]

, 2022
Guangdong Wang, Aiping Ma, Liang Zhang, Jiaxi Guo, Qun Liu, Frank Petersen, Zhanxiang Wang, Xinhua Yu   +7 more
openalex   +1 more source

Transforming acute exacerbations of chronic obstructive pulmonary disease (AECOPD) risk assessment: A multi‐algorithm machine learning approach for precise clinical phenotyping

VIEW, EarlyView.
We addressed the clinical need for individualized early identification of AECOPD by analyzing a longitudinal cohort of 878 COPD patients (20072024) and benchmarking 91 algorithms, yielding an interpretable ensemble model (AECOPD‐RS). The model showed strong performance (C‐index 0.815; validation 1/3/5‐year AUCs 0.864/0.865/0.855), with SHAP/VIMP ...
Yiqun Dong, Junyi Shen, Chaofan Fan, Anqi Lin, Peng Luo, Xin Chen   +5 more
wiley   +1 more source

Pulmonary Edema and Emphysema in Cattle After Intraruminal and Intravenous Administration of 3-Methylindole [PDF]

, 1975
James R. Carlson, Earl O. Dickinson, M. T. Yokoyama, Bruce Bradley   +3 more
openalex   +1 more source